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11 July 2022 | Story Andre Damons | Photo Supplied
Prof Martie Smith and Prof Drik Opperman
Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

Flavours and fragrances have a wide application in the food, feed, cosmetic, chemical and pharmaceutical sectors. Many flavour compounds are still produced via chemical synthesis or via extraction from plant or animal sources. However, there is increasing interest in their bio-production or the use of flavour compounds of (micro) biological origin. 

One reason for this shift is that chemical synthesis often uses environmentally unfriendly processes. Chemical synthesis usually also produces racemic mixtures with the second enantiomer, mirror image of the looked-for compound, often having undesirable organoleptic properties. Furthermore, the consumer has developed a “chemophobia”-attitude towards synthetic chemical compounds, especially when related to food and home-care products.  This applies even to nature-identical compounds – products that occur in nature but are produced via a non-natural chemical process. Products produced with the use of enzymes or microbes from “natural” substrates can be labelled “natural”. The flavour and fragrance industry thus pay higher prices for such products labelled as “natural”.  

The invention

A University of the Free State (UFS) team, led by Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry are conducting exciting research in this area. They filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.  

The invention relates to a process for the enzymatic in-chain hydroxylation of C12 to C16 fatty acids, alcohols, and alkanes. Hydroxylation of C12 fatty acid and alcohol provides routes for the synthesis of “natural” δ-dodecalactone. The advantage of these routes is that they do not rely on massoia lactones. Massoia lactones are derived from the bark of Massoia trees which grow in Indonesia. Harvesting of the bark kills the trees.  

The cytochrome P450 enzymes (P450s) claimed in this patent are to the inventors’ knowledge the most regioselective enzymes described thus far that can be used for the synthesis of δ-dodecalactone from lauric acid or 1-dodecanol. The approach that the technology takes is to claim cytochrome P450 enzymes that share 70 % amino acid identity to a set of selected P450s for the regioselective hydroxylation of lauric acid and 1-dodecanol to synthesise δ-dodecalactone.

Still in early stage

The current state of development is early stage with the technology only demonstrated in the laboratory on a small scale (100-200 ml). Before the technology can be commercialised the team would need to further improve the regioselectivity and stability of the P450s and proof that the reactions can be scaled up in bioreactors. The technology will probably be delivered as an enzyme (amino acid sequence) with the desired properties. 

There are other research groups working on a synthetic biology approach for the de novo synthesis of δ-dodecalactone from glucose by genetically engineered microbes. It is still unclear how such a process will compare in terms of product yields, economics and environmental impact with the processes proposed by the UFS patent.

If the team had to partner with a commercial company, their first choice would be to work with an established flavour and fragrance company. Another possibility would be the small French flavour and fragrance company that Dr Alizé Pennec, the post-doc and co-inventor who initially discovered the unique P450 activity, is working for.

Please view the videos for more information on patents.

The Vice-Rector: Research and Internationalisation has released two new calls for applications for funding. Academic staff and researchers are encouraged to submit applications for these funds. At this stage we are not accepting projects from Research Fellows. 

The two funds are: 

1.  The Industrial Engagement Fund 
2.  The Intellectual Property Commercialisation Fund

Each fund has its own guidelines and application process. The guidelines are attached. The applications must be filled in on RIMS.

The RIMS application forms can be found through this link

For more information please click the documents below:



News Archive

Unique programme for next generation of professors launched
2010-11-19

Some of the scholars taking part in the Vice-Chancellor's Prestige Young Scholars Programme are, from the left: Dr Andréhette Verster, Ms Liezel Kotzé and Dr Nthabeleng Rammile.
Photo: Stephen Collett

The University of the Free State (UFS) has launched a programme that will provide an accelerated pathway to 25 young scholars with recent PhDs and teach them how to become professors through intensive local and international mentorship, research support and academic training.

The Vice-Chancellor’s Prestige Programme for Young Scholars focuses on the next generation of top researchers in South Africa who will fill the gap left by retiring academics. It will also add significantly to the diversity of the professoriate at the UFS.

No other university in the country has a programme of such scale and intensity for building excellence and diversity through young scholars.

“The programme is highly selective and limited to the most promising young scholars at the university. It will also contribute towards establishing an international reputation for the university and positioning the UFS as one of the best research institutions in the country,” said Prof. Neil Roos, Director of the Postgraduate School at the UFS. He will manage the programme together with Prof. Jackie du Toit, also from the university.

Running for the next three years, the programme will put the 25 scholars through an intensive programme of academic and scholarship support which includes advanced theoretical and methodological training and exposure to leading international scholars in their fields. They will also be exposed to intensive reading and writing programmes, high-level seminar and conference participation and presentation, accelerated publication schedules and personal mentoring and advising plans.

“Scholarship will only grow if there is a critical mass – and this is what we want to achieve at the UFS. We want to create a pool of young scholars, develop and connect them with international scholars and place them at top universities in the world where they can be mentored by the best in their respective fields,” said Prof. Jonathan Jansen, Vice-Chancellor and Rector of the UFS at the launch of the programme.

According to Prof. Jansen, the UFS aims to draw public intellectuals and A-rated scientists to the campus and make academic work attractive to academics at the university and countrywide.

The group of scholars has a good academic record, with 69% of them completing their PhDs within the last five years. The group is well represented in terms of race and gender; the majority are in the 26 to 30-year age group and specialisations include the social sciences (including education, the humanities and arts) as well as the natural sciences.

“Scholarship develops over time. We are proud and extremely honoured to be selected for this prestigious programme. With this scholarship we acknowledge the responsibility of building the UFS and of extending our knowledge across disciplines. We will establish a scholarly advancement for our university that will enable it to compete with the best in the world,” said Dr Nalize Marais, one of the prestige scholars.

The launch was also attended by members of the university’s International Advisory Council (IAC). This council, which visited the university the past week to advise the leadership on its future positioning strategies, especially in relation to its international aspiration to become a place of scholarship and service among the leading universities in the world, congratulated the UFS on this groundbreaking programme.

“You are lucky to have a leadership that dares to dream and that can act the dream. You are fortunate that your leadership wants to take this university forward and explore new horizons,” said Prof. Aki Saweyrr, former Secretary-General of the Association of African Universities in Ghana and member of the IAC.

Ending the evening’s programme was Dr Gansen Pillay, Vice-President of the National Research Foundation. Prof. Gansen also congratulated the UFS on its visionary and inspirational leadership. “It is a privilege to make a life-changing contribution to research in the world. Universities must take ownership of their own development – which is exactly what the UFS is doing. And, although this is a truly South African programme, it could have an impact on the rest of the world,” he said.
 

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