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18 May 2022 | Story Rulanzen Martin | Photo Supplied
Jon Kehrer
Jon Kehrer is a prolific academic and scholar. He also spent a few years teaching English in the Middle East.

It was a former professor who influenced American scholar Jon Kehrer to further his academic journey with the Department of Hebrew at the University of the Free State (UFS). And it was at the UFS where he recently graduated cum laude with a master’s degree in Hebrew, and was named recipient of the Dean’s Medal. 

Although he never expected to receive the Dean’s Medal, he is very glad – and somewhat relieved – that his dissertation made it through the examiners. “I never anticipated receiving this award. It makes me even more grateful for the strong Hebrew Department at UFS, and their rigorous standards for their students,” Kehrer says. 

“I wish I had been able to attend the graduation ceremony, but the circumstances of the semester just did not allow it.” Kehrer is currently teaching in the areas of the Old Testament and Biblical Languages at the Ozark Christian College (OCC) in Missouri, USA. In addition to his UFS qualifications Kehrer also holds a Bachelor of Theology qualification from the OCC. “I love the opportunity to invest in students and help them see new perspectives,” he says. 

UFS Hebrew a firm foundation for a solid academic career  

“I was looking for a high-quality and challenging programme that was flexible, especially since I work full-time and have a large family,” Kehrer says, as he recalls how he initially decided to become part of the UFS. He remembers fondly how Dr Kevin Chau, senior lecturer in Hebrew at the UFS, motivated and supported him when he first enrolled for the BA Honours programme. 

It is also a testament that the Department of Hebrew has made an impact internationally for the quality of its academic offerings. “Dr Chau helped me to think about how what I was learning would have an impact on my research and teaching in the future, and he was always quick to provide thorough and constructive feedback on my work,” Kehrer says.  

Once enrolled for the master’s programme it was initially difficult to know which direction to pursue and what topic to research, but the guidance and support of his two advisors, Prof Cynthia Miller-Naude and Prof Jacobus Naude, was “very helpful”.

“They never dictated what paths I should pursue, but they listened carefully and provided expert guidance to help me choose the path that would best suit my interests and the needs of the field,” he says. 

It was this support from the Department of Hebrew and its excellent reputation that came full circle when Kehrer was named Dean’s Medal recipient for achieving the highest marks of any student in a master’s qualification in the UFS Faculty of The Humanities. 

Dissertation a closer look at verbs in Biblical Hebrew 

His dissertation focused on Biblical Hebrew and how the object of a verb appears in various ways. “Sometimes an object appears by itself, but sometimes it can have a preposition or a two-consonant Biblical Hebrew particle along with it. Many Bible translations treat all these objects the same,” he says. “I wanted to try to understand why these variations occurred, so I looked at how different sentence elements might contribute to the variation. It was a fascinating study!” 
 
Kehrer believes it is important for university students to continue studying classical subjects like Hebrew. “I think we can all learn much from those who have gone before us, and so much wisdom and insight is connected to these ancient Biblical Hebrew texts, texts that would be inaccessible to us without translation,” he says. 

“I also think classical disciplines can help train students to think well and to read critically – essential skills for living in today’s ever-changing world.”  

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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