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11 July 2022 | Story Andre Damons | Photo Supplied
Prof Martie Smith and Prof Drik Opperman
Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

Flavours and fragrances have a wide application in the food, feed, cosmetic, chemical and pharmaceutical sectors. Many flavour compounds are still produced via chemical synthesis or via extraction from plant or animal sources. However, there is increasing interest in their bio-production or the use of flavour compounds of (micro) biological origin. 

One reason for this shift is that chemical synthesis often uses environmentally unfriendly processes. Chemical synthesis usually also produces racemic mixtures with the second enantiomer, mirror image of the looked-for compound, often having undesirable organoleptic properties. Furthermore, the consumer has developed a “chemophobia”-attitude towards synthetic chemical compounds, especially when related to food and home-care products.  This applies even to nature-identical compounds – products that occur in nature but are produced via a non-natural chemical process. Products produced with the use of enzymes or microbes from “natural” substrates can be labelled “natural”. The flavour and fragrance industry thus pay higher prices for such products labelled as “natural”.  

The invention

A University of the Free State (UFS) team, led by Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry are conducting exciting research in this area. They filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.  

The invention relates to a process for the enzymatic in-chain hydroxylation of C12 to C16 fatty acids, alcohols, and alkanes. Hydroxylation of C12 fatty acid and alcohol provides routes for the synthesis of “natural” δ-dodecalactone. The advantage of these routes is that they do not rely on massoia lactones. Massoia lactones are derived from the bark of Massoia trees which grow in Indonesia. Harvesting of the bark kills the trees.  

The cytochrome P450 enzymes (P450s) claimed in this patent are to the inventors’ knowledge the most regioselective enzymes described thus far that can be used for the synthesis of δ-dodecalactone from lauric acid or 1-dodecanol. The approach that the technology takes is to claim cytochrome P450 enzymes that share 70 % amino acid identity to a set of selected P450s for the regioselective hydroxylation of lauric acid and 1-dodecanol to synthesise δ-dodecalactone.

Still in early stage

The current state of development is early stage with the technology only demonstrated in the laboratory on a small scale (100-200 ml). Before the technology can be commercialised the team would need to further improve the regioselectivity and stability of the P450s and proof that the reactions can be scaled up in bioreactors. The technology will probably be delivered as an enzyme (amino acid sequence) with the desired properties. 

There are other research groups working on a synthetic biology approach for the de novo synthesis of δ-dodecalactone from glucose by genetically engineered microbes. It is still unclear how such a process will compare in terms of product yields, economics and environmental impact with the processes proposed by the UFS patent.

If the team had to partner with a commercial company, their first choice would be to work with an established flavour and fragrance company. Another possibility would be the small French flavour and fragrance company that Dr Alizé Pennec, the post-doc and co-inventor who initially discovered the unique P450 activity, is working for.

Please view the videos for more information on patents.

The Vice-Rector: Research and Internationalisation has released two new calls for applications for funding. Academic staff and researchers are encouraged to submit applications for these funds. At this stage we are not accepting projects from Research Fellows. 

The two funds are: 

1.  The Industrial Engagement Fund 
2.  The Intellectual Property Commercialisation Fund

Each fund has its own guidelines and application process. The guidelines are attached. The applications must be filled in on RIMS.

The RIMS application forms can be found through this link

For more information please click the documents below:



News Archive

UFS academic delivers inaugural lecture on challenges confronting political science in the 21st century
2012-10-12

Prof. Hussein Solomon.
Photo: Stephen Collett
12 October 2012

This week Prof. Hussein Solomon, Senior Professor in the Department of Political Studies and Governance delivered his inaugural lecture on the Bloemfontein Campus of the University of the Free State (UFS).

In his lecture, “Challenges confronting political science in the 21st century, A South African perspective”, Prof. Solomon explored five challenges to academic political science in general and to South African political scientists in particular.

The challenges include the need to localise international relations theory with an emphasis on the emancipatory dimensions; exploring the nexus between technology and politics; incorporating political anthropology into mainstream political science syllabi; rising to the challenge of governing Africa’s cities; and the dangers of over-specialisation in an era that demands the use of a broader academic lens.

According to Prof. Solomon, political science has come a long way from those heady days in 1950 when Lasswell could confidently state that politics was about who gets what, when and how.

“Indeed, the world of 2012 scarcely resembles the world of 1950. Immanuel Wallerstein was correct in his assessment that the modern world system is coming to an end. As political scientists, we need to interrogate our existing knowledge constructs in relation to this rapidly changing reality. We need to indigenise international relations theory and emphasise creating an emancipatory and counter-hegemonic discourse.

We need to explore the nexus between technology and politics to deepen our democracy by empowering the margins in our societies. We need to embrace political anthropology as we strive to understand non-Western forms of governance. We need to use these understandings of traditional societies as we create hybrid forms of urban governance that stress inclusivity as we overcome the politics of identity and difference. We need to heed the call of De Tocqueville and create a new political science to understand the new times by supplementing disciplinary insights with those from other disciplines. In doing so, political science will once more regain its relevance to humanity in the twenty-first century,” Prof. Solomon said.
 

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