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24 November 2022 | Story Andre Damons | Photo Supplied
Thaba Nchu health web new
One Health Warriors with the scholar pledge cloth after scholars made a pledge to take care of their pets at St Paul’s Primary School in Thaba Nchu.

International One Health Day is held annually on 3 November. The goal of the day is to educate and increase awareness of One Health to encourage a collaborative effort between multiple disciplines, promoting the concept that the interactions between humans, animals, and the environment impact the health of people, animals, plants, and the environment.

The aptly named One Health Warriors, a student group comprising postgraduate students from the Division of Virology at the University of the Free State (UFS), was formed in 2016. The One Health Warriors annually participate in arranging a One Health event to celebrate International One Health Day. What is One Health? What zoonotic diseases should the public be aware of? How do zoonoses affect the healthcare provider? These are all questions that the student group addresses in their events.  

In 2022, the One Health Warriors targeted scholars to participate in their annual event. It is important for scholars to start learning about One Health from an early age, because most of them do not understand the importance of taking care of their pets. They are not always aware of the diseases that can be transmitted from animals to humans and how to protect themselves.

It is for this reason that postgraduate students from the Division of Virology took One Health awareness and science communication to the classrooms of Ratau Primary and St. Pauls Primary schools in Thaba Nchu, Bloemfontein. Grade 6 scholars were included in the events and a total of 224 learners participated in the day. 

According to Prof Felicity Burt, an expert in arbovirology in the Division of Virology and the National Health Laboratory Services (NHLS) – who holds an NRF-DST South African Research Chair in Vector-borne and Zoonotic Pathogens Research – and Tumelo Sekee, PhD student and research assistant in the School of Pathology, they decided to start with primary schools as they believe it is good to start teaching scholars from an early age to take care of their pets and understand the importance of One Health. 

Making the youth aware 

The focus was on making the youth aware of diseases transmitted from animals to humans, how to protect themselves from zoonotic diseases, and how to take care of their pets. They used role-play activities in which the learners were educated about the risk of contracting the rabies virus and some of the signs that may be shown by rabid dogs. The learners also got to learn about the importance of reporting any bites and getting appropriate treatment from the clinics.  

Rabies circulates within this area and is a high risk for children who play with stray dogs. They were advised about vaccines to protect their dogs against infection and thereby protecting themselves. They were shown how to remove ticks from the dogs, and the importance of not eating a dead animal whose cause of death is unknown. 

“The children were advised on the potential for tuberculosis (TB bovis) to occur in their livestock and the potential for spread to humans. Pictures were circulated among the learners showing them what a rabid dog or animal might look like and how an animal with TB bovis may present. The learners were taught about the importance of hand washing. In the finale of the event, the learners made a pledge to take care of their pets, and this was confirmed with painted hands on our One Health posters,” says Tumelo Sekee.

According to Prof Burt, One Health is an approach that recognises that the health of people is closely connected to the health of animals and their shared environment. One Health is not new, but it has become more important in recent years. “This is partly because many factors have influenced the way humans interact with animals (domestic and wild), plants, and our environment. These changes have led to the spread of known (endemic) pathogens and the emergence of novel pathogens and zoonotic diseases, which are diseases that can spread between animals and people. The recent pandemic is an example of how zoonotic transmission of a pathogen from wildlife to humans has a devastating public health impact,” explains Prof Burt.

Positive feedback
Sekee says the feedback was extremely positive; this may be because the communication was done in the learners’ mother tongue, Setswana, which made it easy for them to understand. Says Sekee: “There were many questions and discussions after the play, which suggested that the scholars showed interest in learning about a One Health approach. The scholars were also enthusiastic about participating in future events of the One Health warriors.”

The postgraduate One Health group previously also visited schools in Botshabelo and Bloemfontein, as well as farm workers in Kroonstad. They now plan to visit other schools in the Free State so that the One Health message can reach as many people as possible.  

News Archive

Research contributes to improving quality of life for cancer patients
2016-11-21

Description: Inorganic Chemistry supervisors  Tags: Inorganic Chemistry supervisors

Inorganic Chemistry supervisors in the Radiopharmacy
Laboratory during the preparation of a typical complex
mixture to see how fast it reacts. Here are, from the left,
front: Dr Marietjie Schutte-Smith, Dr Alice Brink
(both scholars from the UFS Prestige
Scholar Programme), and Dr Truidie Venter (all three
are Thuthuka-funded researchers).
Back: Prof André Roodt and Dr Johan Venter.
Photo: Supplied

Imagine that you have been diagnosed with bone cancer and only have six months to live. You are in a wheelchair because the pain in your legs is so immense that you can’t walk anymore – similar to a mechanism eating your bones from the inside.

You are lucky though, since you could be injected with a drug to control the pain so effective that you will be able to get out of the wheelchair within a day-and-a-half and be able to walk again. Real-life incidents like these provide intense job satisfaction to Prof André Roodt, Head of Inorganic Chemistry at the University of the Free State (UFS). The research, which is conducted by the Inorganic Group at the UFS, contributes greatly to the availability of pain therapy that does not involve drugs, but improves the quality of life for cancer patients.

The research conducted by the Inorganic Group under the leadership of Prof Roodt, plays a major role in the clever design of model medicines to better detect and treat cancer.

The Department of Chemistry is one of approximately 10 institutions worldwide that conducts research on chemical mechanisms to identify and control cancer. “The fact that we are able to cooperate with the Departments of Nuclear Medicine and Medical Physics at the UFS, the Animal Research Centre, and other collaborators in South Africa and abroad, but especially the methodology we utilise to conduct research (studying the chemical manner in which drugs are absorbed in cancer as well as the time involved), enhances the possibility of making a contribution to cancer research,” says Prof Roodt.

Technique to detect cancer spots on bone
According to the professor, there are various ways of detecting cancer in the body. Cancer can, inter alia, be identified by analysing blood, X-rays (external) or through an internal technique where the patient is injected with a radioactive isotope.

Prof Roodt explains: “The doctor suspects that the patient has bone cancer and injects the person with a drug consisting of an isotope (only emits X-rays and does no damage to tissue) that is connected to a phosphonate (similar to those used for osteoporosis). Once the drug is injected, the isotope (Technetium-99m) moves to the spot on the bone where the cancer is located. The gamma rays in the isotope illuminate the area and the doctor can see exactly where treatment should be applied. The Technetium-99m has the same intensity gamma rays as normal X-rays and therefore operates the same as an internal X-ray supply.” With this technique, the doctor can see where the cancer spots are within a few hours.

The same technique can be used to identify inactive parts of the brain in Alzheimer patients, as well as areas of the heart where there is no blood supply or where the heart muscle is dead.

Therapeutic irradiation of cancer
For the treatment of pain connected with cancer, the isotope Rhenium-186 is injected. Similar to the manner in which the Technetium-99m phosphonate compound is ingested into the body, the Rhenium-186 phosphonate travels to the cancer spots. Patients thus receive therapeutic irradiation – a technique known as palliative therapy, which is excellent for treating pain. A dosage of this therapy usually lasts for about two months.

The therapy is, however, patient specific. The dosages should correspond with the occurrence and size of cancer spots in the patient’s body. First, the location of the cancer will be determined by means of a technetium scan. After that, the size of the area where the cancer occurs has to be determined. The dosage for addressing total pain distribution will be calculated according to these results.

Technique to detect cancer spots on soft tissue
Another technique to detect cancer as spots on bone or in soft tissue and organs throughout the body is by utilising a different type of irradiation, a so-called PET isotope. The Fluor-18 isotope is currently used widely, and in Pretoria a machine called a cyclotron was produced by Dr Gerdus Kemp, who is a former PhD graduate from the Inorganic Research Group. The F-18 is then hidden within a glucose molecule and a patient will be injected with the drug after being tranquillised and after the metabolism has been lowered considerably. The glucose, which is the ‘food' that cancer needs to grow, will then travel directly to the cancer area and the specific area where the cancer is located will thus be traced and ‘illuminated’ by the Fluor-18, which emits its own 'X-rays'.

In the late 80s, Prof Roodt did his own postdoctoral study on this research in the US. He started collaborating with the Department of Nuclear Medicine at the UFS in the early 90s, when he initiated testing for this research.

Through their research of more than 15 years, the Inorganic Group in the Department of Chemistry has made a major contribution to cancer research. Research on mechanisms for the detection of cancer, by designing new clever chemical agents, and the chemical ways in which these agents are taken up in the body, especially contributes to the development in terms of cancer therapy and imaging, and has been used by a number of hospitals in South Africa.

The future holds great promise
Prof Roodt and his team are already working on a bilateral study between the UFS and Kenya. It involves the linking of radio isotopes, as mentioned above, to known natural products (such as rooibos tea), which possess anti-cancer qualities.

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