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UFS busy with exciting research into flavours and fragrances

11 July 2022 | Story Andre Damons | Photo Supplied

Prof Martie Smith and Prof Drik Opperman — Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

Flavours and fragrances have a wide application in the food, feed, cosmetic, chemical and pharmaceutical sectors. Many flavour compounds are still produced via chemical synthesis or via extraction from plant or animal sources. However, there is increasing interest in their bio-production or the use of flavour compounds of (micro) biological origin.

One reason for this shift is that chemical synthesis often uses environmentally unfriendly processes. Chemical synthesis usually also produces racemic mixtures with the second enantiomer, mirror image of the looked-for compound, often having undesirable organoleptic properties. Furthermore, the consumer has developed a “chemophobia”-attitude towards synthetic chemical compounds, especially when related to food and home-care products. This applies even to nature-identical compounds – products that occur in nature but are produced via a non-natural chemical process. Products produced with the use of enzymes or microbes from “natural” substrates can be labelled “natural”. The flavour and fragrance industry thus pay higher prices for such products labelled as “natural”.

The invention

A University of the Free State (UFS) team, led by Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry are conducting exciting research in this area. They filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

The invention relates to a process for the enzymatic in-chain hydroxylation of C12 to C16 fatty acids, alcohols, and alkanes. Hydroxylation of C12 fatty acid and alcohol provides routes for the synthesis of “natural” δ-dodecalactone. The advantage of these routes is that they do not rely on massoia lactones. Massoia lactones are derived from the bark of Massoia trees which grow in Indonesia. Harvesting of the bark kills the trees.

The cytochrome P450 enzymes (P450s) claimed in this patent are to the inventors’ knowledge the most regioselective enzymes described thus far that can be used for the synthesis of δ-dodecalactone from lauric acid or 1-dodecanol. The approach that the technology takes is to claim cytochrome P450 enzymes that share 70 % amino acid identity to a set of selected P450s for the regioselective hydroxylation of lauric acid and 1-dodecanol to synthesise δ-dodecalactone.

Still in early stage

The current state of development is early stage with the technology only demonstrated in the laboratory on a small scale (100-200 ml). Before the technology can be commercialised the team would need to further improve the regioselectivity and stability of the P450s and proof that the reactions can be scaled up in bioreactors. The technology will probably be delivered as an enzyme (amino acid sequence) with the desired properties.

There are other research groups working on a synthetic biology approach for the de novo synthesis of δ-dodecalactone from glucose by genetically engineered microbes. It is still unclear how such a process will compare in terms of product yields, economics and environmental impact with the processes proposed by the UFS patent.

If the team had to partner with a commercial company, their first choice would be to work with an established flavour and fragrance company. Another possibility would be the small French flavour and fragrance company that Dr Alizé Pennec, the post-doc and co-inventor who initially discovered the unique P450 activity, is working for.

Please view the videos for more information on patents.

The Vice-Rector: Research and Internationalisation has released two new calls for applications for funding. Academic staff and researchers are encouraged to submit applications for these funds. At this stage we are not accepting projects from Research Fellows.

The two funds are:

1. The Industrial Engagement Fund

2. The Intellectual Property Commercialisation Fund

Each fund has its own guidelines and application process. The guidelines are attached. The applications must be filled in on RIMS.

The RIMS application forms can be found through this link

For more information please click the documents below:

IP Commercialisation Fund Concept Note

The UFS Industry Engagement Fund Concept Note

News Archive

A time to celebrate: Autumn graduations

2016-04-07

General graduation information
Livestreaming

The first series of graduations for the year are upon us. Graduates from all seven faculties, the Business School, and the School of Open Learning at the University of the Free State (UFS) will be celebrating their academic achievements. A total of 3681 qualifications will be conferred at ceremonies on the Bloemfontein Campus from 12 to 15 April 2016.

Sejakhumo Makhetha, daughter of our Vice-Rector: Student Affairs and External Relations, Dr Choice Makhetha, will be among the graduates receiving BA Governance and Political Transformation degrees. Coincidently, Dr Makhetha obtained her PhD in Political Science in 2003 at the UFS. Sejakhumo Makhetha is currently busy with her postgraduate diploma in the same field.

The four-day celebration symbolises the UFS prerogative as an institution to transform lives by producing leaders of tomorrow. Dr Muavia Gallie, Dr Sello Hatang, Dawie Roodt, and Nikiwe Bikitsha are expected to address these future leaders and guests at these ceremonies.

Addressed by the best

On the guest speaker line-up, we have Dr Gallie, a School and District Turnaround Strategist and education activist, who has been identified as one of the 10 Most Impressive Public Leaders for 2015 by the UFS Vice-Chancellor and Rector, Prof Jonathan Jansen. The former Head of Operations, Human Resources and Information and Communication Technology at the South African Council for Educators (SACE) has had more than 30 years of experience in education.

Dr Gallie and Dr Hatang will address graduates of the Faculties of Education, Health Sciences, Law, and Theology on 12 April 2016. Dr Hatang is the Chief Executive of the Nelson Mandela Foundation. In addition to being a founding member of the Advisory Council of the Council for the Advancement of the South African Constitution, Hatang has had the privilege of serving as the Head of Information Communications, and spokesperson for the South African Human Rights Commission as well as Director: South African History Archive at Wits University.

Dawie Roodt, founder, director, and chief economist of the Efficient Group, will speak at the Faculty of Economic and Management Science ceremony on 14 April 2016. This nationally-renowned economist boasts 30 years of experience in monetary and fiscal policy, and is one of the most referenced authors. In 2013, he published Tax, Lies and Red Tape.

As one of South Africa’s leading journalists, Nikiwe Bikitsha will draw on her 20-year career in radio, television, and journalism to address the Faculty of the Humanities graduates on the final day of graduations. Through her passion for Africa’s economic development and women empowerment, the co-founder and CEO of Amargi Media has been a successful Programme Director for UN, IMF and AU-related events.

Details of event

Dates: 12, 13, 14, 15 April 2016

Times: 09:00 and 14:30

Venue: Callie Human Centre, Bloemfontein Campus, University of the Free State

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