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30 May 2022 | Story Leonie Bolleurs | Photo Leonie Bolleurs
Taking the lead to positively impact
Attending the graduation ceremony in the short learning programme: Teacher Professional Development for Digital Mobile Learning, and Entrepreneurship for SMMEs, were, from the left: Lintle Nthati Radikgomo, Thabile Sylvia Masangane, and André Uys from the Flavius Mareka College in Sasolburg, and Thandeka Mosholi from the UFS.

Gym instructor, homework centre owner, fashion designer, photographer. These are but some of the students who walked across the stage to receive their qualifications after completing an entrepreneurship programme on the South Campus of the University of the Free State (UFS).

The Department of Social Responsibility, Enterprise and Community Engagement on the South Campus recently hosted a ceremony for students in the short learning programme: Teacher Professional Development for Digital Mobile Learning, and Entrepreneurship for SMMEs.

According to Thakane Nteko from the Social Responsibility Projects (SRP), 40 of the 66 students enrolled for the qualification in lecture development completed it, together with the 10 students who registered for the entrepreneurship programme. The students are mainly university and TVET (Technical and Vocational Education and Training) lecturers and self-employed youth.

She says the department aims to enhance teaching and learning in the Free State, be it for school learners, schoolteachers, TVET college lecturers, or the youth. Key in this initiative is the UFS, in partnership with Sector Education and Training Authorities (SETAs) and other organisations involved in community development, to make a positive difference in communities where there is a need.

Addressing social injustices
Positively impacting the youth of South Africa is of critical importance to the UFS. “Creating opportunities and growth through leading, learning, and teaching, is not only valid for the young intellectuals who have the chance to qualify themselves through tertiary studies. It is also applicable to the disadvantaged communities exposed to poor education. The UFS SRP serve as the vehicle to address this social injustice,” states Thandeka Mosholi, Head of the Department of Social Responsibility, Enterprise and Community Engagement.

She trusts that Social Responsibility Projects has established itself as a supporter of disadvantaged communities by responding to the call to positively impact the future of South African youth. “Our passion resonates with those who desire to open opportunities and bring purpose to gifted learners born in circumstances they did not choose, by being leaders in school change,” she says.

Destined for greatness
Delivering messages of encouragement at the event was KB Lebusho, CEO of the Free State Chamber of Commerce and Industry. Addressing the group of entrepreneurs, lecturers, and teachers, he told them that they are destined for greatness. “But until you believe in yourself, things will not change for you. It is important that you have clarity about your dreams and goals.”

Advocate Shirly Hyland, Director: Kovsie Phahamisa Academy, also left the students with a message of support. “By paying education forward, we can change the world. The power to touch the lives around you, lies in your hands. Enjoy taking the knowledge you have learned into your communities,” she said.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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