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UFS busy with exciting research into flavours and fragrances

11 July 2022 | Story Andre Damons | Photo Supplied

Prof Martie Smith and Prof Drik Opperman — Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

Flavours and fragrances have a wide application in the food, feed, cosmetic, chemical and pharmaceutical sectors. Many flavour compounds are still produced via chemical synthesis or via extraction from plant or animal sources. However, there is increasing interest in their bio-production or the use of flavour compounds of (micro) biological origin.

One reason for this shift is that chemical synthesis often uses environmentally unfriendly processes. Chemical synthesis usually also produces racemic mixtures with the second enantiomer, mirror image of the looked-for compound, often having undesirable organoleptic properties. Furthermore, the consumer has developed a “chemophobia”-attitude towards synthetic chemical compounds, especially when related to food and home-care products. This applies even to nature-identical compounds – products that occur in nature but are produced via a non-natural chemical process. Products produced with the use of enzymes or microbes from “natural” substrates can be labelled “natural”. The flavour and fragrance industry thus pay higher prices for such products labelled as “natural”.

The invention

A University of the Free State (UFS) team, led by Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry are conducting exciting research in this area. They filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

The invention relates to a process for the enzymatic in-chain hydroxylation of C12 to C16 fatty acids, alcohols, and alkanes. Hydroxylation of C12 fatty acid and alcohol provides routes for the synthesis of “natural” δ-dodecalactone. The advantage of these routes is that they do not rely on massoia lactones. Massoia lactones are derived from the bark of Massoia trees which grow in Indonesia. Harvesting of the bark kills the trees.

The cytochrome P450 enzymes (P450s) claimed in this patent are to the inventors’ knowledge the most regioselective enzymes described thus far that can be used for the synthesis of δ-dodecalactone from lauric acid or 1-dodecanol. The approach that the technology takes is to claim cytochrome P450 enzymes that share 70 % amino acid identity to a set of selected P450s for the regioselective hydroxylation of lauric acid and 1-dodecanol to synthesise δ-dodecalactone.

Still in early stage

The current state of development is early stage with the technology only demonstrated in the laboratory on a small scale (100-200 ml). Before the technology can be commercialised the team would need to further improve the regioselectivity and stability of the P450s and proof that the reactions can be scaled up in bioreactors. The technology will probably be delivered as an enzyme (amino acid sequence) with the desired properties.

There are other research groups working on a synthetic biology approach for the de novo synthesis of δ-dodecalactone from glucose by genetically engineered microbes. It is still unclear how such a process will compare in terms of product yields, economics and environmental impact with the processes proposed by the UFS patent.

If the team had to partner with a commercial company, their first choice would be to work with an established flavour and fragrance company. Another possibility would be the small French flavour and fragrance company that Dr Alizé Pennec, the post-doc and co-inventor who initially discovered the unique P450 activity, is working for.

Please view the videos for more information on patents.

The Vice-Rector: Research and Internationalisation has released two new calls for applications for funding. Academic staff and researchers are encouraged to submit applications for these funds. At this stage we are not accepting projects from Research Fellows.

The two funds are:

1. The Industrial Engagement Fund

2. The Intellectual Property Commercialisation Fund

Each fund has its own guidelines and application process. The guidelines are attached. The applications must be filled in on RIMS.

The RIMS application forms can be found through this link

For more information please click the documents below:

IP Commercialisation Fund Concept Note

The UFS Industry Engagement Fund Concept Note

News Archive

UFS committed to a two-language model

2010-08-13

Prof. Jonathan Jansen

The University of the Free State (UFS) will continue to use a two-language model while it builds capacity for research and teaching in Sotho languages.

This was announced by the Rector and Vice-Chancellor of the UFS, Prof. Jonathan Jansen, when he delivered the 29th DF Malherbe Memorial Lecture on the Main Campus in Bloemfontein yesterday, on the topic: The politics and prospects of Afrikaans, and Afrikaans schools and universities.

“In the course of time black students will learn Afrikaans, white students will learn Sesotho, and all students will learn decent English,” he said.

“Classes will remain in English and Afrikaans, especially in the first years of study. Dual-medium classrooms will break down the racial isolation where outstanding university teachers are comfortable in both languages. Parallel-medium classes will exist where large numbers enable such a facility.”

He said schools and higher education institutions that continue to use language as an instrument of exclusion, rather than inclusion, would remain “culturally and linguistically impoverished”. He said the future of Afrikaans in these institutions lay in its inter-dependence and co-existence with other languages.

“A strong two-language model of education, whether in the form of double- or parallel-medium instruction within a racially integrated campus environment is the only way in which Afrikaans can and should flourish in a democratic South Africa,” he said.

“It is the only model that resolves two problems at the same time: the demand for racial equity, on the one hand, and the demand for language recognition, on the other hand.”

He said the idea of an exclusively Afrikaans university was a “dangerous” one.

“It will lock up white students in a largely uni-racial and uni-lingual environment, given that the participation rates in higher education for Afrikaans-speaking black students are and for a long time will remain very low,” he said.

“This will be a disaster for many Afrikaans-speaking students for it will mean that the closed circles of social, cultural and linguistic socialization will remain uninterrupted from family to school to university.

“Rather than prepare students for a global world marked by language flexibility and cultural diversity, students will remain locked into a sheltered racial environment at the very stage where most South African students first experience the liberation of the intellect and the broadening of opportunities for engaging with the world around them.

“The choice at the Afrikaans universities, therefore, must never be a choice between Afrikaans and English; it must be both.”

Download lecture

Media Release
Issued by: Lacea Loader
Director: Strategic Communication (actg)
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl@ufs.ac.za
13 August 2010

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