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05 May 2022 | Story Leonie Bolleurs | Photo Supplied
Prof Hennie van Coller and Prof Hendrik Swart
Prof Hennie van Coller, left, received the the NP van Wyk Louw medal, and Prof Hendrik Swart, right, received the Havenga Prize for Physical Sciences.

The board of the Suid-Afrikaanse Akademie vir Wetenskap en Kuns (SAAWK) recently (22 April) announced the winners of the 2022 prizes. The academy, which was established in 1901, aims to promote the use of Afrikaans in science and the arts.

Havenga Prize for Physical Sciences

Prof Hendrik Swart, NRF B1-rated researcher, SARChI Research Chair in Solid-state Luminescent and Advanced Materials, and Senior Professor in the Department of Physics at the University of the Free State (UFS), received the prestigious Havenga Prize for Physical Sciences.

He says it is an honour to receive this award. “When I look at the list of names that have received the award in the past, I am very humbled and surprised to receive such an award.”

The Havenga Prize, for which candidates are specifically judged on research publications and evidence of their promotion of Afrikaans, has been awarded annually for the past 77 years for original research in the natural sciences or a technical field. 

A collaboration with researchers from the Nelson Mandela University (NMU) on semiconductor materials that improve the efficiency of solar cells, resulted in Prof Japie Engelbrecht (Emeritus Professor, NMU) nominating Prof Swart for this award. He is involved in an NRF collaborative research project with NMU and Linköping University in Sweden.

Prof Swart has played an important role in the acquisition of numerous research devices for analysing the thin layer of phosphor, and the semiconductor devices that can be made from such materials. His research and zeal for his work led to the establishment of the national nano-surface characterisation facility (NNSCF) containing state-of-the-art surface characterisation equipment. 

The PHI Quantes XPS system, for instance, is the first in Africa and one of only 20 in the world. The Quantes XPS system uses X-rays to determine the chemical composition of molecules on the surface of a sample. The system is unique in the sense that it also has an extra X-ray source that can determine the chemical state below the surface, which was not possible in the past. This will help to dictate the position of defects in phosphor materials, which will consequently enable the department to create better phosphor for solid-state lighting as well as solar cell applications.

The most meaningful for him, however, was the production of several well-trained postgraduate students and the generation of high-impact, well-cited scientific publications.

This award, one of several awards he has received during his career, does not signify the end of the road. On the contrary, he is looking forward to improving solar cells by using the phosphor materials they have manufactured, applying it on glass windows doped with phosphors to generate electricity.

NP van Wyk Louw Medal and Alba Bouwer Prize for children's literature

The NP van Wyk Louw Medal was awarded to Prof Hennie van Coller, a researcher who is also affiliated to the UFS. Prof Van Coller, currently an emeritus outstanding professor and research fellow at the university, was a former Head of the UFS Department of Afrikaans and Dutch, German and French, as well as Chairperson of SAAWK. He is known for his impact on the literary world, both locally and internationally, through the quality of his scientific articles and books. 

According to SAAWK, the body awards the NP van Wyk Louw Medal for a person’s creative contributions to the exploitation, organisation, and continuous development of a section of the humanities, significantly contributing to the advancement of the humanities.

Jaco Jacobs, the children’s author of more than 170 books who recently presented the 35th DF Malherbe Memorial Lecture at the UFS, was also awarded for his work. Jacobs, also a UFS alumnus, received the Alba Bouwer Prize for children's literature. The prize, which is awarded every three years, was presented to Jacobs for the book Die boekwinkel tussen die wolke, written during the COVID-19 lockdown period. 

SAAWK will present the awards later this year during two virtual award ceremonies in July. 

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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