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UFS busy with exciting research into flavours and fragrances

11 July 2022 | Story Andre Damons | Photo Supplied

Prof Martie Smith and Prof Drik Opperman — Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

Flavours and fragrances have a wide application in the food, feed, cosmetic, chemical and pharmaceutical sectors. Many flavour compounds are still produced via chemical synthesis or via extraction from plant or animal sources. However, there is increasing interest in their bio-production or the use of flavour compounds of (micro) biological origin.

One reason for this shift is that chemical synthesis often uses environmentally unfriendly processes. Chemical synthesis usually also produces racemic mixtures with the second enantiomer, mirror image of the looked-for compound, often having undesirable organoleptic properties. Furthermore, the consumer has developed a “chemophobia”-attitude towards synthetic chemical compounds, especially when related to food and home-care products. This applies even to nature-identical compounds – products that occur in nature but are produced via a non-natural chemical process. Products produced with the use of enzymes or microbes from “natural” substrates can be labelled “natural”. The flavour and fragrance industry thus pay higher prices for such products labelled as “natural”.

The invention

A University of the Free State (UFS) team, led by Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry are conducting exciting research in this area. They filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

The invention relates to a process for the enzymatic in-chain hydroxylation of C12 to C16 fatty acids, alcohols, and alkanes. Hydroxylation of C12 fatty acid and alcohol provides routes for the synthesis of “natural” δ-dodecalactone. The advantage of these routes is that they do not rely on massoia lactones. Massoia lactones are derived from the bark of Massoia trees which grow in Indonesia. Harvesting of the bark kills the trees.

The cytochrome P450 enzymes (P450s) claimed in this patent are to the inventors’ knowledge the most regioselective enzymes described thus far that can be used for the synthesis of δ-dodecalactone from lauric acid or 1-dodecanol. The approach that the technology takes is to claim cytochrome P450 enzymes that share 70 % amino acid identity to a set of selected P450s for the regioselective hydroxylation of lauric acid and 1-dodecanol to synthesise δ-dodecalactone.

Still in early stage

The current state of development is early stage with the technology only demonstrated in the laboratory on a small scale (100-200 ml). Before the technology can be commercialised the team would need to further improve the regioselectivity and stability of the P450s and proof that the reactions can be scaled up in bioreactors. The technology will probably be delivered as an enzyme (amino acid sequence) with the desired properties.

There are other research groups working on a synthetic biology approach for the de novo synthesis of δ-dodecalactone from glucose by genetically engineered microbes. It is still unclear how such a process will compare in terms of product yields, economics and environmental impact with the processes proposed by the UFS patent.

If the team had to partner with a commercial company, their first choice would be to work with an established flavour and fragrance company. Another possibility would be the small French flavour and fragrance company that Dr Alizé Pennec, the post-doc and co-inventor who initially discovered the unique P450 activity, is working for.

Please view the videos for more information on patents.

The Vice-Rector: Research and Internationalisation has released two new calls for applications for funding. Academic staff and researchers are encouraged to submit applications for these funds. At this stage we are not accepting projects from Research Fellows.

The two funds are:

1. The Industrial Engagement Fund

2. The Intellectual Property Commercialisation Fund

Each fund has its own guidelines and application process. The guidelines are attached. The applications must be filled in on RIMS.

The RIMS application forms can be found through this link

For more information please click the documents below:

IP Commercialisation Fund Concept Note

The UFS Industry Engagement Fund Concept Note

News Archive

Research conducted on economic impact of recent international soccer and rugby matches for Bloemfontein

2004-09-09

The Centre for Development Support at the University of the Free State (UFS) recently conducted a survey on the economic impact of the international soccer and rugby games that were played in Bloemfontein earlier this year.

The research focused on the soccer match between Bafana Bafana and the Cape Verdic Isle and the rugby match between the Springboks and Ireland .

“The survey was done as a result of a research agenda about local economic development in Bloemfontein ,” said Dr Lochner Marais, researcher at the centre.

“We conducted the research by doing 402 interviews with soccer supporters and 376 interviews with rugby supporters from outside Bloemfontein ,” said Dr Marais.

The centre distributed questionnaires, collecting the following information on the soccer and rugby supporters: their age, gender and origin, the number of nights spend in Bloemfontein , their household expenditure in Bloemfontein and their rating on the quality of service.

“It is estimated that 10 800 soccer supporters and 27 000 rugby supporters came from outside Bloemfontein . Of the rugby supporters 14,4% were female and 85,6% were men. For the soccer international the percentage was 33% females and 67% males,” said Dr Marais.

The highest number of people who came to watch the soccer game in Bloemfontein (35,8%) was from the Northern Free State . The rugby supporters mainly came from Gauteng (21,8%) and the Northern Free State (18%).

When visiting Bloemfontein soccer supporters spend R912 per household, whilst rugby supporters reached deeper in their pockets and spent R1 807 per household.

“The survey indicated that the two international matches resulted in approximately R58 million been spent in Bloemfontein . Rugby supporters were accountable for the largest part (R48 787 205) spent. The largest chunk of the money spent was on accommodation (R14 593 279). On average soccer and rugby supporters from outside Bloemfontein spent 1,4 and 1,9 nights in Bloemfontein ,” said Dr Marais.

Rugby and soccer supporters were also asked to rate the quality of service received from amongst others hotels, guest houses, restaurants, and transport and entertainment facilities. Soccer supporters rated their satisfaction with services higher as rugby supporters. The rugby supporters gave the services at hotels a 3,9 rating, whilst soccer supporters awarded 4,6 rating out of a possible five.

Media release
Issued by: Lacea Loader
Media Representative
Tel: (051) 401-2584
Cell: 083 645 2454
E-mail: loaderl.stg@mail.uovs.ac.za
9 September 2004

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