Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
15 September 2022 | Story NONSINDISO QWABE | Photo UFS Photo Gallery
UFS Qwaqwa Campus
The UFS Qwaqwa Campus.

Recent global happenings have challenged communities and humanity’s capability to solve immediate and major problems. Science has been one of the spaces in which the communities have looked for solutions regarding real threats to lives related to climate change, wars, as well as social and health pandemics. The Qwaqwa Campus will be showcasing Qwaqwa Campus research and scholarship at this year’s research conference, a two-day event which will be held in person, on 29-30 September 2022 at the Senate Hall on campus.

‘Scholarship, Innovation and Science: how can research be used as a tool for the betterment of society?’

Under this theme, the conference will be a space for intellectual debate and the processing of scholarship in innovation, said Prof Pearl Sithole, Vice-Principal: Academic and Research. “Some of the societal challenges have been urgent and pressing, yet some are slow dilemmas shattering the hope of generations for a better future. This conference will present the products of ‘disciplinary and scholarly crafts’, but it also seeks to explore whether science does (or should) have a strategic direction, and perhaps this is what the concept of innovation should entail. It will ponder on whether in the age-old binary between exploratory research and praxis there is a defeating taming of the entrepreneurial edge for the expanse of science in Africa,” she said.

Prof Sithole said the campus would also be launching its research strategy for 2022 to 2026.

Guest speakers include:

• Prof Percy Hlangothi is an Associate Professor of Physical and Polymer Chemistry at the Nelson Mandela University. He is also the inaugural Director of the Centre for Rubber Science and Technology, a research entity in the Faculty of Science at the same institution.

• Mr Lukhona Mnguni is a governance, politics, and development specialist and prolific political analyst specialising in Africa and international relations, as well as a PhD intern at the University of KwaZulu-Natal. He currently serves as the Head of Policy and Research at the Rivonia Circle. His work includes a current affairs analytical show on eNCA dubbed On the Spot with Lukhona Mnguni.

• Prof Dipane Hlalele is a Professor of Education and a C2 NRF-rated researcher. He is a highly rated scholar in inclusive education, critical pedagogy, and educational psychology at the University of KwaZulu-Natal. Prior to joining UKZN as an associate professor in 2017, he was an assistant dean and senior lecturer at the UFS, a college of education lecturer, and a high school deputy principal and teacher. 

To RSVP please click here on or before 19 September 2022.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept