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09 May 2022 | Story Leonie Bolleurs | Photo Stephen Collett
Prof Linus Franke delivered his inaugural lecture on the topic Contested Science for Sustainable Agriculture.

Conducting research on weed control for India at the Scottish Agricultural College in Scotland, studying soybean at the International Institute of Tropical Agriculture in Nigeria, and working with genetically modified crops at Agrosystems Research, Dienst Landbouwkundig Onderzoek (DLO) in Wageningen in the Netherlands, grain legumes in sub-Saharan Africa, and potatoes in South Africa. 

These are some of the agricultural practices that Prof Linus Franke, Academic Head of the Department of Soil, Crop and Climate Sciences at the University of the Free State (UFS), has seen and experienced in several countries, which contributed to his extensive knowledge on this matter.

More specifically, sustainable agriculture is his passion and the focus of his life’s work. In celebration of his academic career, this was also the topic of his inaugural lecture: Contested Science for Sustainable Agriculture, delivered on the Bloemfontein Campus on 4 May 2022.

With years of experience in the field, he reflected on sustainable agriculture, firstly stating that it would be good if we could have discussions on sustainable agriculture and the future of agriculture based on empirical evidence. “However, the reality is that ideology and a strong involvement of non-specialists is unavoidable,” he says.

Secondly, he adds, it would be a major improvement if we could move away from embracing universal principles for farming practices and forcing them into a local context. “It would be better if local contexts and aspirations could guide the way in which general production principles are applied.” Adding to that, he states the importance of measurements. “If you want to embrace the concept of sustainability, you must be able to measure it.” 

Solutions to environmental problems 

In his lecture, he took the audience back to years ago when he was doing his master’s research on organic farming systems, excited about organic agriculture as an approach that holds the promise of tackling major environmental problems in a radical manner. This bout of excitement about the prospects of organic agriculture was, however, short-lived. Fed up with the “dogmatic and anti-science attitude and the tribalism in the sector”, he saw his flirt with organic agriculture as youthful foolishness.

After spending years in India and Nigeria, Prof Franke produced reports on the sustainability and trade impacts of genetically modified crops. People in the organic and green movement, however, have expressed opposed views. “In their eyes, I was one of those short-sighted scientists unable to recognise the dangers of genetically modified (GM) crops.”
Investments in regenerative agriculture have become a means to reduce the pressure to invest in curbing greenhouse gas emissions from fossil fuel use elsewhere. – Prof Linus Franke

This made him wonder what drives these polarised discussions on GM crops and sustainable agriculture in general. “I learned that the strong and almost irrational position that the green movement has taken against GM crops and in favour of organic agriculture is merely a reflection of underlying emotions and preferences,” he says.

He explains two different lines of thinking about how to deal with the ecological challenges associated with agriculture, namely looking at nature to find solutions to environmental problems associated with agriculture, versus the idea that technology will come to our rescue. “The ecological problems we face in relation to agriculture are caused by modern farming technologies. Genetic modification is seen as an extension of the technologies that were responsible for the problems in the first place. To solve the problem, we need to look back at nature, learn from nature, and apply ecological principles to farming. You could argue that this view is rather unscientific and techno phobic. But believing that new technologies will come to recue us in the looming ecological crisis is equally based on a gut feeling, there are no guarantees that this will happen.”

Regenerative agriculture

Despite the strong position taken by the green movement in favour of organic agriculture, the organic movement became stagnant. “In Europe it represents only 5% of the total agricultural production and in South Africa it never really took off. GM crops have been relatively easily accepted here.”

GM crops and organic agriculture may not be major issues in South Africa, but regenerative agriculture has become a big topic and the discussion and dynamics around regenerative agriculture resemble those around organic agriculture.

Prof Linus Franke delivered his inaugural lecture on the topic Contested Science for Sustainable Agriculture. (Photo: Stephen Collett) 

"Over time, new approaches to agriculture have emerged, promising radical improvements in sustainability. Including conservation agriculture, holistic grazing, permaculture, and agro-forestry, these new approaches are grouped under the flag of regenerative farming and are attracting much attention. This has stimulated interest in using knowledge of ecological processes to improve agricultural production. 

“This is truly positive,” states Prof Franke. “It is great to see farmers in South Africa coming together and thinking about ways to apply some of these principles in their farming practices.”

Many of these approaches have proven their merits, but only under certain conditions. “Although many see regenerative farming approaches as globally applicable solutions to the big ecological challenges of today, it is important to take note of the context and the empirical evidence of the claimed benefits. Inspiration by nature does not necessarily lead to farming practices that are ecologically superior,” he says. 

Conservation agriculture, for instance, worked on large-scale mechanised crop farms in Australia and the Americas and it gained a firm foothold in the Western Cape. “But in Africa, including South Africa, conservation agriculture is widely promoted among smallholders, often with disappointing results,” he says.

Another challenge he addressed during his lecture, was that of expectations of regenerative agriculture being way beyond what farmers actually achieve. He found that large food corporations had announced major investments in regenerative agriculture, and by doing so, hoped to reduce their carbon footprint regarding production activities. The big issue here is that it is highly uncertain and questionable whether these improvements in carbon sequestration can be achieved. Prof Franke believes that for some companies, investments in regenerative agriculture have become a means to reduce the pressure to invest in curbing greenhouse gas emissions from fossil fuel use elsewhere.

Watch recording of the Inaugural Lecture below:




News Archive

Cardiology Unit involved in evaluation of drug for rare genetic disease
2013-01-04

Front from the left, are: Marinda Karsten (study coordinator and registered nurse),
Laumarie de Wet (clinical technologist), Charmaine Krahenbuhl (study coordinator and radiographer),
Lorinda de Meyer (administrator), Andonia Page (study coordinator and enrolled nurse);
back Dr Gideon Visagie (sub investigator), Dr Derick Aucamp (sub investigagtor),
Prof. Hennie Theron, (principal investigator) and Dr Wilhelm Herbst (sub investigator).
Photo: Supplied
09 January 2013


The Cardiology Research Unit at the University of the Free State (UFS) contributed largely to the evaluation of the drug Juxtapid (lomitapide), which was developed by the Aegerion pharmaceutical company and approved by the FDA (Federal Drug Administration). Together with countries such as die USA, Canada and Italy, the UFS’ Unit recruited and evaluated the most patients (5 of 29) for the study since 2008.  

The drug was evaluated in persons with so-called familial homozygous hypercholesterolemia (HoFH).  

Following its approval by the FDA, Juxtapid is now a new treatment option for patients suffering from HoFH. The drug operates in a unique way which brings about dramatic improvements in cholesterol counts.  

According to Prof. Hennie Theron, Associate Professor in the Department of Cardiology at the UFS and Head of the Cardiology Contract Research Unit, HoFH is a serious, rare genetic disease which affects the function of the receptor responsible for the removal of low-density lipoprotein cholesterol (LDL-C) (“bad” cholesterol) from the body. Damage to the LDL receptor function leads to extremely high levels of blood cholesterol. HoFH patients often develop premature and progressive atherosclerosis, which is a narrowing or blockage of the arteries.  

“HoFH is a genetically transmitted disease and the most severe form of hypercholesterolemia. Patients often need a coronary artery bypass or/and aortic valve replacement before the age of 20. Mortality is extremely high and death often occurs before the third decade of life. Existing conventional cholesterol-lowering medication is unsuccessful in achieving normal target cholesterol values in this group of patients.  

“The only modality for treatment is plasmapheresis (similar to dialysis in patients with renal failure). Even with this type of therapy the results are relatively unsatisfactory because it is very expensive and the plasmapheresis has to be performed on a regular basis.  

“The drug Juxtapid, as currently evaluated, has led to a dramatic reduction in cholesterol values and normal values were achieved in several people. No existing drug is nearly as effective.  

“The drug represents a breakthrough in the treatment of familial homozygous hypercholesterolemia. The fact that it has been approved by the FDA, gives further impetus to the findings,” says Prof. Theron.  

In future further evaluation will be performed in other forms of hypocholesterolemia.  

According to Prof. Theron, the findings of the study, as well as the recent successful FDA evaluation, once again confirms the fact that the UFS’ Cardiology Contract Research Unit is doing outstanding work.  

Since its inception in 1992, the Unit has already been involved in more than 60 multi-centre, international phase 2 and 3 drug studies. Several of these studies, including the abovementioned study, really affected the way in which cardiology functions.  

The UFS’ Cardiology Contract Research Unit is being recognised nationally and internationally for its high quality of work and is constantly approached for their involvement in new studies.  

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