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26 October 2022 | Story Leonie Bolleurs | Photo Supplied
Dr Carol Chi Ngang
Dr Carol Chi Ngang, a category C2-rated researcher and research fellow in the UFS Free State Centre for Human Rights, has been appointed as the UNDP Human Rights Research Chair at the National University of Lesotho, where he is currently affiliated.


A National Research Foundation category C2-rated researcher and research fellow in the Free State Centre for Human Rights at the University of the Free State (UFS), Dr Carol Chi Ngang, has been appointed as United Nations Development Programme (UNDP) Human Rights Research Chair at the National University of Lesotho, where he is currently affiliated. 

According to Dr Ngang, the Human Rights Chair was established with the broad mandate to undertake and promote cutting-edge policy research, curriculum development, and community engagement. He says the chair is envisaged to generate a steady stream of research outputs on various aspects of human rights in Lesotho, and most importantly, to explore the human rights components of the Sustainable Development Goals.

For establishing the Human Rights Chair and funding its programme activities, Dr Ngang expresses his gratitude to the United Nations Tripartite Partnership (UNTPP), the Office of the High Commissioner for Human Rights (OHCHR), and the United Nations Development Programme (UNDP) Lesotho.

Knowledge-based foundation for a human rights culture

Dr Ngang states that the establishment of the UNDP Human Rights Chair in the Faculty of Law at the National University of Lesotho is not only timely, but also indispensable in the sense that it provides the opportunity to lay a solid knowledge-based foundation for a human rights culture in Lesotho to respond to and seek to redress the exigencies and the lived experiences of the Basotho. 

“With the country’s political landscape characterised for the last decades by, among others, a distressed economy, shaky coalition governments, and instability, Lesotho’s human rights record is not an impressive one.”

Dr Ngang elaborates, “In spite of a cabinet decision taken as far back as 1995 and the adoption of the Sixth Amendment to the Constitution Act in 2011 – with explicit provision for the establishment of the Lesotho Human Rights Commission – 27 years down the line the august institution, which is supposed to oversee the promotion and protection of human rights in Lesotho, is yet to see the light of day. Lesotho remains one of the few countries in Africa and around the world that is yet to put in place a human rights commission to ensure protection of the vulnerable population, of which the constitutionally guaranteed fundamental rights are threatened on a daily basis.”

According to him, one of the most pressing issues in the human rights field currently, is the establishment of the Lesotho Human Rights Commission. “It is a central concern not only for our funders and the Ministry of Law and Justice and the many other active forces that have invested time and resources in the process, but importantly, also for the Lesotho society at large,” he states.

“Without the commission, the vulnerability of the population is multiplied.”

Effecting real transformation in the human rights situation in Lesotho

Dr Ngang says in the absence of a human rights commission, besides focusing on research and the dissemination of knowledge, the Human Rights Chair will additionally cover gaps in the areas of advocacy, amicus curiae interventions, and public interest litigation in human rights matters before the courts.

“It is our anticipation that the research outputs generated by the Human Rights Chair will be utilised productively, including by Lesotho-based civil society organisations, to inform policy advocacy and most essentially, leverage policy formulation, decision making, and resource allocation for the realisation of human rights in the country.”

Dr Ngang also foresees that it will shape the direction of governance and governmental actions in meeting the global Sustainable Development Goal targets, as well as the strategic objective of national transformation as outlined in the Lesotho National Strategic Development Plan II. 

The Human Rights Chair, he says, has established working relations with the Ministry of Law and Justice, as well as a collaborative partnership with the Lesotho NGO sector, and envisages doing so with the private sector and other major stakeholders. “These strategic alliances are intended to ensure that knowledge generated by the chair through research is utilised by the relevant stakeholders to effect real transformation as far as the human rights situation in Lesotho is concerned.”

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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