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UFS busy with exciting research into flavours and fragrances

11 July 2022 | Story Andre Damons | Photo Supplied

Prof Martie Smith and Prof Drik Opperman — Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

Flavours and fragrances have a wide application in the food, feed, cosmetic, chemical and pharmaceutical sectors. Many flavour compounds are still produced via chemical synthesis or via extraction from plant or animal sources. However, there is increasing interest in their bio-production or the use of flavour compounds of (micro) biological origin.

One reason for this shift is that chemical synthesis often uses environmentally unfriendly processes. Chemical synthesis usually also produces racemic mixtures with the second enantiomer, mirror image of the looked-for compound, often having undesirable organoleptic properties. Furthermore, the consumer has developed a “chemophobia”-attitude towards synthetic chemical compounds, especially when related to food and home-care products. This applies even to nature-identical compounds – products that occur in nature but are produced via a non-natural chemical process. Products produced with the use of enzymes or microbes from “natural” substrates can be labelled “natural”. The flavour and fragrance industry thus pay higher prices for such products labelled as “natural”.

The invention

A University of the Free State (UFS) team, led by Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry are conducting exciting research in this area. They filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

The invention relates to a process for the enzymatic in-chain hydroxylation of C12 to C16 fatty acids, alcohols, and alkanes. Hydroxylation of C12 fatty acid and alcohol provides routes for the synthesis of “natural” δ-dodecalactone. The advantage of these routes is that they do not rely on massoia lactones. Massoia lactones are derived from the bark of Massoia trees which grow in Indonesia. Harvesting of the bark kills the trees.

The cytochrome P450 enzymes (P450s) claimed in this patent are to the inventors’ knowledge the most regioselective enzymes described thus far that can be used for the synthesis of δ-dodecalactone from lauric acid or 1-dodecanol. The approach that the technology takes is to claim cytochrome P450 enzymes that share 70 % amino acid identity to a set of selected P450s for the regioselective hydroxylation of lauric acid and 1-dodecanol to synthesise δ-dodecalactone.

Still in early stage

The current state of development is early stage with the technology only demonstrated in the laboratory on a small scale (100-200 ml). Before the technology can be commercialised the team would need to further improve the regioselectivity and stability of the P450s and proof that the reactions can be scaled up in bioreactors. The technology will probably be delivered as an enzyme (amino acid sequence) with the desired properties.

There are other research groups working on a synthetic biology approach for the de novo synthesis of δ-dodecalactone from glucose by genetically engineered microbes. It is still unclear how such a process will compare in terms of product yields, economics and environmental impact with the processes proposed by the UFS patent.

If the team had to partner with a commercial company, their first choice would be to work with an established flavour and fragrance company. Another possibility would be the small French flavour and fragrance company that Dr Alizé Pennec, the post-doc and co-inventor who initially discovered the unique P450 activity, is working for.

Please view the videos for more information on patents.

The Vice-Rector: Research and Internationalisation has released two new calls for applications for funding. Academic staff and researchers are encouraged to submit applications for these funds. At this stage we are not accepting projects from Research Fellows.

The two funds are:

1. The Industrial Engagement Fund

2. The Intellectual Property Commercialisation Fund

Each fund has its own guidelines and application process. The guidelines are attached. The applications must be filled in on RIMS.

The RIMS application forms can be found through this link

For more information please click the documents below:

IP Commercialisation Fund Concept Note

The UFS Industry Engagement Fund Concept Note

News Archive

UFS academic discusses Dutch, Afrikaans and African languages

2006-05-22

During the colloquium presented in Belgium by the Province Antwerp were from the left Prof Pol Cuvelier (University of Antwerp), Prof Theo du Plessis (Director: Unit for Language Management at the UFS), Mr Ludo Helsen (Permanent Deputy: Province of Antwerp) and Mr Jean-Pierre Rondas (Flemish radio journalist).

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UFS academic discusses Dutch, Afrikaans and African languages at international conference

Prof Theo du Plessis, Director of the Unit for Language Management at the University of the Free State (UFS), was the main speaker at a colloquium titled “Routes: Where to now? - Een traject van het Nederlands naar het Afrikaans en de Afrikatalen”, which was recently presented by the Province Antwerp in Belgium.

The aim of the colloquium was to discuss the future cooperation in the field of language between the Province Antwerp and South Africa.

The Province Antwerp is already involved with projects in South Africa. One of these projects is the Multilingual Information Development Programme (MIDP), a partnership project between the UFS and the Free State Province that is mainly funded by the Province Antwerp.

The project has been running since 1999 and was recently in the news with the presentation of a symposium on multilingualism and exclusion on the Main Campus of the UFS. It is hoped that the Routes colloquium will indicate new stages on which can be added to the already successful cooperation in the area of language.

Prof Du Plessis’s presentation titled “Nederlands, Afrikaans en die Afrikatale – kan samewerking slaag? Die geval MIDP in die Vrystaat”, investigated the successes that have been made with the MIDP. He discussed two possible approaches to cooperation in the areas of language, that of a sentimentalistic approach against an instrumentalistic approach.

Cooperation in the first approach makes language the aim. In the second approach language is used as a means to a greater aim. According to Prof du Plessis the first approach is driven by a romantisised idea about the relation between the Flemish and Afrikaans speaking people, which may unfortunately polarise the position of Afrikaans in South Africa even further.

He argues that, given the time that we are in, the second approach will deliver more constructive results as language can among others be used for to further democracy in South Africa. This can happen by cooperation in the institutionalising of multilingualism in our society. The more languages are used in education, law and government administration, the more we can be assured a successful democracy.

The Routes colloquium was facilitated by the well-known Flemish radio journalist, Jean-Pierre Rondas. About twenty South African and Flemish language specialists took part in the colloquium. Dr Fritz Kok, outgoing chief executive officer of the ATKV took part in the opening ceremony and Dr Neville Alexander from the University of Cape Town and well-known activist for multilingualism in South Africa was also one of the main speakers.

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