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UFS busy with exciting research into flavours and fragrances

11 July 2022 | Story Andre Damons | Photo Supplied

Prof Martie Smith and Prof Drik Opperman — Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

Flavours and fragrances have a wide application in the food, feed, cosmetic, chemical and pharmaceutical sectors. Many flavour compounds are still produced via chemical synthesis or via extraction from plant or animal sources. However, there is increasing interest in their bio-production or the use of flavour compounds of (micro) biological origin.

One reason for this shift is that chemical synthesis often uses environmentally unfriendly processes. Chemical synthesis usually also produces racemic mixtures with the second enantiomer, mirror image of the looked-for compound, often having undesirable organoleptic properties. Furthermore, the consumer has developed a “chemophobia”-attitude towards synthetic chemical compounds, especially when related to food and home-care products. This applies even to nature-identical compounds – products that occur in nature but are produced via a non-natural chemical process. Products produced with the use of enzymes or microbes from “natural” substrates can be labelled “natural”. The flavour and fragrance industry thus pay higher prices for such products labelled as “natural”.

The invention

A University of the Free State (UFS) team, led by Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry are conducting exciting research in this area. They filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

The invention relates to a process for the enzymatic in-chain hydroxylation of C12 to C16 fatty acids, alcohols, and alkanes. Hydroxylation of C12 fatty acid and alcohol provides routes for the synthesis of “natural” δ-dodecalactone. The advantage of these routes is that they do not rely on massoia lactones. Massoia lactones are derived from the bark of Massoia trees which grow in Indonesia. Harvesting of the bark kills the trees.

The cytochrome P450 enzymes (P450s) claimed in this patent are to the inventors’ knowledge the most regioselective enzymes described thus far that can be used for the synthesis of δ-dodecalactone from lauric acid or 1-dodecanol. The approach that the technology takes is to claim cytochrome P450 enzymes that share 70 % amino acid identity to a set of selected P450s for the regioselective hydroxylation of lauric acid and 1-dodecanol to synthesise δ-dodecalactone.

Still in early stage

The current state of development is early stage with the technology only demonstrated in the laboratory on a small scale (100-200 ml). Before the technology can be commercialised the team would need to further improve the regioselectivity and stability of the P450s and proof that the reactions can be scaled up in bioreactors. The technology will probably be delivered as an enzyme (amino acid sequence) with the desired properties.

There are other research groups working on a synthetic biology approach for the de novo synthesis of δ-dodecalactone from glucose by genetically engineered microbes. It is still unclear how such a process will compare in terms of product yields, economics and environmental impact with the processes proposed by the UFS patent.

If the team had to partner with a commercial company, their first choice would be to work with an established flavour and fragrance company. Another possibility would be the small French flavour and fragrance company that Dr Alizé Pennec, the post-doc and co-inventor who initially discovered the unique P450 activity, is working for.

Please view the videos for more information on patents.

The Vice-Rector: Research and Internationalisation has released two new calls for applications for funding. Academic staff and researchers are encouraged to submit applications for these funds. At this stage we are not accepting projects from Research Fellows.

The two funds are:

1. The Industrial Engagement Fund

2. The Intellectual Property Commercialisation Fund

Each fund has its own guidelines and application process. The guidelines are attached. The applications must be filled in on RIMS.

The RIMS application forms can be found through this link

For more information please click the documents below:

IP Commercialisation Fund Concept Note

The UFS Industry Engagement Fund Concept Note

News Archive

It’s Rag Time!

2014-01-14

Zakes Bantwini, Mango Groove and Robbie Wessels
Photos: Supplied

Kovsie Rag Community Service will start 2014 off with the well-known Rag festivities, with enthusiastic students already starting with float building in January. The theme for Rag CS 2014 is ‘Movies.’

As from 20 January, a cheerful atmosphere will be present at the Kovsie Rag farm, with senior and junior students working hard, while social cohesion is developing between them. Great entertainment will be part of these festivities, with the likes of DJ Euphonik and Adam performing on 31 January.
In the midst of all these activities, the annual ‘Chicken Run’ evening collections will take place on 21, 23 and 28 January, as well as the Ritsim sales in Bloemfontein and surrounding areas on 24-25 January.

The hard work will reach its peak with the judging of the floats on the morning of 1 February, after which the floats will depart at 09:00 for the first procession of the day. This route will end at Twin City Mall at 11:00, where 10 000 meals will be distributed to communities in Heidedal and Mangaung. Learners from Heidedal schools will entertain the public with their talents.

Our very popular family festival will already start at 16:00 with the opening of the gates at Chevrolet Park Cricket Stadium. Young and old will be entertained by well-known and vibrant artists, such as Robbie Wessels, Mango Groove, Zakes Bantwini, as well as a spectacular firework show. Come early to ensure a great spot on the grass.

The float winners will be announced at 17:00, whereafter the main procession of the day will depart from the Tempe robot in Nelson Mandela Drive at 18:00. The public can look forward to this ever popular procession through the streets of Bloemfontein, with decorated floats and students cradling collection tins proceeding to Chevrolet Park. The 2012/2013 UFS Rag queen, Mr Rag and their retinue will greet the public from the main float. Finalists for the 2013/2014 UFS Rag queen and Mr Rag titles, as well as drum majorettes, will also accompany the procession.

Do not miss out on this wonderful family festival – come early, bring your family and picnic blanket/chairs to ensure a great spot on the grass – a variety of refreshments will be on sale.

Tickets available from Computicket and entrance gates.

Tickets: R60 per person
R30 per child under 12

We would also like to make use of this opportunity to remind you of our vibrant 2013/2014 UFS Rag coronation ball, where the UFS Rag queen and Mr Rag CS for 2014 will be crowned on 14 February 2014 in the Callie Human Centre, UFS Campus.

Limited tickets will be available at R500 per couple and can be bought from the Rag Community Service office from 5 February 2014.

Enquiries:

Karen Scheepers +27(0)51 401 2423 ( ScheepersK@ufs.ac.za )
Esmé Wessels +27(0)51 401 3769 ( Wesselse@ufs.ac.za )

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