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Prof Martie Smith and Prof Drik Opperman
Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

Flavours and fragrances have a wide application in the food, feed, cosmetic, chemical and pharmaceutical sectors. Many flavour compounds are still produced via chemical synthesis or via extraction from plant or animal sources. However, there is increasing interest in their bio-production or the use of flavour compounds of (micro) biological origin. 

One reason for this shift is that chemical synthesis often uses environmentally unfriendly processes. Chemical synthesis usually also produces racemic mixtures with the second enantiomer, mirror image of the looked-for compound, often having undesirable organoleptic properties. Furthermore, the consumer has developed a “chemophobia”-attitude towards synthetic chemical compounds, especially when related to food and home-care products.  This applies even to nature-identical compounds – products that occur in nature but are produced via a non-natural chemical process. Products produced with the use of enzymes or microbes from “natural” substrates can be labelled “natural”. The flavour and fragrance industry thus pay higher prices for such products labelled as “natural”.  

The invention

A University of the Free State (UFS) team, led by Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry are conducting exciting research in this area. They filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.  

The invention relates to a process for the enzymatic in-chain hydroxylation of C12 to C16 fatty acids, alcohols, and alkanes. Hydroxylation of C12 fatty acid and alcohol provides routes for the synthesis of “natural” δ-dodecalactone. The advantage of these routes is that they do not rely on massoia lactones. Massoia lactones are derived from the bark of Massoia trees which grow in Indonesia. Harvesting of the bark kills the trees.  

The cytochrome P450 enzymes (P450s) claimed in this patent are to the inventors’ knowledge the most regioselective enzymes described thus far that can be used for the synthesis of δ-dodecalactone from lauric acid or 1-dodecanol. The approach that the technology takes is to claim cytochrome P450 enzymes that share 70 % amino acid identity to a set of selected P450s for the regioselective hydroxylation of lauric acid and 1-dodecanol to synthesise δ-dodecalactone.

Still in early stage

The current state of development is early stage with the technology only demonstrated in the laboratory on a small scale (100-200 ml). Before the technology can be commercialised the team would need to further improve the regioselectivity and stability of the P450s and proof that the reactions can be scaled up in bioreactors. The technology will probably be delivered as an enzyme (amino acid sequence) with the desired properties. 

There are other research groups working on a synthetic biology approach for the de novo synthesis of δ-dodecalactone from glucose by genetically engineered microbes. It is still unclear how such a process will compare in terms of product yields, economics and environmental impact with the processes proposed by the UFS patent.

If the team had to partner with a commercial company, their first choice would be to work with an established flavour and fragrance company. Another possibility would be the small French flavour and fragrance company that Dr Alizé Pennec, the post-doc and co-inventor who initially discovered the unique P450 activity, is working for.

Please view the videos for more information on patents.

The Vice-Rector: Research and Internationalisation has released two new calls for applications for funding. Academic staff and researchers are encouraged to submit applications for these funds. At this stage we are not accepting projects from Research Fellows. 

The two funds are: 

1.  The Industrial Engagement Fund 
2.  The Intellectual Property Commercialisation Fund

Each fund has its own guidelines and application process. The guidelines are attached. The applications must be filled in on RIMS.

The RIMS application forms can be found through this link

For more information please click the documents below:



News Archive

Music programme receives a boost
2004-08-20

 

 

Back standing fltr: Mr Peter Guy - Founder and coordinator: Mangaung String Program and snr lecturer at the Musicon; Mrs Francine Duvenage, Manager: Human Resources, Wesbank. Middle fltr: Prof Frederick Fourie, Rector and Vice-Chancellor of the UFS; Mr Apie Otto, Area Manager: Vehicles, Wesbank Free State and Northern Cape. Front fltr: Mr John Minaar (17), Gr 12 Sand du Plessis Secondary School; Repiloe Olifant (14) Gr 10 Navalsig Secondary School; Moeketsi Khang (16) Gr 11 Tsoseletso Secondary School; Stella Benbooi (12) Gr 7 Bochabela Primary School.

The Mangaung String Programme, a partnership between the University of the Free State (UFS) and the Free State Musicon, an institution that falls under the auspices of the Free State Department of Sport, Arts, Culture, Science and Technology, has recently received heartened encouragement when an amount of R342 000,00 was granted to the programme by the Wesbank/First Rand Foundation for the purchasing of a bus.

“Transporting the children who are part of the programme back and forth for tuition and rehearsals has been a major problem as most of them stay in the townships on the outskirts of Bloemfontein ,” said Mr Peter Guy, founder and coordinator of the programme.

“The bus will ensure that those children who have the passion, dedication and commitment can spend every afternoon if they so choose practicing, learning about music and rehearsing with children from all over Bloemfontein,” said Mr Guy.

Mr Guy, a Senior Lecturer at the Musicon, started the programme in 1998 with funding from the Musicon Parents Teachers Association, initially with 15 pupils - today 150 children participate in the programme. In 2002 the UFS formed a partnership with the Free State Musicon in the provisioning of facilities, tuition and musical instruments. “Since the involvement of the UFS, the programme has almost tripled in size and one

fulltime teaching position is now jointly funded by both institutions,” said Mr Guy.

According to Mr Guy the Free State Symphony Orchestra has committed itself to providing opportunities for gifted young players from all backgrounds to perform, develop their talents and to grow musically. Some of the children of the Mangaung String Programme will soon be joining the Free State Symphony Concert in concerts.

Media Release
Issued by: Lacea Loader
Media Representative
Tel: (051) 401-2584
Cell: 083 645 2454
E-mail: loaderl.stg@mail.uovs.ac.za
19 August 2004
 

 

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