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23 March 2022 | Story André Damons | Photo UFS Photo Archive
Prof Matsabisa
Prof Motlalepula Matsabisa is a professor and Director of Pharmacology at the University of the Free State (UFS)

The Department of Pharmacology at the University of the Free State (UFS) and FARMOVS have teamed up to conduct the first South African Health Products Regulatory Authority (SAHPRA)-approved multicentre controlled clinical trial of a plant-based product, PHELA, on mild to moderate COVID-19 patients.  

According to Prof Motlalepula Matsabisa, professor and Director of Pharmacology at UFS, it is anticipated that the trial will start in early April with each patient being on treatment for 28 days.

“The main purpose of the clinical trial is to confirm that the product can treat COVID-19 and be registered as a medication for this indication. We believe the medication works as an immune modulator to modulate the cytokine storm due to COVID-19 and also restores and normalises the patient’s immune system. We plan to have 250 patients who suffer from mild to moderate COVID-19,” explains Prof Matsabisa. 

This pivotal study, he says, is based on the modification of the World Health Organisation (WHO) Master protocol for clinical trials. The use of FARMOVS, a wholly owned clinical research company of the UFS Bloemfontein campus, for this clinical trial was to implement the collaborative initiatives between UFS and FARMOVS on clinical research, training, and other research projects.

What is PHELA?

Prof Matsabisa, deputy president of the South African Society for Basic and Clinical Pharmacology Society (SASBCP), says the development of PHELA has been under stringent scientific scrutiny for its safety in both preclinical and clinical research. The efficacy of PHELA as both an immune modulator and an anti-SARS-COV-2 has been proven in vitro and in vivo with reproducible results conducted by three independent research institutions and a science council.
The Department of Pharmacology and FARMOVS are collaborating on a number of studies to advance clinical research on African Traditional Medicines (ATM).

On the use of PHELA, Prof Matsabisa explains: “PHELA is a herbal product made of four medicinal plants. Traditionally PHELA has been claimed for use for a historical disease called muyaga, but recently has been scientifically tested and found effective as an immune modulator and benefiting persons with a compromised immune system.
“The PHELA plants are found in most provinces of South Africa and we have cultivated them to control their growth to produce quality raw materials.” 

“The SAHPRA-approved clinical trial will be conducted in the Eastern Cape, Northern Cape and Gauteng. The clinical trial will be conducted by a complement of medical staff and clinicians with vast experience of many active years of clinical trials.
 
“The study, we believe, is a benchmark for all future traditional medicines clinical trial protocols and studies. The studies are expected to start immediately after the product batch manufacturing of the study product, PHELA, is completed and this will be within a month’s time. “A lot of good scientific preclinical safety and efficacy research has gone into the development of the study product for it to reach this stage.

“The efficacy studies have shown convincingly that PHELA is an immune reconstitution product and does have an effect in killing the SARS-COV-2 virus and most of its variants.  PHELA efficacy, therefore, needs to be confirmed through randomised controlled multicentre clinical trials in COVID-19 patients,” Prof Matsabisa says.

Medicinal plants have previously been used to eradicate life-threatening viruses 

Although medicinal plants have been used to combat previous pandemics such as the Spanish flu, avian influenza and others, we still believe rigorous control and efficacy thereof is still to be supported by scientific research and development, says Prof Matsabisa. 

Prof Matsabisa, the current chairperson of the World Health Organisation’s (WHO) Regional Expert Advisory Committee on Traditional Medicines (REACT), adds: “We have better technologies and resources now, which is why we should take the next step in research to promote consumer safety and to offer them effective alternatives. We do the science to aid in building the herbal industry and develop sustained consumer confidence in traditional medicines. 

Africa should lead the way to a healthier future for all
“My vision is for Africa to share our valuable resources with the world by developing, and distributing world-class medicinal solutions. We should develop and strengthen the pharmaceutical local production of well-researched, quality, safe and efficacious African traditional medicines as commercial products. We are more than capable of doing so and now is the time to do it. Numerous discussions have taken place where other African countries will join South Africa in conducting multicentre studies in clinical trials for traditional medicines. 

“We need to develop or create, based on this current collaborative work with partners like FARMOVS, health centres with a strong focus on African medicines, health products and healing, but in a very strong collaborative initiative with other health systems”, concludes Prof Matsabisa.

Prof Matsabisa was recently awarded a Visiting Professorship at the Beijing University of Chinese Medicine (BUCM) in Beijing, China. He was also recommended to Naledi Pandor, Minister of International Relations and Cooperation, to be part of the India, Brazil and South Africa (IBSA) working group in traditional medicine through his participation in the national department of health technical committee on traditional medicines where he has been appointed by the Minister of Health, Dr Joe Phaahla.

News Archive

Brazil: Wayde’s dream destination since childhood
2015-12-15


Wayde van Niekerk knows he has to work even harder in 2016 if he wants to achieve success at the Olympic Games in Rio de Janeiro. Photo: Charl Devenish

When he was still in primary school, Wayde’s dream destination was Brazil. Even his dog’s name is Rio.

So it almost seems written in the stars for Wayde van Niekerk to take part in the 2016 Olympic Games in Rio de Janerio.

According to the 400m athlete of the University of the Free State (UFS), the Olympics has been something he has been dreaming about for years.

Van Niekerk, who studies BA Marketing at the UFS, has had a phenomenal 2015 season, and the whole of South Africa hopes he can repeat his outstanding form in Rio. The Olympics will be held from 5-21 August 2016.

Funny story

“It actually is a funny story. You know when you are in primary school, and the teacher says you have to write down your dream destination. Mine was Brazil,” Van Niekerk revealed.

“In 2012 at the closing ceremony of the London Olympics, I saw they introduced Rio as the next hosting country, and I thought Wow! That is where I want to be, and what I want to do.

“That opened my eyes and I knew God has a plan for me. I have to put in the hard work and achieve something with my life. Luckily from there on, there was pure growth in my life and I am grateful for that.”

His dream is also carried by his dog, Rio, a husky he got about two years ago.

Preparation in 2016

Van Niekerk will follow a specific programme leading up to Rio 2016.

In February next year, he will still be taking things easy, but will probably compete for the UFS in the Varsity Sports athletics.

“You have to build up slowly to peak at the right time,” he said.

In June 2016, he will start competing internationally in Jamaica, then New York, the All-Africa Games in Durban, and then,  some Diamond League events before the Olympics in August.

In the archive:

KovsieSport star

NBC tells waydes story

Wayde nominated as SAs best

Wayde Adidas face

Wayde’s hat trick of awards

Congratulate wayde and other achievers

Wayde wins gold

Kovsie trailblazing track runner

Kovsie gold medalist

Kovsie Campion sprinter

Wayde sets African record

Kovsies keep winning, this time in athletics

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