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11 July 2022 | Story Andre Damons | Photo Supplied
Prof Martie Smith and Prof Drik Opperman
Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

Flavours and fragrances have a wide application in the food, feed, cosmetic, chemical and pharmaceutical sectors. Many flavour compounds are still produced via chemical synthesis or via extraction from plant or animal sources. However, there is increasing interest in their bio-production or the use of flavour compounds of (micro) biological origin. 

One reason for this shift is that chemical synthesis often uses environmentally unfriendly processes. Chemical synthesis usually also produces racemic mixtures with the second enantiomer, mirror image of the looked-for compound, often having undesirable organoleptic properties. Furthermore, the consumer has developed a “chemophobia”-attitude towards synthetic chemical compounds, especially when related to food and home-care products.  This applies even to nature-identical compounds – products that occur in nature but are produced via a non-natural chemical process. Products produced with the use of enzymes or microbes from “natural” substrates can be labelled “natural”. The flavour and fragrance industry thus pay higher prices for such products labelled as “natural”.  

The invention

A University of the Free State (UFS) team, led by Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry are conducting exciting research in this area. They filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.  

The invention relates to a process for the enzymatic in-chain hydroxylation of C12 to C16 fatty acids, alcohols, and alkanes. Hydroxylation of C12 fatty acid and alcohol provides routes for the synthesis of “natural” δ-dodecalactone. The advantage of these routes is that they do not rely on massoia lactones. Massoia lactones are derived from the bark of Massoia trees which grow in Indonesia. Harvesting of the bark kills the trees.  

The cytochrome P450 enzymes (P450s) claimed in this patent are to the inventors’ knowledge the most regioselective enzymes described thus far that can be used for the synthesis of δ-dodecalactone from lauric acid or 1-dodecanol. The approach that the technology takes is to claim cytochrome P450 enzymes that share 70 % amino acid identity to a set of selected P450s for the regioselective hydroxylation of lauric acid and 1-dodecanol to synthesise δ-dodecalactone.

Still in early stage

The current state of development is early stage with the technology only demonstrated in the laboratory on a small scale (100-200 ml). Before the technology can be commercialised the team would need to further improve the regioselectivity and stability of the P450s and proof that the reactions can be scaled up in bioreactors. The technology will probably be delivered as an enzyme (amino acid sequence) with the desired properties. 

There are other research groups working on a synthetic biology approach for the de novo synthesis of δ-dodecalactone from glucose by genetically engineered microbes. It is still unclear how such a process will compare in terms of product yields, economics and environmental impact with the processes proposed by the UFS patent.

If the team had to partner with a commercial company, their first choice would be to work with an established flavour and fragrance company. Another possibility would be the small French flavour and fragrance company that Dr Alizé Pennec, the post-doc and co-inventor who initially discovered the unique P450 activity, is working for.

Please view the videos for more information on patents.

The Vice-Rector: Research and Internationalisation has released two new calls for applications for funding. Academic staff and researchers are encouraged to submit applications for these funds. At this stage we are not accepting projects from Research Fellows. 

The two funds are: 

1.  The Industrial Engagement Fund 
2.  The Intellectual Property Commercialisation Fund

Each fund has its own guidelines and application process. The guidelines are attached. The applications must be filled in on RIMS.

The RIMS application forms can be found through this link

For more information please click the documents below:



News Archive

Heidedal-based foundation and UFS host inaugural music concert
2015-12-04

ROC children rock in marimba music
Photo: Valentino Ndaba

Reach Our Community (ROC) Foundation in conjunction with the University of the Free State’s Odeion School of Music (OSM) held its first-ever music concert last month. Children who form part of the foundation’s Afterschool Care programme showed their impressive music skills to their parents and guardians in attendance.

ROC provides support to orphaned and vulnerable children from early childhood through to adolescence in the Heidedal community in Bloemfontein. The foundation strives to address the challenges resulting from factors such as poverty, unemployment, HIV/Aids, single parenting, lack of guardianship, and physical and sexual abuse. In the Afterschool Care programme, the children engage in educational, cultural, and recreational activities.

Going the extra mile

Since 2008, the UFS has successfully partnered with ROC through service learning and community engagement in which students from across all seven faculties participate. Two Music Education and Practice students from the OSM took it upon themselves to continue after their curriculum requirements were met.

Amy Viljoen- now a final-year BMus student, together with fellow student, Petre du Plessis, and their lecturer and programme coordinator, Gerda Pretorius, established the music class project in Heidedal in 2014. The students embarked on weekly trips to ROC, and would spend an hour working on the recorders and marimbas with children from ROC.

This year, Viljoen and Kara-Lynn Crankshaw, a final-year BA Music student, spent eleven months teaching the children music practice and theory, culminating in a concert that both the community and students can be proud of.

“I wanted to do something that was not only meant for educational purposes, but to give back to the community,” said Viljoen.

After having to gather extra chairs because of the influx of community members at the ROC hall, the founder, Patrick Kaars, said he had not expected such a turn-out. “It exceeded my expectations, and it was a dream come true. It meant so much to the children to be exposed to music, and to explore their own capabilities and talents.”

More children will learn how to play other instruments. Currently, the instruments used for the children’s training were purchased second-hand in order to cut costs. New music education specialists, who will join the programme in 2016, will also work with Pretorius to gather additional equipment, and compile learning material.

Kaars is also thrilled about the potential expansion to the music group, now that the concert has become an annual event. The OSM is also in the process of establishing a Centre for Music Development at ROC.

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