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UFS busy with exciting research into flavours and fragrances

11 July 2022 | Story Andre Damons | Photo Supplied

Prof Martie Smith and Prof Drik Opperman — Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

Flavours and fragrances have a wide application in the food, feed, cosmetic, chemical and pharmaceutical sectors. Many flavour compounds are still produced via chemical synthesis or via extraction from plant or animal sources. However, there is increasing interest in their bio-production or the use of flavour compounds of (micro) biological origin.

One reason for this shift is that chemical synthesis often uses environmentally unfriendly processes. Chemical synthesis usually also produces racemic mixtures with the second enantiomer, mirror image of the looked-for compound, often having undesirable organoleptic properties. Furthermore, the consumer has developed a “chemophobia”-attitude towards synthetic chemical compounds, especially when related to food and home-care products. This applies even to nature-identical compounds – products that occur in nature but are produced via a non-natural chemical process. Products produced with the use of enzymes or microbes from “natural” substrates can be labelled “natural”. The flavour and fragrance industry thus pay higher prices for such products labelled as “natural”.

The invention

A University of the Free State (UFS) team, led by Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry are conducting exciting research in this area. They filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

The invention relates to a process for the enzymatic in-chain hydroxylation of C12 to C16 fatty acids, alcohols, and alkanes. Hydroxylation of C12 fatty acid and alcohol provides routes for the synthesis of “natural” δ-dodecalactone. The advantage of these routes is that they do not rely on massoia lactones. Massoia lactones are derived from the bark of Massoia trees which grow in Indonesia. Harvesting of the bark kills the trees.

The cytochrome P450 enzymes (P450s) claimed in this patent are to the inventors’ knowledge the most regioselective enzymes described thus far that can be used for the synthesis of δ-dodecalactone from lauric acid or 1-dodecanol. The approach that the technology takes is to claim cytochrome P450 enzymes that share 70 % amino acid identity to a set of selected P450s for the regioselective hydroxylation of lauric acid and 1-dodecanol to synthesise δ-dodecalactone.

Still in early stage

The current state of development is early stage with the technology only demonstrated in the laboratory on a small scale (100-200 ml). Before the technology can be commercialised the team would need to further improve the regioselectivity and stability of the P450s and proof that the reactions can be scaled up in bioreactors. The technology will probably be delivered as an enzyme (amino acid sequence) with the desired properties.

There are other research groups working on a synthetic biology approach for the de novo synthesis of δ-dodecalactone from glucose by genetically engineered microbes. It is still unclear how such a process will compare in terms of product yields, economics and environmental impact with the processes proposed by the UFS patent.

If the team had to partner with a commercial company, their first choice would be to work with an established flavour and fragrance company. Another possibility would be the small French flavour and fragrance company that Dr Alizé Pennec, the post-doc and co-inventor who initially discovered the unique P450 activity, is working for.

Please view the videos for more information on patents.

The Vice-Rector: Research and Internationalisation has released two new calls for applications for funding. Academic staff and researchers are encouraged to submit applications for these funds. At this stage we are not accepting projects from Research Fellows.

The two funds are:

1. The Industrial Engagement Fund

2. The Intellectual Property Commercialisation Fund

Each fund has its own guidelines and application process. The guidelines are attached. The applications must be filled in on RIMS.

The RIMS application forms can be found through this link

For more information please click the documents below:

IP Commercialisation Fund Concept Note

The UFS Industry Engagement Fund Concept Note

News Archive

UFS Centenary celebrations come to an end

2005-02-03

OFFICIAL OPENING

The official opening of the UFS will take place on Friday 04 February 2005 at 09:00 in the Reitz Hall (Centenary Complex). Please note that this is a test and lecture free day. The Rector and Vice-Chancellor, Prof. Frederick Fourie will be the keynote speaker. Refreshments will be served at the Centenary Complex after the opening ceremony.

The historic Centenary photograph will be taken at 11:00 on the eastern side of the Red Square (CR Swart parking area). All staff members and students are invited to be part of this massive photograph.

Important

• There will be no parking allowed on the CR Swart parking area until 12:00 on Friday 04 February 2005, as a result of the photo session.

• All academic staff members are requested to wear academic dress on the day, seeing as staff members will depict the Centenary emblem on the photograph. Academic gowns may be collected from the Gown Store on Wednesday 02 - Thursday 03 February 2005 between 08:00 and 16:00. Gowns must be returned to the Gown Store after the photograph has been taken.

SERVICE OF DEVOTION

A special service of devotion will take place on Sunday 06 February 2005 at 18:00 for 18:30 in front of the Main Building on the Red Square. This is a special gathering of students, hosted by all the interdenominational groups on the UFS campus. The evening will be a celebration of praise, thanks and worship, followed by a message from Dr Wollie Grobler. The evening will conclude with song and fireworks.

Staff members and students are welcome to bring their friends and families to this special event.

Important

• Even though there will be chairs in front of the Main Building, staff members and students are requested to bring extra pillows and blankets to sit on.

• No persons or vehicles will be allowed on the eastern side of the Red Square or on the CR Swart parking area, due to the security requirements of the fireworks show.

• All members of the choir are invited to be part of the mass choir. Lyrics will be provided.

• All persons who attend this event are requested to bring a candle for the purpose of the mass choir.

• Special transportation arrangements will be made for all service workers to enable them to attend the service. If there is someone in your faculty, department or division who would like to make use of this service, please send an e-mail to Elize Rall (ralle.stg@mail.uovs.ac.za) no later than Tuesday 01 February 2005.

OTHER ACTIVITIES

• A reunion for all former SRC members of the UFS will take place on the campus, from 04 February to 06 February 2005. An interesting programme is being planned. For more information, please contact Nicolaas du Plessis on 084 955 0875.

• The annual Rag Procession will take place on Saturday 05 February 2005. For more information, contact the Rag Office at X 2718.

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