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24 April 2023 | Story Gerda-Marié van Rooyen | Photo Charl Devenish
Jenna Clarkson
Jenna Clarkson is a devout communications student and a karateka. She had to deal with several health challenges during her studies, but nevertheless dreams of obtaining her PhD in Communication at the UFS.

Overcoming numerous health obstacles during her studies, Jenna Clarkson is in high spirits after obtaining her degree from the University of the Free State (UFS). While most students enjoyed an active social and campus life, she often had to visit the hospital while studying. Receiving her BA Integrated Organisational Communication qualification during the April 2023 graduation ceremony has been a healing balm after many years of pain. 
 
The Faculty of the Humanities graduate was diagnosed with type 2 diabetes in 2021. In 2022, after several physiotherapists and emergency room visits, she was also diagnosed with juvenile disc disorder and sacroiliitis. The latter condition affects one or both sacroiliac joints where the lower spine and pelvis meet and may cause pain in one or both legs. 

Initially, Jenna assumed she had hurt herself during karate practice, but the pain would not subside. “I would randomly lose feeling in my legs and couldn’t sit. I spent a year in pain and struggled to walk, lift heavy objects, cough, and sleep on my side. I struggled with the fact that this was going to be an issue for the rest of my life.” 

However, with a lot of love from her friends, support from her lecturers, and grace with herself, Jenna learned how to handle the pain and to realise when she has met her limits. This student from Johannesburg says that although pain is frustrating and overwhelming, having emotional support helps. “Sometimes just having someone to listen and be there is the best thing.”

The journey to the graduation stage might have been difficult for this high-flyer, but it was a worthwhile undertaking. 

“I feel over the moon, and a little overwhelmed that it happened,” says Jenna about getting her degree in communications. Loving her field of study, she attended class eagerly and enjoyed her modules. “I love that I am allowed to create, I get to make something. There’s nothing more amazing than getting a brief and being able to look at it and create something from it that nobody else would have created. The bonus is that I am quite good at it too,” adds the student who is currently doing her honours degree at the UFS. 

Getting her first degree from the UFS, Jenna is determined to excel in her chosen field. 

“I would like to get my honours degree cum laude and do a PhD degree, but I am taking it one degree at a time. If it doesn’t work out that way, it’s okay. I am very good at figuring things out and making a plan.”

Jenna is determined to make her parents proud. “Having lost my dad at four, I do everything with the hope that he would be proud of my choices. My mom sacrificed a lot to give me the best life she could.”

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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