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28 November 2022 | Story Rulanzen Martin | Photo Anja Aucamp
Prof Melanie Walker
Prof Melanie Walker is one of two NRF A1-rated scholars at the UFS.

The Higher Education and Human Development (HEHD) research group under the leadership of Prof Melanie Walker has grown to become a pocket of academic excellence and innovation at the UFS. “The group’s research positions universities (if ‘reimagined’) as potentially powerful sites for achieving human development by challenging the status quo and entrenched interests and inequalities,” Prof Walker notes. 

HEHD researchers draw substantially on the capability approach, which offers a contribution to higher education in South Africa, primarily because it derives from a normative framework that places human flourishing as its primary goal, chiming with the country’s transformation goals.

Prof Walker is an internationally acclaimed researcher and academic and one of three A-rated National Research Foundation (NRF) scholars at the UFS. In 2021, she was elected as the first president of the international Human Development and Capability Association (HDCA) from the Global South. Back then, Prof Walker said the UFS already had a strong research presence within the HDCA, and her group was known for its work in African higher education. The HDCA brings together academics who generate ideas and research on human development.

The research group, which was founded by Prof Walker, is an embodiment of the quality and of the impact elements of the institutional narrative of the UFS. The HEHD is now happily based in the Centre for Development Support within the UFS Faculty of Economic and Management Sciences.

Top-tier research outputs from HEHD

The outputs of the HEHD research group have a far-reaching impact, given the nature of its national and international affiliated researchers, students, and collaborators. Members of the group have published 19 peer-reviewed books since 2013, and since 2016, the HEHD has graduated 20 PhDs whose research focuses on diverse aspects of higher education and capabilities across the sub- Saharan region. A range of international examiners in the USA, the UK and Europe attest to the quality of the HEHD’s doctoral graduates.

“I am immensely proud of the quality of the research and collective ethos of our graduate students and our researchers and, as importantly, the substantive focus on human development and social justice in and through higher education in Africa,” Prof Walker says. “As Professor Tristan McCowan and others have noted, this group is quite unique internationally,” she continues.

Projects and research collaborations

The numerous institutional and national and international research collaborations are also testament to the interdisciplinarity of Prof Walker’s academic approach. Various recent and current projects attest to this, for example, the recently completed Miratho project on inclusive higher education learning outcomes for low-income rural youth with Birmingham and Nottingham.

Some of the the book titles that have been published by HEHD members past and present, on display on the wall in the Benito Khotseng Building on the Bloemfontein Campus. (Photo: Anja Aucamp) 


A further current example is the project under the Transforming Education for Sustainable Futures (TESF) with Bristol and Rhodes led by Dr Mikateko Mathebula, and a new edited book underway with Alejandra Boni and Diana Velasco (Spain) on higher education and reparative futures.

 
Furthermore, national collaborations such as the project with colleagues in the Centre for Development Support at the UFS and the University of Pretoria, which will be investigating the sustainable (ecologically and socially), developmental South African university and justice facing university futures from a variety of stakeholder 
perspectives.

This research project is informed by the 17 Sustainable Development Goals, because achieving them cannot be done without the contributions of higher education institutions.

It is thus evident that under the leadership of Prof Walker, the HEHD research group is now established as one of the finest research groups at the UFS and contributes actively to the research and academic excellence at the university.

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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