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Prof Martie Smith and Prof Drik Opperman
Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

Flavours and fragrances have a wide application in the food, feed, cosmetic, chemical and pharmaceutical sectors. Many flavour compounds are still produced via chemical synthesis or via extraction from plant or animal sources. However, there is increasing interest in their bio-production or the use of flavour compounds of (micro) biological origin. 

One reason for this shift is that chemical synthesis often uses environmentally unfriendly processes. Chemical synthesis usually also produces racemic mixtures with the second enantiomer, mirror image of the looked-for compound, often having undesirable organoleptic properties. Furthermore, the consumer has developed a “chemophobia”-attitude towards synthetic chemical compounds, especially when related to food and home-care products.  This applies even to nature-identical compounds – products that occur in nature but are produced via a non-natural chemical process. Products produced with the use of enzymes or microbes from “natural” substrates can be labelled “natural”. The flavour and fragrance industry thus pay higher prices for such products labelled as “natural”.  

The invention

A University of the Free State (UFS) team, led by Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry are conducting exciting research in this area. They filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.  

The invention relates to a process for the enzymatic in-chain hydroxylation of C12 to C16 fatty acids, alcohols, and alkanes. Hydroxylation of C12 fatty acid and alcohol provides routes for the synthesis of “natural” δ-dodecalactone. The advantage of these routes is that they do not rely on massoia lactones. Massoia lactones are derived from the bark of Massoia trees which grow in Indonesia. Harvesting of the bark kills the trees.  

The cytochrome P450 enzymes (P450s) claimed in this patent are to the inventors’ knowledge the most regioselective enzymes described thus far that can be used for the synthesis of δ-dodecalactone from lauric acid or 1-dodecanol. The approach that the technology takes is to claim cytochrome P450 enzymes that share 70 % amino acid identity to a set of selected P450s for the regioselective hydroxylation of lauric acid and 1-dodecanol to synthesise δ-dodecalactone.

Still in early stage

The current state of development is early stage with the technology only demonstrated in the laboratory on a small scale (100-200 ml). Before the technology can be commercialised the team would need to further improve the regioselectivity and stability of the P450s and proof that the reactions can be scaled up in bioreactors. The technology will probably be delivered as an enzyme (amino acid sequence) with the desired properties. 

There are other research groups working on a synthetic biology approach for the de novo synthesis of δ-dodecalactone from glucose by genetically engineered microbes. It is still unclear how such a process will compare in terms of product yields, economics and environmental impact with the processes proposed by the UFS patent.

If the team had to partner with a commercial company, their first choice would be to work with an established flavour and fragrance company. Another possibility would be the small French flavour and fragrance company that Dr Alizé Pennec, the post-doc and co-inventor who initially discovered the unique P450 activity, is working for.

Please view the videos for more information on patents.

The Vice-Rector: Research and Internationalisation has released two new calls for applications for funding. Academic staff and researchers are encouraged to submit applications for these funds. At this stage we are not accepting projects from Research Fellows. 

The two funds are: 

1.  The Industrial Engagement Fund 
2.  The Intellectual Property Commercialisation Fund

Each fund has its own guidelines and application process. The guidelines are attached. The applications must be filled in on RIMS.

The RIMS application forms can be found through this link

For more information please click the documents below:



News Archive

UFS mourns the death of a great academic
2007-02-27

 

It is with great sadness that the management of the University of the Free State (UFS) heard of the death of Prof. Dawfré Roode.

Prof. Roode (70) was the first Registrar: Academics at the UFS. He retired in July 1997 and was living in Jeffrey’s Bay with his second wife, Daphne, for the past three years.

Prof Roode’s ties with the UFS stretch over more than fifty years. He registered at the UOFS in 1955 as first-year student and was elected as chairperson of the student representative council in 1958. He also represented the university on the cricket field and as Free State nineteen-year old in the Currie Cup. His academic career at the UOFS started in 1963 when he was appointed as lecturer in Sociology and Social Work. After completing his D Phil in 1964, he was promoted to senior lecturer in 1966. He became the first head of the Department of Sociology in 1972 and in 1989 he was appointed as Registrar: Academics and in 1989 Vice-Rector: Staff and Administration.

“Prof Roode brought professionalism to the administration that did not exist. He not only served the academe as registrar, but also established it as an important function within the UOFS. His ‘institutional memory’ about earlier decisions and events at the UOFS is also legendary,” said Prof Frederick Fourie, Rector and Vice-Chancellor at the UFS.

Prof Roode’s father, the late Prof Dawie Roode, was the first head of the Department of Music at the UFS. Prof Dawfré Roode had a love for music and was closely involved with the establishment of the Odeion String Quartet.

In October 2004 the university honoured him with a Centenary Medal for his outstanding leadership and contribution, as Registrar and Vice-Rector, to the development of the UFS by establishing and developing a strong and professional administrative structure at the UFS.

“Prof Roode left deep footprints at the UFS. I am glad that we could honour him for this in 2004 with a Centenary Medal before he passed away. He also attended the launch of the university’s history book earlier in February,” said Prof Fourie.

“Our sympathies go to Ms Trudie Roode (his first wife) and their three children Ms Frelet Roux and Gerda Daffue, and their son, Mr Dawie Roode. Prof Roode has left a gap in the hearts of the people who knew and worked with him at the UFS,” said Prof Fourie.

A memorial service will be held in Jeffrey’s Bay on Wednesday 28 February 2007 at 10:30. A memorial service will also be held in Bloemfontein on Wednesday 7 March 2007. More details will be made available at a later stage.
 

Media release
Issued by: Lacea Loader
Media Representative
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@mail.uovs.ac.za
27 February 2007

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