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11 July 2022 | Story Andre Damons | Photo Supplied
Prof Martie Smith and Prof Drik Opperman
Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

Flavours and fragrances have a wide application in the food, feed, cosmetic, chemical and pharmaceutical sectors. Many flavour compounds are still produced via chemical synthesis or via extraction from plant or animal sources. However, there is increasing interest in their bio-production or the use of flavour compounds of (micro) biological origin. 

One reason for this shift is that chemical synthesis often uses environmentally unfriendly processes. Chemical synthesis usually also produces racemic mixtures with the second enantiomer, mirror image of the looked-for compound, often having undesirable organoleptic properties. Furthermore, the consumer has developed a “chemophobia”-attitude towards synthetic chemical compounds, especially when related to food and home-care products.  This applies even to nature-identical compounds – products that occur in nature but are produced via a non-natural chemical process. Products produced with the use of enzymes or microbes from “natural” substrates can be labelled “natural”. The flavour and fragrance industry thus pay higher prices for such products labelled as “natural”.  

The invention

A University of the Free State (UFS) team, led by Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry are conducting exciting research in this area. They filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.  

The invention relates to a process for the enzymatic in-chain hydroxylation of C12 to C16 fatty acids, alcohols, and alkanes. Hydroxylation of C12 fatty acid and alcohol provides routes for the synthesis of “natural” δ-dodecalactone. The advantage of these routes is that they do not rely on massoia lactones. Massoia lactones are derived from the bark of Massoia trees which grow in Indonesia. Harvesting of the bark kills the trees.  

The cytochrome P450 enzymes (P450s) claimed in this patent are to the inventors’ knowledge the most regioselective enzymes described thus far that can be used for the synthesis of δ-dodecalactone from lauric acid or 1-dodecanol. The approach that the technology takes is to claim cytochrome P450 enzymes that share 70 % amino acid identity to a set of selected P450s for the regioselective hydroxylation of lauric acid and 1-dodecanol to synthesise δ-dodecalactone.

Still in early stage

The current state of development is early stage with the technology only demonstrated in the laboratory on a small scale (100-200 ml). Before the technology can be commercialised the team would need to further improve the regioselectivity and stability of the P450s and proof that the reactions can be scaled up in bioreactors. The technology will probably be delivered as an enzyme (amino acid sequence) with the desired properties. 

There are other research groups working on a synthetic biology approach for the de novo synthesis of δ-dodecalactone from glucose by genetically engineered microbes. It is still unclear how such a process will compare in terms of product yields, economics and environmental impact with the processes proposed by the UFS patent.

If the team had to partner with a commercial company, their first choice would be to work with an established flavour and fragrance company. Another possibility would be the small French flavour and fragrance company that Dr Alizé Pennec, the post-doc and co-inventor who initially discovered the unique P450 activity, is working for.

Please view the videos for more information on patents.

The Vice-Rector: Research and Internationalisation has released two new calls for applications for funding. Academic staff and researchers are encouraged to submit applications for these funds. At this stage we are not accepting projects from Research Fellows. 

The two funds are: 

1.  The Industrial Engagement Fund 
2.  The Intellectual Property Commercialisation Fund

Each fund has its own guidelines and application process. The guidelines are attached. The applications must be filled in on RIMS.

The RIMS application forms can be found through this link

For more information please click the documents below:



News Archive

Prof. André Keet appointed to Ministerial Oversight Committee on Higher Education
2013-01-15

 

Prof. André Keet
Photo: Anja Aucamp
24 January 2013



Prof. André Keet, Director of the Institute for Reconciliation and Social Justice at the university, has been appointed as member of the Oversight Committee on the Transformation of South African Universities. He is one of seven committee members that were appointed by the Ministry of Higher Education and Training to monitor progress on transformation in public universities.

The committee will advise Dr Blade Nzimande, Minister of Higher Education and Training, on policy to combat racism, sexism and other forms of unfair discrimination in public higher education. The committee will also advise on the role of universities in promoting the development of a free, fair and non-discriminatory society beyond the world of the academia.

The senior leadership of the university has welcomed the appointment of Prof. Keet and said with his extensive experience as a former Commissioner on the Commission for Gender Equality and as the Director of the university's Institute for Reconciliation and Social Justice (which was formed as one of several initiatives taken by the senior leadership in the aftermath of the Reitz incident), Prof. Keet will be a valuable member of the committee.

"Prof. Keet has the experience and expertise to guard the autonomy and academic freedom of universities, thus avoiding this committee from becoming a political intervention in the affairs of the higher education sector," said Prof. Jonathan Jansen, Vice-Chancellor and Rector of the university.

Honoured to be elected on the committee, Prof. Keet said he is ready to serve the national interest in the transformation of South African universities. "The appointment is also a compliment to the university and to its exceptional experience in the process of transformation."

Prof. Keet will serve on the committee for a period of three years. The other members of the committee are Prof. Malegapuru Makgoba, who will serve as chairperson, Dr Mvuyo Tom, Ms Nazeema Mohamed, Ms Zingiswa Losi, Mr Joe Mpisi and Prof. Shirley Walters.

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