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UFS busy with exciting research into flavours and fragrances

11 July 2022 | Story Andre Damons | Photo Supplied

Prof Martie Smith and Prof Drik Opperman — Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

Flavours and fragrances have a wide application in the food, feed, cosmetic, chemical and pharmaceutical sectors. Many flavour compounds are still produced via chemical synthesis or via extraction from plant or animal sources. However, there is increasing interest in their bio-production or the use of flavour compounds of (micro) biological origin.

One reason for this shift is that chemical synthesis often uses environmentally unfriendly processes. Chemical synthesis usually also produces racemic mixtures with the second enantiomer, mirror image of the looked-for compound, often having undesirable organoleptic properties. Furthermore, the consumer has developed a “chemophobia”-attitude towards synthetic chemical compounds, especially when related to food and home-care products. This applies even to nature-identical compounds – products that occur in nature but are produced via a non-natural chemical process. Products produced with the use of enzymes or microbes from “natural” substrates can be labelled “natural”. The flavour and fragrance industry thus pay higher prices for such products labelled as “natural”.

The invention

A University of the Free State (UFS) team, led by Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry are conducting exciting research in this area. They filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

The invention relates to a process for the enzymatic in-chain hydroxylation of C12 to C16 fatty acids, alcohols, and alkanes. Hydroxylation of C12 fatty acid and alcohol provides routes for the synthesis of “natural” δ-dodecalactone. The advantage of these routes is that they do not rely on massoia lactones. Massoia lactones are derived from the bark of Massoia trees which grow in Indonesia. Harvesting of the bark kills the trees.

The cytochrome P450 enzymes (P450s) claimed in this patent are to the inventors’ knowledge the most regioselective enzymes described thus far that can be used for the synthesis of δ-dodecalactone from lauric acid or 1-dodecanol. The approach that the technology takes is to claim cytochrome P450 enzymes that share 70 % amino acid identity to a set of selected P450s for the regioselective hydroxylation of lauric acid and 1-dodecanol to synthesise δ-dodecalactone.

Still in early stage

The current state of development is early stage with the technology only demonstrated in the laboratory on a small scale (100-200 ml). Before the technology can be commercialised the team would need to further improve the regioselectivity and stability of the P450s and proof that the reactions can be scaled up in bioreactors. The technology will probably be delivered as an enzyme (amino acid sequence) with the desired properties.

There are other research groups working on a synthetic biology approach for the de novo synthesis of δ-dodecalactone from glucose by genetically engineered microbes. It is still unclear how such a process will compare in terms of product yields, economics and environmental impact with the processes proposed by the UFS patent.

If the team had to partner with a commercial company, their first choice would be to work with an established flavour and fragrance company. Another possibility would be the small French flavour and fragrance company that Dr Alizé Pennec, the post-doc and co-inventor who initially discovered the unique P450 activity, is working for.

Please view the videos for more information on patents.

The Vice-Rector: Research and Internationalisation has released two new calls for applications for funding. Academic staff and researchers are encouraged to submit applications for these funds. At this stage we are not accepting projects from Research Fellows.

The two funds are:

1. The Industrial Engagement Fund

2. The Intellectual Property Commercialisation Fund

Each fund has its own guidelines and application process. The guidelines are attached. The applications must be filled in on RIMS.

The RIMS application forms can be found through this link

For more information please click the documents below:

IP Commercialisation Fund Concept Note

The UFS Industry Engagement Fund Concept Note

News Archive

Culture contributes to success of UFS rugby teams

2015-12-15

The Sevens team of the University of the Free State followed in the footsteps of the Shimlas when the team was crowned national champion. The Kovsies Sevens team beat Tukkies April in the final of the Varsity Sevens tournament. Photo: Supplied.

The University of the Free State (UFS) Rugby Club has succeeded once again in creating a culture of values.

Marius van Rensburg, Chairman of the UFS Rugby Club, believes this was one of the reasons why Kovsies had so many rugby successes this year.

The UFS knows that money, which is more abundant at bigger universities, won't change the club into a rugby force, but "there is something special here," he said.

Van Rensburg added that the success of Shimlas, who won the Varsity Cup for the first time, also helped to build a winning culture.

Seven finals

Seven of the UFS Rugby Club's teams played in finals during 2015.

Shimlas beat the Pukke in the Varsity Cup final at Shimla Park on the Bloemfontein Campus.

The Kovsie Young Guns (against Tukkies) and Vishuis (Mopanie from Tukkies) got stuck in Bloemfontein in Varsity Cup finals.

The Shimlas won Section B of the USSA tournament in Johannesburg (against Madibaz in the final).

A strong Irawa rugby team beat Shimlas in the City Cup.

The Kovsie Sevens team was crowned as the Varsity Champions in Cape Town after beating Tukkies in the final. The team was beaten by Maties in the final of the USSA Sevens tournament in George.

Shimlas lays foundation

According to Van Rensburg, the Varsity Cup triumph by Shimlas laid a good foundation.

“After what happened in the Varsity Cup, the winning culture kind of washed over the other teams,” he said.

He also thinks the 2015 successes didn't happen overnight, but that the club managed to bring back good values. He feels that Franco Smith, the former Shimlas coach who is the Cheetahs’ current coach, also played an important part.

Greater pressure in 2016

In 2016, the UFS's rugby teams will have a greater target on their backs.

Van Rensburg agrees that there will be greater pressure, but the structures are in place.

He feels that Varsity Cup success goes together with a touch of luck, of which Shimlas had some this year.

“Looking at the draw, Shimlas will play their first two matches away against Ikeys and Tukkies. Therefore, after two matches, one might have no league points, and that would place the team under immediate pressure.”

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