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23 March 2022 | Story André Damons | Photo UFS Photo Archive
Prof Matsabisa
Prof Motlalepula Matsabisa is a professor and Director of Pharmacology at the University of the Free State (UFS)

The Department of Pharmacology at the University of the Free State (UFS) and FARMOVS have teamed up to conduct the first South African Health Products Regulatory Authority (SAHPRA)-approved multicentre controlled clinical trial of a plant-based product, PHELA, on mild to moderate COVID-19 patients.  

According to Prof Motlalepula Matsabisa, professor and Director of Pharmacology at UFS, it is anticipated that the trial will start in early April with each patient being on treatment for 28 days.

“The main purpose of the clinical trial is to confirm that the product can treat COVID-19 and be registered as a medication for this indication. We believe the medication works as an immune modulator to modulate the cytokine storm due to COVID-19 and also restores and normalises the patient’s immune system. We plan to have 250 patients who suffer from mild to moderate COVID-19,” explains Prof Matsabisa. 

This pivotal study, he says, is based on the modification of the World Health Organisation (WHO) Master protocol for clinical trials. The use of FARMOVS, a wholly owned clinical research company of the UFS Bloemfontein campus, for this clinical trial was to implement the collaborative initiatives between UFS and FARMOVS on clinical research, training, and other research projects.

What is PHELA?

Prof Matsabisa, deputy president of the South African Society for Basic and Clinical Pharmacology Society (SASBCP), says the development of PHELA has been under stringent scientific scrutiny for its safety in both preclinical and clinical research. The efficacy of PHELA as both an immune modulator and an anti-SARS-COV-2 has been proven in vitro and in vivo with reproducible results conducted by three independent research institutions and a science council.
The Department of Pharmacology and FARMOVS are collaborating on a number of studies to advance clinical research on African Traditional Medicines (ATM).

On the use of PHELA, Prof Matsabisa explains: “PHELA is a herbal product made of four medicinal plants. Traditionally PHELA has been claimed for use for a historical disease called muyaga, but recently has been scientifically tested and found effective as an immune modulator and benefiting persons with a compromised immune system.
“The PHELA plants are found in most provinces of South Africa and we have cultivated them to control their growth to produce quality raw materials.” 

“The SAHPRA-approved clinical trial will be conducted in the Eastern Cape, Northern Cape and Gauteng. The clinical trial will be conducted by a complement of medical staff and clinicians with vast experience of many active years of clinical trials.
 
“The study, we believe, is a benchmark for all future traditional medicines clinical trial protocols and studies. The studies are expected to start immediately after the product batch manufacturing of the study product, PHELA, is completed and this will be within a month’s time. “A lot of good scientific preclinical safety and efficacy research has gone into the development of the study product for it to reach this stage.

“The efficacy studies have shown convincingly that PHELA is an immune reconstitution product and does have an effect in killing the SARS-COV-2 virus and most of its variants.  PHELA efficacy, therefore, needs to be confirmed through randomised controlled multicentre clinical trials in COVID-19 patients,” Prof Matsabisa says.

Medicinal plants have previously been used to eradicate life-threatening viruses 

Although medicinal plants have been used to combat previous pandemics such as the Spanish flu, avian influenza and others, we still believe rigorous control and efficacy thereof is still to be supported by scientific research and development, says Prof Matsabisa. 

Prof Matsabisa, the current chairperson of the World Health Organisation’s (WHO) Regional Expert Advisory Committee on Traditional Medicines (REACT), adds: “We have better technologies and resources now, which is why we should take the next step in research to promote consumer safety and to offer them effective alternatives. We do the science to aid in building the herbal industry and develop sustained consumer confidence in traditional medicines. 

Africa should lead the way to a healthier future for all
“My vision is for Africa to share our valuable resources with the world by developing, and distributing world-class medicinal solutions. We should develop and strengthen the pharmaceutical local production of well-researched, quality, safe and efficacious African traditional medicines as commercial products. We are more than capable of doing so and now is the time to do it. Numerous discussions have taken place where other African countries will join South Africa in conducting multicentre studies in clinical trials for traditional medicines. 

“We need to develop or create, based on this current collaborative work with partners like FARMOVS, health centres with a strong focus on African medicines, health products and healing, but in a very strong collaborative initiative with other health systems”, concludes Prof Matsabisa.

Prof Matsabisa was recently awarded a Visiting Professorship at the Beijing University of Chinese Medicine (BUCM) in Beijing, China. He was also recommended to Naledi Pandor, Minister of International Relations and Cooperation, to be part of the India, Brazil and South Africa (IBSA) working group in traditional medicine through his participation in the national department of health technical committee on traditional medicines where he has been appointed by the Minister of Health, Dr Joe Phaahla.

News Archive

Institute for Reconciliation and Social Justice: cultivating humanity
2014-12-15

Directors of university centres focusing on Social Justice, Diversity and Transformation met at the UFS to establish the Directors' Forum. The forum discussed the state of higher education transformation in South Africa  The forum consists of (from the left) Mr Allan Zinn from the The Centre for the Advancement of Non-racialism and Democracy at the Nelson Mandela Metropolitan University, Profs Melissa Steyn from Wits University's Centre for Diversity Studies,  Andre Keet Director of the The Institute for Reconciliation and Social Justice at the University of the Free State; Rozena Maart  from The Centre for Critical Research on Race and Identity  at the University of KwaZulu Natal and Mr JC van der Merwe, researcher at the UFS Institute for Reconciliation and Social Justice
Photo: O'Ryan Heideman

The Institute for Reconciliation and Social Justice at the University of the Free State (UFS) provides a critical space that brings different voices, ideas and practices together to advance the Human and Academic Projects of the university. Students, staff and community members meet here to find ways to engage with diverse views, realities and aspirations.

“We cultivate humanity so that reconciliation and social justice can be expressed in our everyday life and we work against disrespect and inequalities on our campuses and in our society,” says Prof André Keet, Director of the Institute for Reconciliation and Social Justice.

“Through our various critical conversations, public lectures, seminars and colloquia, fresh understandings and ideas come to the fore and new inclusive ways of doing life in a local and global multicultural society are invented,” Prof Keet says. A host of international experts formed part of the institute’s events during 2014.

Dr Charles Alexander (University of California), Prof Halleh Ghorashi (Vrije Universiteit Amsterdam), Prof Alex Hinton (Rutgers University), Dr Shirley Anne Tate (University of Leeds) and Prof Susan Spearey (Brock University) were but a few of the international experts contributing to the work of the institute during the last year.

“We play key roles in transformation debates within Higher Education South Africa (HESA) and ministerial processes,” Prof Keet says. “We promote, protect and monitor human rights across our campuses and are frequently requested to support the work of the South African Human Rights Commission and to provide advice to other state agencies.”

The institute prides itself on their leading-edge research on social cohesion, reconciliation, human rights and higher education transformation. In addition, staff of the institute teaches, on invitation, at various faculties, as well as at other national and international universities.

To further bolster their impact, the institute is launching three master’s and doctoral postgraduate programmes in January 2015.

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