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UFS busy with exciting research into flavours and fragrances

11 July 2022 | Story Andre Damons | Photo Supplied

Prof Martie Smith and Prof Drik Opperman — Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

Flavours and fragrances have a wide application in the food, feed, cosmetic, chemical and pharmaceutical sectors. Many flavour compounds are still produced via chemical synthesis or via extraction from plant or animal sources. However, there is increasing interest in their bio-production or the use of flavour compounds of (micro) biological origin.

One reason for this shift is that chemical synthesis often uses environmentally unfriendly processes. Chemical synthesis usually also produces racemic mixtures with the second enantiomer, mirror image of the looked-for compound, often having undesirable organoleptic properties. Furthermore, the consumer has developed a “chemophobia”-attitude towards synthetic chemical compounds, especially when related to food and home-care products. This applies even to nature-identical compounds – products that occur in nature but are produced via a non-natural chemical process. Products produced with the use of enzymes or microbes from “natural” substrates can be labelled “natural”. The flavour and fragrance industry thus pay higher prices for such products labelled as “natural”.

The invention

A University of the Free State (UFS) team, led by Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry are conducting exciting research in this area. They filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

The invention relates to a process for the enzymatic in-chain hydroxylation of C12 to C16 fatty acids, alcohols, and alkanes. Hydroxylation of C12 fatty acid and alcohol provides routes for the synthesis of “natural” δ-dodecalactone. The advantage of these routes is that they do not rely on massoia lactones. Massoia lactones are derived from the bark of Massoia trees which grow in Indonesia. Harvesting of the bark kills the trees.

The cytochrome P450 enzymes (P450s) claimed in this patent are to the inventors’ knowledge the most regioselective enzymes described thus far that can be used for the synthesis of δ-dodecalactone from lauric acid or 1-dodecanol. The approach that the technology takes is to claim cytochrome P450 enzymes that share 70 % amino acid identity to a set of selected P450s for the regioselective hydroxylation of lauric acid and 1-dodecanol to synthesise δ-dodecalactone.

Still in early stage

The current state of development is early stage with the technology only demonstrated in the laboratory on a small scale (100-200 ml). Before the technology can be commercialised the team would need to further improve the regioselectivity and stability of the P450s and proof that the reactions can be scaled up in bioreactors. The technology will probably be delivered as an enzyme (amino acid sequence) with the desired properties.

There are other research groups working on a synthetic biology approach for the de novo synthesis of δ-dodecalactone from glucose by genetically engineered microbes. It is still unclear how such a process will compare in terms of product yields, economics and environmental impact with the processes proposed by the UFS patent.

If the team had to partner with a commercial company, their first choice would be to work with an established flavour and fragrance company. Another possibility would be the small French flavour and fragrance company that Dr Alizé Pennec, the post-doc and co-inventor who initially discovered the unique P450 activity, is working for.

Please view the videos for more information on patents.

The Vice-Rector: Research and Internationalisation has released two new calls for applications for funding. Academic staff and researchers are encouraged to submit applications for these funds. At this stage we are not accepting projects from Research Fellows.

The two funds are:

1. The Industrial Engagement Fund

2. The Intellectual Property Commercialisation Fund

Each fund has its own guidelines and application process. The guidelines are attached. The applications must be filled in on RIMS.

The RIMS application forms can be found through this link

For more information please click the documents below:

IP Commercialisation Fund Concept Note

The UFS Industry Engagement Fund Concept Note

News Archive

Lots of inspiration at Autumn Graduation Ceremony

2013-04-18

Graduates celebrate the results of years of study at the graduation ceremony on the Bloemfontein Campus.
Photo: Hannes Pieterse
17 April 2013

Live streaming of ceremonies available from 16 April - 19 April 2013: http://www.ufs.ac.za/ufslivestreaming/

Joshua Johnson YouTube video

The university’s Autumn Graduation Ceremony got off to a vibrant start with energetic performances and inspiring messages for graduates.

Joshua Johnson, an American student who uses his talent for tap-dancing to fund his tertiary education, mesmerised the audience on the first of the four-day graduation ceremony with his story of hope and perseverance. The student from Penn State University travels five hours by bus to New York every weekend where he tap-dances on the subway trains to earn money for his tuition fees.

Delivering a keynote address, Joshua told graduates that, in order to achieve their goals, they have to understand and work diligently with the 24 hours they get to live daily. “Start with a bang and end with a bang,” he said, encouraging the audience in the nearly-packed Callie Human Centre to join him in a rhythmic tap-dancing beat.

“Don’t follow in the footsteps of someone else. Take the beat of life, but add your rhythm to it," his wise words resonating with the exhilarated graduates.

Joshua will be the guest speaker at the ceremonies on 16, 17 and 19 April 2013 and will deliver a dance item during each occasion.

Dr Khotso Mokhele, Chancellor of the University, echoed Joshua‘s message, telling graduates not to be discouraged by life’s difficulties.

“Take what you have learned over the last three or four years and use that knowledge to reach your goal,” he advised.

Prof Jonathan Jansen, Rector and Vice-Chancellor, encouraged them to continue to study. “To break the cycle of poverty, get an education, get a degree.” He told them that as graduates they are ten times more likely to get a job, with the odds rising as they continue their postgraduate studies.

Well-known radio host and Idols South Africa judge, Gareth Cliff, will be the guest speaker at two ceremonies on 18 April 2013. He will be joined by Vicus Visser, the South African YouTube singing sensation. Dubbed Bloemfontein’s Justin Bieber, Vicus and his brother Vincent will perform during these two ceremonies.

The programme for the respective ceremonies is:

Wednesday 17 April

09:30 Diplomas and certificates up to and including honours degrees in the Faculty of Education.
14:30 Diplomas and certificates up to and including honours degrees in the Faculties of Health Sciences, Law and Theology.

Thursday 18 April

09:30 Diplomas and certificates up to and including honours degrees in the Faculty of Natural and Agricultural Sciences: only Agricultural Sciences and Architecture.
14:30 Diplomas and certificates up to and including honours degrees in the Faculty of Natural and Agricultural Sciences: only Natural Sciences.

Friday 19 April

09:30 Diplomas and certificates up to and including honours degrees in the Faculty of Economic and Management Sciences: all diplomas and degrees in the Faculty, except BCom and BComHons.
14:30 Diplomas and certificates up to and including honours degrees in the Faculty of Economic and Management Sciences: only BCom and BComHons.

The Qwaqwa Campus’ graduation ceremony will take place on 8 June 2013. Diplomas/certificates up to and including doctorates will be awarded at this ceremony.

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