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UFS busy with exciting research into flavours and fragrances

11 July 2022 | Story Andre Damons | Photo Supplied

Prof Martie Smith and Prof Drik Opperman — Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

Flavours and fragrances have a wide application in the food, feed, cosmetic, chemical and pharmaceutical sectors. Many flavour compounds are still produced via chemical synthesis or via extraction from plant or animal sources. However, there is increasing interest in their bio-production or the use of flavour compounds of (micro) biological origin.

One reason for this shift is that chemical synthesis often uses environmentally unfriendly processes. Chemical synthesis usually also produces racemic mixtures with the second enantiomer, mirror image of the looked-for compound, often having undesirable organoleptic properties. Furthermore, the consumer has developed a “chemophobia”-attitude towards synthetic chemical compounds, especially when related to food and home-care products. This applies even to nature-identical compounds – products that occur in nature but are produced via a non-natural chemical process. Products produced with the use of enzymes or microbes from “natural” substrates can be labelled “natural”. The flavour and fragrance industry thus pay higher prices for such products labelled as “natural”.

The invention

A University of the Free State (UFS) team, led by Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry are conducting exciting research in this area. They filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

The invention relates to a process for the enzymatic in-chain hydroxylation of C12 to C16 fatty acids, alcohols, and alkanes. Hydroxylation of C12 fatty acid and alcohol provides routes for the synthesis of “natural” δ-dodecalactone. The advantage of these routes is that they do not rely on massoia lactones. Massoia lactones are derived from the bark of Massoia trees which grow in Indonesia. Harvesting of the bark kills the trees.

The cytochrome P450 enzymes (P450s) claimed in this patent are to the inventors’ knowledge the most regioselective enzymes described thus far that can be used for the synthesis of δ-dodecalactone from lauric acid or 1-dodecanol. The approach that the technology takes is to claim cytochrome P450 enzymes that share 70 % amino acid identity to a set of selected P450s for the regioselective hydroxylation of lauric acid and 1-dodecanol to synthesise δ-dodecalactone.

Still in early stage

The current state of development is early stage with the technology only demonstrated in the laboratory on a small scale (100-200 ml). Before the technology can be commercialised the team would need to further improve the regioselectivity and stability of the P450s and proof that the reactions can be scaled up in bioreactors. The technology will probably be delivered as an enzyme (amino acid sequence) with the desired properties.

There are other research groups working on a synthetic biology approach for the de novo synthesis of δ-dodecalactone from glucose by genetically engineered microbes. It is still unclear how such a process will compare in terms of product yields, economics and environmental impact with the processes proposed by the UFS patent.

If the team had to partner with a commercial company, their first choice would be to work with an established flavour and fragrance company. Another possibility would be the small French flavour and fragrance company that Dr Alizé Pennec, the post-doc and co-inventor who initially discovered the unique P450 activity, is working for.

Please view the videos for more information on patents.

The Vice-Rector: Research and Internationalisation has released two new calls for applications for funding. Academic staff and researchers are encouraged to submit applications for these funds. At this stage we are not accepting projects from Research Fellows.

The two funds are:

1. The Industrial Engagement Fund

2. The Intellectual Property Commercialisation Fund

Each fund has its own guidelines and application process. The guidelines are attached. The applications must be filled in on RIMS.

The RIMS application forms can be found through this link

For more information please click the documents below:

IP Commercialisation Fund Concept Note

The UFS Industry Engagement Fund Concept Note

News Archive

Launch of the Africa office of the IIDE

2006-05-25

Attending the launch of the Africa office of the IIDE were from the left Prof Sytse Strijbos (Chairperson of IIDE Europe), Rev Kiepie Jaftha (Chairperson of the IIDE in Africa’s Board of Directors and Chief Director: Community Service at the UFS) and Prof Frederick Fourie (Rector and Vice-Chancellor of the UFS).

Attending the launch were from the left Prof Lucius Botes (Director: Centre of Development Support at the UFS), Dr Samuel Kareithi (Head: Community Development at the Cornerstone Christian College, Cape Town), Rev Kiepie Jaftha (Chairperson of the IIDE in Africa’s Board of Directors and Chief Director: Community Service at the UFS), Prof Sytse Strijbos (Chairperson of IIDE Europe) and Dr Ezekiel Moraka (Vice-Rector: Student Affairs at the UFS).

Africa office of IIDE launched on UFS main campus

The Africa office of the International Institute for Development and Ethics (IIDE) was today (26 May 2006) launched on the Main Campus of the University of the Free State (UFS) in Bloemfontein.

“The IIDE specialises in the studying and research of general questions of developmental theory and practices and provides services and support in education, strategic planning, policy formulation, advocacy and capacity building of development agencies,” said Rev Kiepie Jaftha, Chairperson of the IIDE in Africa’s Board of Directors and Chief Director: Community Service at the UFS.

According to Rev Jaftha the IIDE in Africa will focus on the conceptual and normative aspects of developmental processes in Sub-Saharan Africa. “We want to foster local and international partnerships with various relevant role-players in civil society, the private sector and public sector in the SACD region and later expand our operations to the rest of Africa,” said Rev Jaftha.

The IIDE in Africa cooperates with a similar foundation in Europe, functioning as the IIDE Europe. This institute was founded in 2003 and its head office is situated in the Netherlands. The UFS is a funder of the IIDE in Africa together with the Paul Foundation and private sponsors from the Netherlands.

“We have already started with various projects which are in various stages of implementation,” said Rev Jaftha. Some of these projects include, among others, the broadening of the master’s degree in Christian Studies of Science and Society (MACSSS) which is currently housed at the Vrije Universiteit in Amsterdam to tertiary institutions in South Africa such as the UFS, the University of Stellenbosch and the Potchefstroom Campus of the Northwest University.

“Another project is an investigation into the possibility of initiating a broad development initiative in the poverty stricken Qwaqwa area. This initiative will attempt to concentrate on issues like the training and empowerment of prospective entrepreneurs in the region, the identification of prospective entrepreneurs for the rendering of development support and the monitoring of the impact of information and communication technology on local communities during the implementation of sustainable development initiatives,” said Rev Jaftha.

“The establishment of the Africa office of the IIDE on the UFS Main Campus is an indication of one of the aims of the UFS to play a role in South Africa and Africa. It also signifies our aim to contribute meaningfully to research and development and to establish links between the academe and practice,” said Rev Jaftha.

Media release
Issued by: Lacea Loader
Media Representative
Tel: (051) 401-2584
Cell: 083 645 2454
E-mail: loaderl.stg@mail.uovs.ac.za
26 May 2006

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