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UFS busy with exciting research into flavours and fragrances

11 July 2022 | Story Andre Damons | Photo Supplied

Prof Martie Smith and Prof Drik Opperman — Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

Flavours and fragrances have a wide application in the food, feed, cosmetic, chemical and pharmaceutical sectors. Many flavour compounds are still produced via chemical synthesis or via extraction from plant or animal sources. However, there is increasing interest in their bio-production or the use of flavour compounds of (micro) biological origin.

One reason for this shift is that chemical synthesis often uses environmentally unfriendly processes. Chemical synthesis usually also produces racemic mixtures with the second enantiomer, mirror image of the looked-for compound, often having undesirable organoleptic properties. Furthermore, the consumer has developed a “chemophobia”-attitude towards synthetic chemical compounds, especially when related to food and home-care products. This applies even to nature-identical compounds – products that occur in nature but are produced via a non-natural chemical process. Products produced with the use of enzymes or microbes from “natural” substrates can be labelled “natural”. The flavour and fragrance industry thus pay higher prices for such products labelled as “natural”.

The invention

A University of the Free State (UFS) team, led by Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry are conducting exciting research in this area. They filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

The invention relates to a process for the enzymatic in-chain hydroxylation of C12 to C16 fatty acids, alcohols, and alkanes. Hydroxylation of C12 fatty acid and alcohol provides routes for the synthesis of “natural” δ-dodecalactone. The advantage of these routes is that they do not rely on massoia lactones. Massoia lactones are derived from the bark of Massoia trees which grow in Indonesia. Harvesting of the bark kills the trees.

The cytochrome P450 enzymes (P450s) claimed in this patent are to the inventors’ knowledge the most regioselective enzymes described thus far that can be used for the synthesis of δ-dodecalactone from lauric acid or 1-dodecanol. The approach that the technology takes is to claim cytochrome P450 enzymes that share 70 % amino acid identity to a set of selected P450s for the regioselective hydroxylation of lauric acid and 1-dodecanol to synthesise δ-dodecalactone.

Still in early stage

The current state of development is early stage with the technology only demonstrated in the laboratory on a small scale (100-200 ml). Before the technology can be commercialised the team would need to further improve the regioselectivity and stability of the P450s and proof that the reactions can be scaled up in bioreactors. The technology will probably be delivered as an enzyme (amino acid sequence) with the desired properties.

There are other research groups working on a synthetic biology approach for the de novo synthesis of δ-dodecalactone from glucose by genetically engineered microbes. It is still unclear how such a process will compare in terms of product yields, economics and environmental impact with the processes proposed by the UFS patent.

If the team had to partner with a commercial company, their first choice would be to work with an established flavour and fragrance company. Another possibility would be the small French flavour and fragrance company that Dr Alizé Pennec, the post-doc and co-inventor who initially discovered the unique P450 activity, is working for.

Please view the videos for more information on patents.

The Vice-Rector: Research and Internationalisation has released two new calls for applications for funding. Academic staff and researchers are encouraged to submit applications for these funds. At this stage we are not accepting projects from Research Fellows.

The two funds are:

1. The Industrial Engagement Fund

2. The Intellectual Property Commercialisation Fund

Each fund has its own guidelines and application process. The guidelines are attached. The applications must be filled in on RIMS.

The RIMS application forms can be found through this link

For more information please click the documents below:

IP Commercialisation Fund Concept Note

The UFS Industry Engagement Fund Concept Note

News Archive

Kovsies to celebrate excellence at 2014 December Graduation Ceremony

2014-12-02

Live streaming: http://apps.ufs.ac.za/ufslivestreaming/

On Thursday 11 December 2014, the University of the Free State (UFS) will award degrees and qualifications during our Summer Graduation Ceremony at the Bloemfontein Campus.

The graduation will take place during two ceremonies in the Callie Human Centre, where master’s and PhD degrees will be awarded during the first ceremony at 09:30. Diplomas, certificates and undergraduate qualifications will be awarded to students from the School of Open Learning and the Faculty of Health Sciences at 14:30.

Radio personality, Redi Thlabi, and cardiothoracic surgeon, Dr Susan Vosloo, will address the graduates.

Apart from her radio show on 702 and CapeTalk, Thlabi has also hosted local television news shows and anchored for international broadcasters like SKY and the BBC. In addition, she has presented two of her own TV shows: ‘Redi’ on Mzansi Magic and ‘South to North’ on Al-Jazeera.

Her first book, Endings and Beginnings (Jacana) received popular acclaim and is currently being turned into a screenplay for a movie.

Dr Susan Vosloo, a Kovsie alumnus, graduated in 1980. She completed her internship in Pretoria and spent the following year in Critical Care Medicine at Universitas Hospital, Bloemfontein, before starting her surgical training in Johannesburg.

She is currently in independent private practice at the Netcare Christiaan Barnard Memorial Hospital in Cape Town, having also worked from 1998 – 2012 at the Vincent Pallotti Hospital in the same city.

Dr Vosloo maintains close ties with our university and has quite a number of addition roles to that of surgeon:

• member of the Council of the UFS;
• UFS Council Representative in the Senate;
• member of the Standing Advisory Committee of the School of Medicine, UFS;
• member of the Provincial Department of Health;
• Africa representative for the Pediatric Cardiac Intensive Care Society; and
• founding member of the World Society for Pediatric and Congenital Heart Surgery.

Prof Boelie Wessels will also be awarded his 10th academic degree from the UFS since 1974. Adding his Honorary Doctorate degree to the list, it will make this his 11th degree. Prof Wessels is 84 years old and has 18-plus academic qualifications from various institutions – a phenomenal achievement.

Furthermore, Moses Lubinga and his wife, Stellah, will be the first married couple to be awarded their PhDs at the same graduation ceremony at the UFS. Mr Lubinga will receive his Doctorate in Agricultural Economics, while Mrs Lubinga’s PhD is in the field of Economic and Management Sciences.

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