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11 July 2022 | Story Andre Damons | Photo Supplied
Prof Martie Smith and Prof Drik Opperman
Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

Flavours and fragrances have a wide application in the food, feed, cosmetic, chemical and pharmaceutical sectors. Many flavour compounds are still produced via chemical synthesis or via extraction from plant or animal sources. However, there is increasing interest in their bio-production or the use of flavour compounds of (micro) biological origin. 

One reason for this shift is that chemical synthesis often uses environmentally unfriendly processes. Chemical synthesis usually also produces racemic mixtures with the second enantiomer, mirror image of the looked-for compound, often having undesirable organoleptic properties. Furthermore, the consumer has developed a “chemophobia”-attitude towards synthetic chemical compounds, especially when related to food and home-care products.  This applies even to nature-identical compounds – products that occur in nature but are produced via a non-natural chemical process. Products produced with the use of enzymes or microbes from “natural” substrates can be labelled “natural”. The flavour and fragrance industry thus pay higher prices for such products labelled as “natural”.  

The invention

A University of the Free State (UFS) team, led by Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry are conducting exciting research in this area. They filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.  

The invention relates to a process for the enzymatic in-chain hydroxylation of C12 to C16 fatty acids, alcohols, and alkanes. Hydroxylation of C12 fatty acid and alcohol provides routes for the synthesis of “natural” δ-dodecalactone. The advantage of these routes is that they do not rely on massoia lactones. Massoia lactones are derived from the bark of Massoia trees which grow in Indonesia. Harvesting of the bark kills the trees.  

The cytochrome P450 enzymes (P450s) claimed in this patent are to the inventors’ knowledge the most regioselective enzymes described thus far that can be used for the synthesis of δ-dodecalactone from lauric acid or 1-dodecanol. The approach that the technology takes is to claim cytochrome P450 enzymes that share 70 % amino acid identity to a set of selected P450s for the regioselective hydroxylation of lauric acid and 1-dodecanol to synthesise δ-dodecalactone.

Still in early stage

The current state of development is early stage with the technology only demonstrated in the laboratory on a small scale (100-200 ml). Before the technology can be commercialised the team would need to further improve the regioselectivity and stability of the P450s and proof that the reactions can be scaled up in bioreactors. The technology will probably be delivered as an enzyme (amino acid sequence) with the desired properties. 

There are other research groups working on a synthetic biology approach for the de novo synthesis of δ-dodecalactone from glucose by genetically engineered microbes. It is still unclear how such a process will compare in terms of product yields, economics and environmental impact with the processes proposed by the UFS patent.

If the team had to partner with a commercial company, their first choice would be to work with an established flavour and fragrance company. Another possibility would be the small French flavour and fragrance company that Dr Alizé Pennec, the post-doc and co-inventor who initially discovered the unique P450 activity, is working for.

Please view the videos for more information on patents.

The Vice-Rector: Research and Internationalisation has released two new calls for applications for funding. Academic staff and researchers are encouraged to submit applications for these funds. At this stage we are not accepting projects from Research Fellows. 

The two funds are: 

1.  The Industrial Engagement Fund 
2.  The Intellectual Property Commercialisation Fund

Each fund has its own guidelines and application process. The guidelines are attached. The applications must be filled in on RIMS.

The RIMS application forms can be found through this link

For more information please click the documents below:



News Archive

Six of our students on their way to Stanford Sophomore College
2014-08-21


Back, from the left are: Philip Kitsopoulos (BCom Law), Ulrich Kristen (Medicine)
and Stephan Erasmus (Medicine).

The university hosted a send-off function for our students who are about to attend a three-week seminar at Stanford Sophomore College (SoCo).

Six Kovsie students were selected to attend the seminar at the Stanford SoCo in September 2014. This programme is an immersive learning experience where participants attend class meetings during the morning. Their afternoons include class activities, explorations of Stanford, field trips as well as organised events.

UFS students were invited to apply for one of six SoCo courses in February 2014. After months of apprehension, the successful Kovsie applicants were announced in May this year.

These outstanding Kovsie students and the courses they will attend are:

  • Sebabatso Makafane, Vuyisile Kubeka and Philip Kitsopoulos – New Millennium Mix: Crossings of Race and Culture;
  • Ulrich Kristen – Resistance Writings in Nazi Germany;
  • Kaylene Pillay – Ghost Stories: Why the Dead Return and What They Want From Us; and
  • Stephan Erasmus – Responses to the AIDS Epidemic.

During the farewell function, Rudi Buys: Dean of Student Affairs, handed the students their flight tickets and visas. This was followed by messages of support from Dr Lis Lange, Directorate for Institutional Research and Academic Planning, and Prof Neil Roos from the Centre for Africa Studies.

Prof Roos concluded the evening’s programme with some advice for these students. “Don’t go there and come back to copy the students and personalities you meet there. Go there and show your own characteristics to them.”

The six Kovsies will depart on 29 August and return home on 19 September 2014.

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