Latest News Archive

Please select Category, Year, and then Month to display items

PhD student Alina Ntsiapane dominates in international research pitching contest

10 May 2022 | Story Anthony Mthembu | Photo Supplied

Alina Ntsiapane, a PhD student at the University of the Free State, obtained second place in the partners category of the International Livestock Research Institute’s (ILRI) CapDev Grand Challenge research pitching contest, which took place on 13 April 2022. The pitching contest is the first part of the CapDev Grand Challenge, which is a 10-month process aimed at equipping scientists with the necessary skills to contribute to new research.

Presenting Research to a Tough Panel of Judges

Ntsiapane was one of 30 contestants who presented their research virtually to a panel of esteemed judges. “It was not easy, it was very challenging for me because it was my first time presenting my PhD study and I had to do it live on an international platform,” expressed Ntsiapane. Although each contestant is thoroughly prepared for their respective presentations, Ntsiapane argues that some of the questions asked by the judges can be quite daunting. “Some of their questions were very challenging and I did not know how to respond to them, but they made me aware of ways in which I needed to improve my research,” she stated. However, regardless of the intensity of the pitching contest, Ntsiapane’s research allowed her to progress to the next stage of the CapDev Grand Challenge. She will be part of the rigorous 10-month training process that will begin in June 2022.

Ntsiapane’s Research Project

Ntsiapane’s PhD research focuses on the production of smallholder wool as a means to improve livelihoods in both Thaba ’Nchu and Botshabelo in the Free State. In fact, in the research Ntsiapane highlights that there has been a significant decline in the production of wool within the last three decades. As such, Ntsiapane believes it is imperative to create spaces that allow for the training of small-scale farmers, so that the production of wool can still be a possibility.

Consequently, Ntsiapane hopes that the 10-month training she will receive from the CapDev Grand Challenge will not only allow her to grow but will assist in opening doors for her. “I’m hoping to get exposure and to make connections with policy makers and the donors as well. This will assist me in achieving my goals,” she explained.

Future Endeavours After the Training Course

Subsequent to the training course, Ntsiapane would like to utilise that knowledge by continuing to make her most recent project a reality. Ntsiapane is currently working on developing a television show aimed at providing adequate training to small-scale farmers, so that they are equipped with the necessary knowledge and understanding of the industry in which they find themselves. As such, being part of the CapDev Grand Challenge will allow her to learn some of the necessary ways in which this dream could become a reality.

News Archive

UFS study on cell development in top international science journal

2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.

Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za
18 September 2008

Back

Economic and Management Sciences

Education

Health Sciences

The Humanities

Law

Natural and Agricultural Sciences

Theology and Religion

Open Distance Learning

Business School

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept