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22 March 2022 | Story André Damons
Dr Yolandi Swart
Dr Yolandi Swart, who took over from Prof Lynette van der Merwe as the new Director of the Undergraduate Medical Programme (MB ChB programme) in the School of Clinical Medicine within the Faculty of Health Sciences at the University of the Free State (UFS), says she is excited about the new opportunities that come with this position.

The new Director of the Undergraduate Medical Programme (MB ChB programme) in the School of Clinical Medicine within the Faculty of Health Sciences at the University of the Free State (UFS) has a passion for teaching and learning and brings a wealth of experience with her.

Dr Yolandi Swart, who took over from Prof Lynette van der Merwe on 1 March 2022, says she is excited about the new opportunities that this position brings. She was not actively job-hunting and came across the advertisement by accident but was thrilled when she was informed that she is the recommended candidate.

A deep love for the UFS

“I will be heading up an amazing team of people who drive the MB ChB programme, making sure that we walk with our students on their journey to become the next generation of health professionals who will contribute to the health and wellness of our population. Our functions include coordinating the undergraduate curriculum, providing student support, as well as logistic support to ensure the smooth running of the MB ChB programme,” says Dr Swart.

As an alumna of the university (she obtained both her MB ChB and postgraduate MMed in Community Health at the UFS), she has a deep love for the UFS, as it has played a huge role in developing her into the person she is today.

According to Dr Swart, she looks forward to getting to know the students and seeing them develop into the best they can be, as well as engaging with the academic staff as they guide and train the students. She brings a diverse background to the position, having practised as a doctor, specialised in Community Health, and worked in clinical research at various levels, including senior management. This has afforded her the opportunity to equip herself with skills that she hopes will provide support and direction to the Undergraduate Programme Management team in order to provide excellent service in all its functions.

Her vision

“I love teaching and learning – taking a concept and making it accessible to someone.  There are few things as satisfying as seeing that expression that says ‘Oh, now I get it!’

Kovsies has always had a reputation of producing excellent doctors.  “It is my vision to build on that reputation, integrating local and international best practices as they develop into our students’ training, with the aim of developing young professionals who are competent, resilient, and able to face the challenges that life will throw at them – so that they, in turn, can play their role to influence lives for the better.”

Prior to her appointment, she worked at FARMOVS as a clinical research physician for more than six years, the past year and a half as the company’s Medical Director. Says Dr Swart: “I love challenging myself with new things every so often. Past and present hobbies include surfing (which died an early death, as I was horrible at it), scuba diving (yes, with sharks as well), horse-riding, and self-defence.  Most recently, I got hooked on traditional archery – a very challenging skill to try and master.”

Dr Swart says she has learned throughout her personal life and professional career that life sometimes takes unexpected turns – but if one is open to the opportunities afforded by those unexpected turns, it often turns out so much better than the original plan could ever have been. “Difficulties and challenges will always come – but if one faces them with a positive attitude, they teach life skills that you would otherwise never have attained.”

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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