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23 March 2022 | Story André Damons | Photo UFS Photo Archive
Prof Matsabisa
Prof Motlalepula Matsabisa is a professor and Director of Pharmacology at the University of the Free State (UFS)

The Department of Pharmacology at the University of the Free State (UFS) and FARMOVS have teamed up to conduct the first South African Health Products Regulatory Authority (SAHPRA)-approved multicentre controlled clinical trial of a plant-based product, PHELA, on mild to moderate COVID-19 patients.  

According to Prof Motlalepula Matsabisa, professor and Director of Pharmacology at UFS, it is anticipated that the trial will start in early April with each patient being on treatment for 28 days.

“The main purpose of the clinical trial is to confirm that the product can treat COVID-19 and be registered as a medication for this indication. We believe the medication works as an immune modulator to modulate the cytokine storm due to COVID-19 and also restores and normalises the patient’s immune system. We plan to have 250 patients who suffer from mild to moderate COVID-19,” explains Prof Matsabisa. 

This pivotal study, he says, is based on the modification of the World Health Organisation (WHO) Master protocol for clinical trials. The use of FARMOVS, a wholly owned clinical research company of the UFS Bloemfontein campus, for this clinical trial was to implement the collaborative initiatives between UFS and FARMOVS on clinical research, training, and other research projects.

What is PHELA?

Prof Matsabisa, deputy president of the South African Society for Basic and Clinical Pharmacology Society (SASBCP), says the development of PHELA has been under stringent scientific scrutiny for its safety in both preclinical and clinical research. The efficacy of PHELA as both an immune modulator and an anti-SARS-COV-2 has been proven in vitro and in vivo with reproducible results conducted by three independent research institutions and a science council.
The Department of Pharmacology and FARMOVS are collaborating on a number of studies to advance clinical research on African Traditional Medicines (ATM).

On the use of PHELA, Prof Matsabisa explains: “PHELA is a herbal product made of four medicinal plants. Traditionally PHELA has been claimed for use for a historical disease called muyaga, but recently has been scientifically tested and found effective as an immune modulator and benefiting persons with a compromised immune system.
“The PHELA plants are found in most provinces of South Africa and we have cultivated them to control their growth to produce quality raw materials.” 

“The SAHPRA-approved clinical trial will be conducted in the Eastern Cape, Northern Cape and Gauteng. The clinical trial will be conducted by a complement of medical staff and clinicians with vast experience of many active years of clinical trials.
 
“The study, we believe, is a benchmark for all future traditional medicines clinical trial protocols and studies. The studies are expected to start immediately after the product batch manufacturing of the study product, PHELA, is completed and this will be within a month’s time. “A lot of good scientific preclinical safety and efficacy research has gone into the development of the study product for it to reach this stage.

“The efficacy studies have shown convincingly that PHELA is an immune reconstitution product and does have an effect in killing the SARS-COV-2 virus and most of its variants.  PHELA efficacy, therefore, needs to be confirmed through randomised controlled multicentre clinical trials in COVID-19 patients,” Prof Matsabisa says.

Medicinal plants have previously been used to eradicate life-threatening viruses 

Although medicinal plants have been used to combat previous pandemics such as the Spanish flu, avian influenza and others, we still believe rigorous control and efficacy thereof is still to be supported by scientific research and development, says Prof Matsabisa. 

Prof Matsabisa, the current chairperson of the World Health Organisation’s (WHO) Regional Expert Advisory Committee on Traditional Medicines (REACT), adds: “We have better technologies and resources now, which is why we should take the next step in research to promote consumer safety and to offer them effective alternatives. We do the science to aid in building the herbal industry and develop sustained consumer confidence in traditional medicines. 

Africa should lead the way to a healthier future for all
“My vision is for Africa to share our valuable resources with the world by developing, and distributing world-class medicinal solutions. We should develop and strengthen the pharmaceutical local production of well-researched, quality, safe and efficacious African traditional medicines as commercial products. We are more than capable of doing so and now is the time to do it. Numerous discussions have taken place where other African countries will join South Africa in conducting multicentre studies in clinical trials for traditional medicines. 

“We need to develop or create, based on this current collaborative work with partners like FARMOVS, health centres with a strong focus on African medicines, health products and healing, but in a very strong collaborative initiative with other health systems”, concludes Prof Matsabisa.

Prof Matsabisa was recently awarded a Visiting Professorship at the Beijing University of Chinese Medicine (BUCM) in Beijing, China. He was also recommended to Naledi Pandor, Minister of International Relations and Cooperation, to be part of the India, Brazil and South Africa (IBSA) working group in traditional medicine through his participation in the national department of health technical committee on traditional medicines where he has been appointed by the Minister of Health, Dr Joe Phaahla.

News Archive

UFS Dean scoops prestigious award for analysis of book of Malachi
2017-05-15

Description: Prof Fanie Snyman book Tags: Prof Fanie Snyman book

Willem Louw, Chairperson of the UFS Council;
Dr Khotso Mokhele , Chancellor of the UFS,
Eleanor van der Westhuizen, from the Directorate
of Research Development; Prof Francis Petersen,
UFS Vice-Chancellor and Rector; Prof Fanie Snyman,
Dean of the Faculty of Theology; and
Prof Corli Witthuhn, Vice-Rector: Research.
Photo: Johan Roux

The most sought-after award at the UFS, the annual Book Prize for Distinguished Scholarship, was recently won by Prof Fanie Snyman, Dean of the Faculty of Theology and Religion. His book, Malachi, which is about the last book of the Old Testament, has received acknowledgement through this award. He is the third academic to be awarded this prize. The book was published in English by Peeters Publishers in Belgium as part of the ”Historical Commentary on the Old Testament” series with a view to an international audience, and can be used by theology scholars and academics.

Labour of love over many years
Prof Snyman has a long history with the Bible book of Malachi. Since his student years, this book in the so-called ‘Minor Prophets’ of the Old Testament had a special charm for him. In fact, Prof Snyman has produced several publications on this concise book of 55 verses over the years. Furthermore, his doctoral thesis, as well as several papers delivered at congresses, also had this book as the theme. It took Prof Snyman about a decade to write the book.

What lies ahead for him in the future? “I am closing the book Malachi for the time being,” says Prof Snyman. “However, my research on the ‘Minor Prophets’ will continue. As a result of Malachi, InterVarsity Press in Cambridge contacted me for the writing of a book in another international commentary series, this time on the books Nahum, Habakkuk, and Zephaniah.” Prof Snyman will use his prize money of R75 000 towards this goal.

Book prize a surprise
“I can sincerely say that I did not expect the award at all. I did not know which other excellent research was submitted and thought that research from another discipline might do better. Therefore, I was completely surprised when my book was announced as the winner, and it left me speechless at the moment!” says a modest Prof Snyman.

He adds: “I am sincerely grateful for this award, but I must also thank the university. I would like to express my appreciation for the academic milieu, financial support, as well as overseas travel opportunities that have enabled me to complete the book and achieve this award.”
 
Book review by international expert
Prof Rainer Kessler, a world-renowned expert on the Bible book of Malachi, said in a review of Malachi: “The commentary on Malachi in the renowned Historical Commentary on the Old Testament series is the fruit of decades of studies on the book. [It] is full of respect towards the text. [Prof] Snyman is very cautious in his judgements and decisions. He rather presents different possibilities than uttering one-sided positions. [Finally, he] treats others always in a very fair manner. He presents their opinions as objectively as possible, especially when he does not agree. This commentary is a new and very useful tool for the study on the often underestimated last book of the Old Testament prophets.”

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