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11 July 2022 | Story Andre Damons | Photo Supplied
Prof Martie Smith and Prof Drik Opperman
Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

Flavours and fragrances have a wide application in the food, feed, cosmetic, chemical and pharmaceutical sectors. Many flavour compounds are still produced via chemical synthesis or via extraction from plant or animal sources. However, there is increasing interest in their bio-production or the use of flavour compounds of (micro) biological origin. 

One reason for this shift is that chemical synthesis often uses environmentally unfriendly processes. Chemical synthesis usually also produces racemic mixtures with the second enantiomer, mirror image of the looked-for compound, often having undesirable organoleptic properties. Furthermore, the consumer has developed a “chemophobia”-attitude towards synthetic chemical compounds, especially when related to food and home-care products.  This applies even to nature-identical compounds – products that occur in nature but are produced via a non-natural chemical process. Products produced with the use of enzymes or microbes from “natural” substrates can be labelled “natural”. The flavour and fragrance industry thus pay higher prices for such products labelled as “natural”.  

The invention

A University of the Free State (UFS) team, led by Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry are conducting exciting research in this area. They filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.  

The invention relates to a process for the enzymatic in-chain hydroxylation of C12 to C16 fatty acids, alcohols, and alkanes. Hydroxylation of C12 fatty acid and alcohol provides routes for the synthesis of “natural” δ-dodecalactone. The advantage of these routes is that they do not rely on massoia lactones. Massoia lactones are derived from the bark of Massoia trees which grow in Indonesia. Harvesting of the bark kills the trees.  

The cytochrome P450 enzymes (P450s) claimed in this patent are to the inventors’ knowledge the most regioselective enzymes described thus far that can be used for the synthesis of δ-dodecalactone from lauric acid or 1-dodecanol. The approach that the technology takes is to claim cytochrome P450 enzymes that share 70 % amino acid identity to a set of selected P450s for the regioselective hydroxylation of lauric acid and 1-dodecanol to synthesise δ-dodecalactone.

Still in early stage

The current state of development is early stage with the technology only demonstrated in the laboratory on a small scale (100-200 ml). Before the technology can be commercialised the team would need to further improve the regioselectivity and stability of the P450s and proof that the reactions can be scaled up in bioreactors. The technology will probably be delivered as an enzyme (amino acid sequence) with the desired properties. 

There are other research groups working on a synthetic biology approach for the de novo synthesis of δ-dodecalactone from glucose by genetically engineered microbes. It is still unclear how such a process will compare in terms of product yields, economics and environmental impact with the processes proposed by the UFS patent.

If the team had to partner with a commercial company, their first choice would be to work with an established flavour and fragrance company. Another possibility would be the small French flavour and fragrance company that Dr Alizé Pennec, the post-doc and co-inventor who initially discovered the unique P450 activity, is working for.

Please view the videos for more information on patents.

The Vice-Rector: Research and Internationalisation has released two new calls for applications for funding. Academic staff and researchers are encouraged to submit applications for these funds. At this stage we are not accepting projects from Research Fellows. 

The two funds are: 

1.  The Industrial Engagement Fund 
2.  The Intellectual Property Commercialisation Fund

Each fund has its own guidelines and application process. The guidelines are attached. The applications must be filled in on RIMS.

The RIMS application forms can be found through this link

For more information please click the documents below:



News Archive

UFS mourns the death of valued Member of Council
2015-05-15

Father Patrick Towe

The senior leadership of the University of the Free State (UFS) is deeply saddened by the passing away of Father Patrick Towe on Wednesday 6 May 2015, following a period of illness. Father Towe served as Chairperson of the university’s Campus Ministries Forum (CMF) for several years, and had been its representative on the UFS Council since 2006.

“Father Towe was an extremely valuable member of the UFS Council. His insight into and knowledge of university business always contributed greatly to the spirit in which the deliberations of Council took place. He will be dearly missed. Our deepest condolences go to his family, friends, the students of ACTS, as well as the congregation in Heidedal, which he served,” said Judge Ian van der Merwe, Chairperson of the UFS Council.

“I remember Father Towe fondly for his pastoral availability to staff and students during moments of crisis from the time of the Reitz incident to those times in which we lost precious student lives. He would call us to prayer and consolation, and for these gifts from Father Towe I am deeply, deeply grateful,” said Prof Jonathan Jansen, Vice-Chancellor and Rector of the UFS.

Father Towe, OMI (Missionary Oblates of Mary Immaculate) represented the Association of Catholic Tertiary Students (ACTS) on the Campus Ministries Forum. As Student Chaplain, he served the university student body through the Catholic Christian Ministry, providing spiritual guidance and support. He took up campus ministry in Bloemfontein in November 2002, and developed a quasi-parish within the student communities on campus.

He received his education in the United Kingdom where he was ordained in 1975. Throughout his career, Father Towe had a special involvement with community development and youth work. He worked as the Roman Catholic Chaplain at the University of Southampton from 1996 to 1998, providing pastoral care to both students and staff of the university. He served as Parish Priest of Christ the King in Heidedal, Bloemfontein.

“Father Towe was instrumental in reviving the CMF, and getting many more churches on campus involved. He had a heart for seeing churches with different backgrounds and focuses unite in making a difference at the university. He was a true gentleman, and was willing to listen to and negotiate with people, without compromising his values. He also did great work among the people of Heidedal towards the end of his life, and we will miss his presence on the CMF”, said Pastor Alistair Kingwill, current Chairperson of the CMF.

 

Media Release
Lacea Loader
Director: Communication and Brand Management
Tel: +27(0)51 401 2584
E-mail: news@ufs.ac.za

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