Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
11 October 2022 | Story Nonsindiso Qwabe
Qwaqwa research conference
Unpacking the role of research in society. From left: Lukhona Mnguni, Prof Pearl Sithole, Prof Dipane Hlalele, and Prof Percy Hlangothi

From socio-political dynamics and creativity in the Basotho language, to the improvement of water conditions in the upper Tugela River and antifungal studies of Cydonia oblonga extracts (known as kwepere in Sesotho) – these are just some of the highlights of the research presented at the UFS Qwaqwa Campus research conference.

With a theme focused on research as a tool for the betterment of humanity, the two-day research conference provided a space for the campus to showcase its research for sustainable development in the Afromontane region and beyond, conducted by academics and postgraduate students alike. The two-day event comprised oral student and staff presentations and sessions, with shorter presentations on the second day.

As global trends continue to challenge society to solve big and immediate problems, there has been a natural turn towards research that can make a lasting impact on local and global platforms. Through student and academic presentations, the conference provided insights into how the UFS is playing an active role in responding to some of these challenges by being outwardly focused in their approaches to problem-solving.

Balancing the sciences, industry, and society

With an intentional focus on interdisciplinarity, the guest speakers – all in different science fields – offered solutions to conducting impactful research through the lens of their own work. Prof Percy Hlangothi is currently an Associate Professor of Physical and Polymer Chemistry at Nelson Mandela University (NMU) and inaugural Director of the Centre for Rubber Science and Technology, a research entity in the Faculty of Science at the same institution. By describing his work, particularly on the production of tyres, he focused on the importance of achieving rapport between the sciences, industry, and society.

The second keynote speaker was Lukhona Mnguni, a governance, politics and development specialist and PhD candidate in Political Science at the University of KwaZulu-Natal. He currently serves as the Head of Policy and Research at the Rivonia Circle. Mnguni focused his talk on the breakthroughs of research as stemming from people, and not academic disciplines themselves. Mnguni issued a hard call towards a reflection of what the intellectual and scholarly quest for knowledge is doing to society, emphasising the need for societal involvement in issues pertaining to crises in society.

Prof Dipane Hlalele, Professor of Education at UKZN and a C2 NRF-rated researcher (2022-2027), was the final speaker for the conference. He anchored his talk on the importance of having philosophical frames behind scholarship, and spoke against approaching rural areas as lacking knowledge, to a stance of mutual understanding of knowledge schemes and models of intervention.

Campus focused on making an impact outwardly

Marking the opening of the conference, Dr Martin Mandew, Qwaqwa Campus Principal, said the campus was trying to punch above its weight and evolve its research and knowledge outputs. “We cannot just be consumers of knowledge and finished products that come from abroad. We have to produce our own knowledge that speaks to our own unique circumstances and makes complete sense of our capacities,” he said.

The conference also served as the launch platform for the campus research strategy. During the launch, Prof Pearl Sithole, Campus Vice-Principal: Academic and Research, said the strategy was centred on five frontiers. “We are trying to align what we do outwardly in terms of impact and are working on ourselves as per the commitments of the strategy. We do this excellently, because we want to advance knowledge – there is no question about that – and we put pressure on each other to do that. It does not mean that it will be easy, but we are going to engineer it such that originality and the advancement of knowledge is happening.”

The conference concluded with a prize-giving session for the best oral student presentations.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept