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11 October 2022 | Story Nonsindiso Qwabe
Qwaqwa research conference
Unpacking the role of research in society. From left: Lukhona Mnguni, Prof Pearl Sithole, Prof Dipane Hlalele, and Prof Percy Hlangothi

From socio-political dynamics and creativity in the Basotho language, to the improvement of water conditions in the upper Tugela River and antifungal studies of Cydonia oblonga extracts (known as kwepere in Sesotho) – these are just some of the highlights of the research presented at the UFS Qwaqwa Campus research conference.

With a theme focused on research as a tool for the betterment of humanity, the two-day research conference provided a space for the campus to showcase its research for sustainable development in the Afromontane region and beyond, conducted by academics and postgraduate students alike. The two-day event comprised oral student and staff presentations and sessions, with shorter presentations on the second day.

As global trends continue to challenge society to solve big and immediate problems, there has been a natural turn towards research that can make a lasting impact on local and global platforms. Through student and academic presentations, the conference provided insights into how the UFS is playing an active role in responding to some of these challenges by being outwardly focused in their approaches to problem-solving.

Balancing the sciences, industry, and society

With an intentional focus on interdisciplinarity, the guest speakers – all in different science fields – offered solutions to conducting impactful research through the lens of their own work. Prof Percy Hlangothi is currently an Associate Professor of Physical and Polymer Chemistry at Nelson Mandela University (NMU) and inaugural Director of the Centre for Rubber Science and Technology, a research entity in the Faculty of Science at the same institution. By describing his work, particularly on the production of tyres, he focused on the importance of achieving rapport between the sciences, industry, and society.

The second keynote speaker was Lukhona Mnguni, a governance, politics and development specialist and PhD candidate in Political Science at the University of KwaZulu-Natal. He currently serves as the Head of Policy and Research at the Rivonia Circle. Mnguni focused his talk on the breakthroughs of research as stemming from people, and not academic disciplines themselves. Mnguni issued a hard call towards a reflection of what the intellectual and scholarly quest for knowledge is doing to society, emphasising the need for societal involvement in issues pertaining to crises in society.

Prof Dipane Hlalele, Professor of Education at UKZN and a C2 NRF-rated researcher (2022-2027), was the final speaker for the conference. He anchored his talk on the importance of having philosophical frames behind scholarship, and spoke against approaching rural areas as lacking knowledge, to a stance of mutual understanding of knowledge schemes and models of intervention.

Campus focused on making an impact outwardly

Marking the opening of the conference, Dr Martin Mandew, Qwaqwa Campus Principal, said the campus was trying to punch above its weight and evolve its research and knowledge outputs. “We cannot just be consumers of knowledge and finished products that come from abroad. We have to produce our own knowledge that speaks to our own unique circumstances and makes complete sense of our capacities,” he said.

The conference also served as the launch platform for the campus research strategy. During the launch, Prof Pearl Sithole, Campus Vice-Principal: Academic and Research, said the strategy was centred on five frontiers. “We are trying to align what we do outwardly in terms of impact and are working on ourselves as per the commitments of the strategy. We do this excellently, because we want to advance knowledge – there is no question about that – and we put pressure on each other to do that. It does not mean that it will be easy, but we are going to engineer it such that originality and the advancement of knowledge is happening.”

The conference concluded with a prize-giving session for the best oral student presentations.

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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