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27 May 2022 | Story Leonie Bolleurs | Photo Charl Devenish
Prof Tomas Vetrik
Prof Tomas Vetrik, Professor in the Department of Mathematics and Applied Mathematics, recently delivered his inaugural lecture on the UFS Bloemfontein Campus.

Prof Tomas Vetrik, Professor in the Department of Mathematics and Applied Mathematics at the University of the Free State (UFS), recently delivered his inaugural lecture on the Bloemfontein Campus.

His research area is graph theory, and he mainly focuses on the degree-diameter problem, graph indices, and metric dimension of graphs.

Research focus

According to Prof Vetrik, mathematics was always his favourite subject in school. He also excelled in maths at university and decided to enrol for a course on graph theory while working on his master’s degree. “I liked it, so I also chose topics from graph theory for my PhD thesis,” he says.

In 2014, at the age of 32, he was appointed Associate Professor at the UFS, after postdoctoral research at the University of KwaZulu-Natal and working at the University of Pretoria. An NRF-rated researcher, he has published close to 75 research papers, a third of that as a single author in some of the most well-known journals in his area. Moreover, he was also research supervisor of three PhD and three master’s students.

International collaborations

In the eight years since his appointment at the UFS, Prof Vetrik has made research visits to universities from 14 different countries that have invited him for research collaborations. 

“I am often overseas. I like working from different places. It is interesting to me, and it helps me to be productive,” says Prof Vetrik, explaining some of the inspiration behind his mathematical ideas.

In the next two years, he would like to study more general mathematical problems beyond his current research area.

He says he is addicted to his research. “It overshadows all my other interests.” 

On the rare occasion when he is not working on his research, Prof Vetrik states that he has to keep himself busy. Unable to relax and do nothing, he likes to do sports of some kind or to travel. 

“I am a simple person. I do not even have a TV at home. I use an old-fashioned mobile phone that cannot access the internet,” he says.


News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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