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31 May 2022 | Story Lunga Luthuli | Photo Supplied
Melissa De Aveiro

Singer, writer, and motivational speaker, Melissa de Aveiro, says: “One can only rise from the ashes when the fire starts again, and the beauty of it all is that the ashes is stuck to your clothes. As you move on, you build off it as it falls from your clothes.”

She said: “When the fire starts in you, nothing is going to stop it.”

This she said at the Division of Organisational Development and Employee Well-being’s Rising from the Ashes event held at the Centenary Complex on the Bloemfontein Campus. Melissa’s story is about never giving up and “never backing down – even when people throw you with rocks, use the rocks to build a new road”.

Melissa said: “Many people unfortunately do not rise from the ashes because there is no support from friends, people. You can never do it alone as the journey through the ashes is lonely.”

Melissa believes to get through the ashes, one has to go back and “remind yourself of when it was good in your life, remind yourself about the positive things – even though things might not be great now”.

Known as the 'Weskus Dutchess', and growing up in Vredendal, Western Cape, Melissa’s tough life, sexual abuse, drug abuse, homelessness, and the death of her son never stopped her from dreaming. All the setbacks planted in her a “passion for a guitar and people, a birth of a new season, a desire to change the world”.

To rise from the ashes, Melissa said, “You need to go back to the place where you were hurting, confront the demons, the people that abused you, maybe forgive them and remove the chains you are tied with.”

Susan van Jaarsveld, Senior Director: Human Resources at the University of the Free State, believes that hosting wellness events is a way for the UFS to show that “employees are the most valuable asset of the university and need to be looked after”.

Susan said: “Staff need to know that it is okay not to be okay. However, the UFS has systems to look after your well-being. People need to know that they are not alone, they can make use of the Department of Human Resources’ Careways Employee Wellness Programme.”

Susan believes it was important to host the event, as “staff need face-to-face interaction for their well-being, it helps people to know they are not alone”.

Melissa, the author of the book Weskus Wonderwerk, believes in being unstoppable. She said: “To rise from the trenches, always think positive about yourself, you must exist. You cannot give up; your worth cannot be determined by an individual.” 

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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