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UFS busy with exciting research into flavours and fragrances

11 July 2022 | Story Andre Damons | Photo Supplied

Prof Martie Smith and Prof Drik Opperman — Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

Flavours and fragrances have a wide application in the food, feed, cosmetic, chemical and pharmaceutical sectors. Many flavour compounds are still produced via chemical synthesis or via extraction from plant or animal sources. However, there is increasing interest in their bio-production or the use of flavour compounds of (micro) biological origin.

One reason for this shift is that chemical synthesis often uses environmentally unfriendly processes. Chemical synthesis usually also produces racemic mixtures with the second enantiomer, mirror image of the looked-for compound, often having undesirable organoleptic properties. Furthermore, the consumer has developed a “chemophobia”-attitude towards synthetic chemical compounds, especially when related to food and home-care products. This applies even to nature-identical compounds – products that occur in nature but are produced via a non-natural chemical process. Products produced with the use of enzymes or microbes from “natural” substrates can be labelled “natural”. The flavour and fragrance industry thus pay higher prices for such products labelled as “natural”.

The invention

A University of the Free State (UFS) team, led by Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry are conducting exciting research in this area. They filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

The invention relates to a process for the enzymatic in-chain hydroxylation of C12 to C16 fatty acids, alcohols, and alkanes. Hydroxylation of C12 fatty acid and alcohol provides routes for the synthesis of “natural” δ-dodecalactone. The advantage of these routes is that they do not rely on massoia lactones. Massoia lactones are derived from the bark of Massoia trees which grow in Indonesia. Harvesting of the bark kills the trees.

The cytochrome P450 enzymes (P450s) claimed in this patent are to the inventors’ knowledge the most regioselective enzymes described thus far that can be used for the synthesis of δ-dodecalactone from lauric acid or 1-dodecanol. The approach that the technology takes is to claim cytochrome P450 enzymes that share 70 % amino acid identity to a set of selected P450s for the regioselective hydroxylation of lauric acid and 1-dodecanol to synthesise δ-dodecalactone.

Still in early stage

The current state of development is early stage with the technology only demonstrated in the laboratory on a small scale (100-200 ml). Before the technology can be commercialised the team would need to further improve the regioselectivity and stability of the P450s and proof that the reactions can be scaled up in bioreactors. The technology will probably be delivered as an enzyme (amino acid sequence) with the desired properties.

There are other research groups working on a synthetic biology approach for the de novo synthesis of δ-dodecalactone from glucose by genetically engineered microbes. It is still unclear how such a process will compare in terms of product yields, economics and environmental impact with the processes proposed by the UFS patent.

If the team had to partner with a commercial company, their first choice would be to work with an established flavour and fragrance company. Another possibility would be the small French flavour and fragrance company that Dr Alizé Pennec, the post-doc and co-inventor who initially discovered the unique P450 activity, is working for.

Please view the videos for more information on patents.

The Vice-Rector: Research and Internationalisation has released two new calls for applications for funding. Academic staff and researchers are encouraged to submit applications for these funds. At this stage we are not accepting projects from Research Fellows.

The two funds are:

1. The Industrial Engagement Fund

2. The Intellectual Property Commercialisation Fund

Each fund has its own guidelines and application process. The guidelines are attached. The applications must be filled in on RIMS.

The RIMS application forms can be found through this link

For more information please click the documents below:

IP Commercialisation Fund Concept Note

The UFS Industry Engagement Fund Concept Note

News Archive

The UFS #FaceOfFacebook

2014-11-14

At the UFS, we are committed to our Human Project, which sets the standard for good behaviour and care. It reaches internally to our students and externally to our prospective students and our communities.

And so, the Kovsies #FaceOfFacebook was born from the need to communicate with students and thus become a virtual friend. Yearly auditions are held to choose the new face representing the UFS on Facebook. The successful candidate holds the title #FaceOfFacebook for the next 12 months, attending events and filming short video clips to post on our Facebook page.

We had a quick chat with our current #FaceOfFacebook, Katleho 'Blue' Letube …

Who is Blue?

"Media mistress, fashion phenom, diva divine darling, superwoman and lover of life.
I was born in a small town called Bothaville, where my mom and her side of the family are living . I started pre-school there, moved and completed my schooling career at St. Andrew's High School (a very proud S aint) in Welkom. That is where my dad and his side of the family are living . Also, I am a proud resident of House NJ vd Merwe and I am studying Governance and Political Transformation."

How do you balance everything you do?

"It's relatively easy for me to strike a balance between my academics, social life and leadership duties, because Jesus is at the centre of all that I do. He is my guide and my strength. However, I also take it upon myself to prioritise. Although I am a '' liker of things'' , I ensure that my academics are the priority and everything else falls into place perfectly."

Are you dating someone?

"Hahaha, wouldn't you just love to know? Well, yes I am off-market. I'm completely taken and I'm happy."

What drives you?

"I always feel the urge to expand myself by working harder, smarter, stronger, and more efficiently. If there's an extra mile to go, the strength inside me draws out the willingness and ability to go that extra mile."

What is it like being the #FaceOfFacebook?

"I have been privileged to be entrusted with this duty and I carry it out with pride and passion. Being the #FaceOfFacebook means you get to meet a new face on campus almost every day, because people recognis e you and want to know you better. This opportunity has opened many doors for me and has equipped me with skills that have allowed me to grow as an individual. Therefore I will forever be grateful."

Where are you going to be in five years from now?

"Five years from now I would like to see myself as a better person both personally and professionally, in a respectable and reputed position earned through my hard work and skills. However, do not be surprised if you see me as a presenter on Vuzu.TV."

Advice to prospective students?

"Do not be that pupil who enrolled at this awesome institute and never takes advantage of its kindness. The University of The Free State is an institution that offers an excessive amount of opportunities to students. Step up and get out of your comfort zone. See an opportunity, seek the opportunity and cease it. You are at a university that provides you with a platform for you to grow."

What's your favourite colour?

My favourite colours are Black, White and Blue – hahaha!!

Kovsies can keep in touch:

Facebook: Katlego Blue Letube
Twitter: @Princess_blue31
Instagram: katlegoletube

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