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11 July 2022 | Story Andre Damons | Photo Supplied
Prof Martie Smith and Prof Drik Opperman
Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

Flavours and fragrances have a wide application in the food, feed, cosmetic, chemical and pharmaceutical sectors. Many flavour compounds are still produced via chemical synthesis or via extraction from plant or animal sources. However, there is increasing interest in their bio-production or the use of flavour compounds of (micro) biological origin. 

One reason for this shift is that chemical synthesis often uses environmentally unfriendly processes. Chemical synthesis usually also produces racemic mixtures with the second enantiomer, mirror image of the looked-for compound, often having undesirable organoleptic properties. Furthermore, the consumer has developed a “chemophobia”-attitude towards synthetic chemical compounds, especially when related to food and home-care products.  This applies even to nature-identical compounds – products that occur in nature but are produced via a non-natural chemical process. Products produced with the use of enzymes or microbes from “natural” substrates can be labelled “natural”. The flavour and fragrance industry thus pay higher prices for such products labelled as “natural”.  

The invention

A University of the Free State (UFS) team, led by Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry are conducting exciting research in this area. They filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.  

The invention relates to a process for the enzymatic in-chain hydroxylation of C12 to C16 fatty acids, alcohols, and alkanes. Hydroxylation of C12 fatty acid and alcohol provides routes for the synthesis of “natural” δ-dodecalactone. The advantage of these routes is that they do not rely on massoia lactones. Massoia lactones are derived from the bark of Massoia trees which grow in Indonesia. Harvesting of the bark kills the trees.  

The cytochrome P450 enzymes (P450s) claimed in this patent are to the inventors’ knowledge the most regioselective enzymes described thus far that can be used for the synthesis of δ-dodecalactone from lauric acid or 1-dodecanol. The approach that the technology takes is to claim cytochrome P450 enzymes that share 70 % amino acid identity to a set of selected P450s for the regioselective hydroxylation of lauric acid and 1-dodecanol to synthesise δ-dodecalactone.

Still in early stage

The current state of development is early stage with the technology only demonstrated in the laboratory on a small scale (100-200 ml). Before the technology can be commercialised the team would need to further improve the regioselectivity and stability of the P450s and proof that the reactions can be scaled up in bioreactors. The technology will probably be delivered as an enzyme (amino acid sequence) with the desired properties. 

There are other research groups working on a synthetic biology approach for the de novo synthesis of δ-dodecalactone from glucose by genetically engineered microbes. It is still unclear how such a process will compare in terms of product yields, economics and environmental impact with the processes proposed by the UFS patent.

If the team had to partner with a commercial company, their first choice would be to work with an established flavour and fragrance company. Another possibility would be the small French flavour and fragrance company that Dr Alizé Pennec, the post-doc and co-inventor who initially discovered the unique P450 activity, is working for.

Please view the videos for more information on patents.

The Vice-Rector: Research and Internationalisation has released two new calls for applications for funding. Academic staff and researchers are encouraged to submit applications for these funds. At this stage we are not accepting projects from Research Fellows. 

The two funds are: 

1.  The Industrial Engagement Fund 
2.  The Intellectual Property Commercialisation Fund

Each fund has its own guidelines and application process. The guidelines are attached. The applications must be filled in on RIMS.

The RIMS application forms can be found through this link

For more information please click the documents below:



News Archive

The science of translation
2015-09-16

What is the relationship between a translator, information, and an audience? Professor Christiane Nord explored the connection in a series of lectures hosted by the Linguistics and Language Practice Department and the Department of Hebrew of the University of the Free State (UFS) Bloemfontein Campus.

Since 2007, the professor for Translation Studies has been a research associate and professor extraordinary in the department, assisting translation and interpreting students in gaining a global perspective on their disciplines.

The world-renowned German scholar and trained translator for Spanish and English is also an author, with over 200 published articles on the so-called Skopos Theory, which formed the basis of the lectures on 7 and 8 September 2015. The addresses were centered on the functionality and limitations of translations.

Translation as a purposeful activity

According to Prof Nord, all translations should be geared towards conveying messages which the audience understands. This communicative purpose involves taking into consideration the cultural background of the recipient.

As a seasoned practitioner, Prof Nord has been guided by Skopos Theory in her teaching endeavours. Hence her firm stance: “If you do not have a theory, you cannot justify your translational decisions.”

Within the context of the Skopos Theory, she explains that, in order to produce a functional translation, the translator must analyse the purpose of the translated text, which includes the questions for whom, when, where, and through which medium will it reach the intended audience.

How to deal with doubt in functional translation

“Doubt is something we are accompanied by when we’re translating.” Such doubt may be caused by “insufficient proficiency with regards to source and target languages and cultures, domain and terminological knowledge, and knowledge in translation theory and methodology,” said Prof Nord. However, the top-down approach offers a solution to overcome uncertainty, at least to some extent. This approach considers, first and foremost, the target audience for which the translation is tailored. Based on this consideration, the translator is able to determine the approach that is most suitable for the audience, hence eliminating doubt.

In sum, the extraordinary professor asserted that there are no rules for translation, contrary to popular belief. According to Prof Nord, the main focus of a translator or interpreter should be to produce texts in the target language and culture which meet the requirements of the translation brief set by the client or commissioner.

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