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28 November 2022 | Story Rulanzen Martin | Photo Anja Aucamp
Prof Melanie Walker
Prof Melanie Walker is one of two NRF A1-rated scholars at the UFS.

The Higher Education and Human Development (HEHD) research group under the leadership of Prof Melanie Walker has grown to become a pocket of academic excellence and innovation at the UFS. “The group’s research positions universities (if ‘reimagined’) as potentially powerful sites for achieving human development by challenging the status quo and entrenched interests and inequalities,” Prof Walker notes. 

HEHD researchers draw substantially on the capability approach, which offers a contribution to higher education in South Africa, primarily because it derives from a normative framework that places human flourishing as its primary goal, chiming with the country’s transformation goals.

Prof Walker is an internationally acclaimed researcher and academic and one of three A-rated National Research Foundation (NRF) scholars at the UFS. In 2021, she was elected as the first president of the international Human Development and Capability Association (HDCA) from the Global South. Back then, Prof Walker said the UFS already had a strong research presence within the HDCA, and her group was known for its work in African higher education. The HDCA brings together academics who generate ideas and research on human development.

The research group, which was founded by Prof Walker, is an embodiment of the quality and of the impact elements of the institutional narrative of the UFS. The HEHD is now happily based in the Centre for Development Support within the UFS Faculty of Economic and Management Sciences.

Top-tier research outputs from HEHD

The outputs of the HEHD research group have a far-reaching impact, given the nature of its national and international affiliated researchers, students, and collaborators. Members of the group have published 19 peer-reviewed books since 2013, and since 2016, the HEHD has graduated 20 PhDs whose research focuses on diverse aspects of higher education and capabilities across the sub- Saharan region. A range of international examiners in the USA, the UK and Europe attest to the quality of the HEHD’s doctoral graduates.

“I am immensely proud of the quality of the research and collective ethos of our graduate students and our researchers and, as importantly, the substantive focus on human development and social justice in and through higher education in Africa,” Prof Walker says. “As Professor Tristan McCowan and others have noted, this group is quite unique internationally,” she continues.

Projects and research collaborations

The numerous institutional and national and international research collaborations are also testament to the interdisciplinarity of Prof Walker’s academic approach. Various recent and current projects attest to this, for example, the recently completed Miratho project on inclusive higher education learning outcomes for low-income rural youth with Birmingham and Nottingham.

Some of the the book titles that have been published by HEHD members past and present, on display on the wall in the Benito Khotseng Building on the Bloemfontein Campus. (Photo: Anja Aucamp) 


A further current example is the project under the Transforming Education for Sustainable Futures (TESF) with Bristol and Rhodes led by Dr Mikateko Mathebula, and a new edited book underway with Alejandra Boni and Diana Velasco (Spain) on higher education and reparative futures.

 
Furthermore, national collaborations such as the project with colleagues in the Centre for Development Support at the UFS and the University of Pretoria, which will be investigating the sustainable (ecologically and socially), developmental South African university and justice facing university futures from a variety of stakeholder 
perspectives.

This research project is informed by the 17 Sustainable Development Goals, because achieving them cannot be done without the contributions of higher education institutions.

It is thus evident that under the leadership of Prof Walker, the HEHD research group is now established as one of the finest research groups at the UFS and contributes actively to the research and academic excellence at the university.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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