Latest News Archive

Please select Category, Year, and then Month to display items

UFS busy with exciting research into flavours and fragrances

11 July 2022 | Story Andre Damons | Photo Supplied

Prof Martie Smith and Prof Drik Opperman — Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

Flavours and fragrances have a wide application in the food, feed, cosmetic, chemical and pharmaceutical sectors. Many flavour compounds are still produced via chemical synthesis or via extraction from plant or animal sources. However, there is increasing interest in their bio-production or the use of flavour compounds of (micro) biological origin.

One reason for this shift is that chemical synthesis often uses environmentally unfriendly processes. Chemical synthesis usually also produces racemic mixtures with the second enantiomer, mirror image of the looked-for compound, often having undesirable organoleptic properties. Furthermore, the consumer has developed a “chemophobia”-attitude towards synthetic chemical compounds, especially when related to food and home-care products. This applies even to nature-identical compounds – products that occur in nature but are produced via a non-natural chemical process. Products produced with the use of enzymes or microbes from “natural” substrates can be labelled “natural”. The flavour and fragrance industry thus pay higher prices for such products labelled as “natural”.

The invention

A University of the Free State (UFS) team, led by Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry are conducting exciting research in this area. They filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

The invention relates to a process for the enzymatic in-chain hydroxylation of C12 to C16 fatty acids, alcohols, and alkanes. Hydroxylation of C12 fatty acid and alcohol provides routes for the synthesis of “natural” δ-dodecalactone. The advantage of these routes is that they do not rely on massoia lactones. Massoia lactones are derived from the bark of Massoia trees which grow in Indonesia. Harvesting of the bark kills the trees.

The cytochrome P450 enzymes (P450s) claimed in this patent are to the inventors’ knowledge the most regioselective enzymes described thus far that can be used for the synthesis of δ-dodecalactone from lauric acid or 1-dodecanol. The approach that the technology takes is to claim cytochrome P450 enzymes that share 70 % amino acid identity to a set of selected P450s for the regioselective hydroxylation of lauric acid and 1-dodecanol to synthesise δ-dodecalactone.

Still in early stage

The current state of development is early stage with the technology only demonstrated in the laboratory on a small scale (100-200 ml). Before the technology can be commercialised the team would need to further improve the regioselectivity and stability of the P450s and proof that the reactions can be scaled up in bioreactors. The technology will probably be delivered as an enzyme (amino acid sequence) with the desired properties.

There are other research groups working on a synthetic biology approach for the de novo synthesis of δ-dodecalactone from glucose by genetically engineered microbes. It is still unclear how such a process will compare in terms of product yields, economics and environmental impact with the processes proposed by the UFS patent.

If the team had to partner with a commercial company, their first choice would be to work with an established flavour and fragrance company. Another possibility would be the small French flavour and fragrance company that Dr Alizé Pennec, the post-doc and co-inventor who initially discovered the unique P450 activity, is working for.

Please view the videos for more information on patents.

The Vice-Rector: Research and Internationalisation has released two new calls for applications for funding. Academic staff and researchers are encouraged to submit applications for these funds. At this stage we are not accepting projects from Research Fellows.

The two funds are:

1. The Industrial Engagement Fund

2. The Intellectual Property Commercialisation Fund

Each fund has its own guidelines and application process. The guidelines are attached. The applications must be filled in on RIMS.

The RIMS application forms can be found through this link

For more information please click the documents below:

IP Commercialisation Fund Concept Note

The UFS Industry Engagement Fund Concept Note

News Archive

Study Abroad Fair presents exciting opportunities

2013-04-23

Staff and students gain a wealth of information at the first Study Abroad Fair hosted on the Bloemfontein Campus.
Photo: Stephen Collett
23 April 2013

Kovsie staff and students gained a wealth of information at the first Study Abroad Fair hosted by the Office for International Affairs on the Bloemfontein Campus.

Representatives from partner universities across the USA, Europe and Asia took part in the fair, giving information on study opportunities abroad. They were joined by representatives of international funding agencies and foreign missions from countries including Canada, Indonesia, France and the Republic of Azerbaijan, who gave information on funding opportunities to study overseas.

Welcoming visitors, Ms Dineo Gaofhiwe-Ingram, Assistant Director: Internationalisation, said international education forms a very important and critical part of the university’s strategy of aiming and working towards becoming a research intensive university.

“I believe all here understand and know the value of an international education, both as a donor agency, as an embassy that has bilateral agreements with the South African government to support education, and as a staff member that is here with students to encourage them to go abroad. It is important that our staff and students get to learn and experience from others and others from them.”

Dr Choice Makhetha, Vice-Rector: External Relations, encouraged Kovsies “to visit the world and bring the world back to the UFS.”

Prof Jonathan Jansen, Vice-Chancellor and Rector, had a similar message, talking about the advantages of seeing the world. “You never get to be a good leader unless your sense of the world is bigger than yourself. My goal is to make sure that almost every undergraduate student has some experience of studying abroad.“

List of Exhibitors who took part in the Study Abroad Fair:

1. Funding Agencies
Embassy of USA
Embassy of France
Embassy of The Republic of Azerbaijan
European Union
Embassy of Canada
National Research Foundation (NRF)
Embassy of Switzerland
Embassy of Indonesia
Czech Republic Embassy
Research Africa
British Council

2. Partner Universities Abroad
Mahasarakham University (Thailand)
Appalachian State University (USA)
University of Brussels
Radboud University Nijmegen
The Hague University of Applied Sciences
University of Bremen
VU University Amsterdam
University of Groningen
University of Antwerp
University of Leuven
Jönköping University

3. UFS Representation
Postgraduate School (UFS)
Office for International Affairs (UFS)
Faculty of Education (UFS)
Department of Plant Sciences (UFS)
Department of Social Work (UFS)

Back

Economic and Management Sciences

Education

Health Sciences

The Humanities

Law

Natural and Agricultural Sciences

Theology and Religion

Open Distance Learning

Business School

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept