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09 May 2022 | Story Leonie Bolleurs | Photo Stephen Collett
Prof Linus Franke delivered his inaugural lecture on the topic Contested Science for Sustainable Agriculture.

Conducting research on weed control for India at the Scottish Agricultural College in Scotland, studying soybean at the International Institute of Tropical Agriculture in Nigeria, and working with genetically modified crops at Agrosystems Research, Dienst Landbouwkundig Onderzoek (DLO) in Wageningen in the Netherlands, grain legumes in sub-Saharan Africa, and potatoes in South Africa. 

These are some of the agricultural practices that Prof Linus Franke, Academic Head of the Department of Soil, Crop and Climate Sciences at the University of the Free State (UFS), has seen and experienced in several countries, which contributed to his extensive knowledge on this matter.

More specifically, sustainable agriculture is his passion and the focus of his life’s work. In celebration of his academic career, this was also the topic of his inaugural lecture: Contested Science for Sustainable Agriculture, delivered on the Bloemfontein Campus on 4 May 2022.

With years of experience in the field, he reflected on sustainable agriculture, firstly stating that it would be good if we could have discussions on sustainable agriculture and the future of agriculture based on empirical evidence. “However, the reality is that ideology and a strong involvement of non-specialists is unavoidable,” he says.

Secondly, he adds, it would be a major improvement if we could move away from embracing universal principles for farming practices and forcing them into a local context. “It would be better if local contexts and aspirations could guide the way in which general production principles are applied.” Adding to that, he states the importance of measurements. “If you want to embrace the concept of sustainability, you must be able to measure it.” 

Solutions to environmental problems 

In his lecture, he took the audience back to years ago when he was doing his master’s research on organic farming systems, excited about organic agriculture as an approach that holds the promise of tackling major environmental problems in a radical manner. This bout of excitement about the prospects of organic agriculture was, however, short-lived. Fed up with the “dogmatic and anti-science attitude and the tribalism in the sector”, he saw his flirt with organic agriculture as youthful foolishness.

After spending years in India and Nigeria, Prof Franke produced reports on the sustainability and trade impacts of genetically modified crops. People in the organic and green movement, however, have expressed opposed views. “In their eyes, I was one of those short-sighted scientists unable to recognise the dangers of genetically modified (GM) crops.”
Investments in regenerative agriculture have become a means to reduce the pressure to invest in curbing greenhouse gas emissions from fossil fuel use elsewhere. – Prof Linus Franke

This made him wonder what drives these polarised discussions on GM crops and sustainable agriculture in general. “I learned that the strong and almost irrational position that the green movement has taken against GM crops and in favour of organic agriculture is merely a reflection of underlying emotions and preferences,” he says.

He explains two different lines of thinking about how to deal with the ecological challenges associated with agriculture, namely looking at nature to find solutions to environmental problems associated with agriculture, versus the idea that technology will come to our rescue. “The ecological problems we face in relation to agriculture are caused by modern farming technologies. Genetic modification is seen as an extension of the technologies that were responsible for the problems in the first place. To solve the problem, we need to look back at nature, learn from nature, and apply ecological principles to farming. You could argue that this view is rather unscientific and techno phobic. But believing that new technologies will come to recue us in the looming ecological crisis is equally based on a gut feeling, there are no guarantees that this will happen.”

Regenerative agriculture

Despite the strong position taken by the green movement in favour of organic agriculture, the organic movement became stagnant. “In Europe it represents only 5% of the total agricultural production and in South Africa it never really took off. GM crops have been relatively easily accepted here.”

GM crops and organic agriculture may not be major issues in South Africa, but regenerative agriculture has become a big topic and the discussion and dynamics around regenerative agriculture resemble those around organic agriculture.

Prof Linus Franke delivered his inaugural lecture on the topic Contested Science for Sustainable Agriculture. (Photo: Stephen Collett) 

"Over time, new approaches to agriculture have emerged, promising radical improvements in sustainability. Including conservation agriculture, holistic grazing, permaculture, and agro-forestry, these new approaches are grouped under the flag of regenerative farming and are attracting much attention. This has stimulated interest in using knowledge of ecological processes to improve agricultural production. 

“This is truly positive,” states Prof Franke. “It is great to see farmers in South Africa coming together and thinking about ways to apply some of these principles in their farming practices.”

Many of these approaches have proven their merits, but only under certain conditions. “Although many see regenerative farming approaches as globally applicable solutions to the big ecological challenges of today, it is important to take note of the context and the empirical evidence of the claimed benefits. Inspiration by nature does not necessarily lead to farming practices that are ecologically superior,” he says. 

Conservation agriculture, for instance, worked on large-scale mechanised crop farms in Australia and the Americas and it gained a firm foothold in the Western Cape. “But in Africa, including South Africa, conservation agriculture is widely promoted among smallholders, often with disappointing results,” he says.

Another challenge he addressed during his lecture, was that of expectations of regenerative agriculture being way beyond what farmers actually achieve. He found that large food corporations had announced major investments in regenerative agriculture, and by doing so, hoped to reduce their carbon footprint regarding production activities. The big issue here is that it is highly uncertain and questionable whether these improvements in carbon sequestration can be achieved. Prof Franke believes that for some companies, investments in regenerative agriculture have become a means to reduce the pressure to invest in curbing greenhouse gas emissions from fossil fuel use elsewhere.

Watch recording of the Inaugural Lecture below:




News Archive

Research contributes to improving quality of life for cancer patients
2016-11-21

Description: Inorganic Chemistry supervisors  Tags: Inorganic Chemistry supervisors

Inorganic Chemistry supervisors in the Radiopharmacy
Laboratory during the preparation of a typical complex
mixture to see how fast it reacts. Here are, from the left,
front: Dr Marietjie Schutte-Smith, Dr Alice Brink
(both scholars from the UFS Prestige
Scholar Programme), and Dr Truidie Venter (all three
are Thuthuka-funded researchers).
Back: Prof André Roodt and Dr Johan Venter.
Photo: Supplied

Imagine that you have been diagnosed with bone cancer and only have six months to live. You are in a wheelchair because the pain in your legs is so immense that you can’t walk anymore – similar to a mechanism eating your bones from the inside.

You are lucky though, since you could be injected with a drug to control the pain so effective that you will be able to get out of the wheelchair within a day-and-a-half and be able to walk again. Real-life incidents like these provide intense job satisfaction to Prof André Roodt, Head of Inorganic Chemistry at the University of the Free State (UFS). The research, which is conducted by the Inorganic Group at the UFS, contributes greatly to the availability of pain therapy that does not involve drugs, but improves the quality of life for cancer patients.

The research conducted by the Inorganic Group under the leadership of Prof Roodt, plays a major role in the clever design of model medicines to better detect and treat cancer.

The Department of Chemistry is one of approximately 10 institutions worldwide that conducts research on chemical mechanisms to identify and control cancer. “The fact that we are able to cooperate with the Departments of Nuclear Medicine and Medical Physics at the UFS, the Animal Research Centre, and other collaborators in South Africa and abroad, but especially the methodology we utilise to conduct research (studying the chemical manner in which drugs are absorbed in cancer as well as the time involved), enhances the possibility of making a contribution to cancer research,” says Prof Roodt.

Technique to detect cancer spots on bone
According to the professor, there are various ways of detecting cancer in the body. Cancer can, inter alia, be identified by analysing blood, X-rays (external) or through an internal technique where the patient is injected with a radioactive isotope.

Prof Roodt explains: “The doctor suspects that the patient has bone cancer and injects the person with a drug consisting of an isotope (only emits X-rays and does no damage to tissue) that is connected to a phosphonate (similar to those used for osteoporosis). Once the drug is injected, the isotope (Technetium-99m) moves to the spot on the bone where the cancer is located. The gamma rays in the isotope illuminate the area and the doctor can see exactly where treatment should be applied. The Technetium-99m has the same intensity gamma rays as normal X-rays and therefore operates the same as an internal X-ray supply.” With this technique, the doctor can see where the cancer spots are within a few hours.

The same technique can be used to identify inactive parts of the brain in Alzheimer patients, as well as areas of the heart where there is no blood supply or where the heart muscle is dead.

Therapeutic irradiation of cancer
For the treatment of pain connected with cancer, the isotope Rhenium-186 is injected. Similar to the manner in which the Technetium-99m phosphonate compound is ingested into the body, the Rhenium-186 phosphonate travels to the cancer spots. Patients thus receive therapeutic irradiation – a technique known as palliative therapy, which is excellent for treating pain. A dosage of this therapy usually lasts for about two months.

The therapy is, however, patient specific. The dosages should correspond with the occurrence and size of cancer spots in the patient’s body. First, the location of the cancer will be determined by means of a technetium scan. After that, the size of the area where the cancer occurs has to be determined. The dosage for addressing total pain distribution will be calculated according to these results.

Technique to detect cancer spots on soft tissue
Another technique to detect cancer as spots on bone or in soft tissue and organs throughout the body is by utilising a different type of irradiation, a so-called PET isotope. The Fluor-18 isotope is currently used widely, and in Pretoria a machine called a cyclotron was produced by Dr Gerdus Kemp, who is a former PhD graduate from the Inorganic Research Group. The F-18 is then hidden within a glucose molecule and a patient will be injected with the drug after being tranquillised and after the metabolism has been lowered considerably. The glucose, which is the ‘food' that cancer needs to grow, will then travel directly to the cancer area and the specific area where the cancer is located will thus be traced and ‘illuminated’ by the Fluor-18, which emits its own 'X-rays'.

In the late 80s, Prof Roodt did his own postdoctoral study on this research in the US. He started collaborating with the Department of Nuclear Medicine at the UFS in the early 90s, when he initiated testing for this research.

Through their research of more than 15 years, the Inorganic Group in the Department of Chemistry has made a major contribution to cancer research. Research on mechanisms for the detection of cancer, by designing new clever chemical agents, and the chemical ways in which these agents are taken up in the body, especially contributes to the development in terms of cancer therapy and imaging, and has been used by a number of hospitals in South Africa.

The future holds great promise
Prof Roodt and his team are already working on a bilateral study between the UFS and Kenya. It involves the linking of radio isotopes, as mentioned above, to known natural products (such as rooibos tea), which possess anti-cancer qualities.

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