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16 August 2023 | Story Angela Stott | Photo Supplied
Participants of the UFS Creative Clubs Programme
23 grade 10 participants in the UFS Creative Clubs Programme proudly pose with their awards.

All 23 grade 10 learners taking part in the University of the Free State’s (UFS) Creative Clubs Programme were awarded medals at the Bloemfontein regional Eskom Expo for Young Scientists (EYS) competition from 3 to 5 August 2023.

The learners, who attend Bloemfontein township schools, had been working on their projects for over a year as part of the Creative Clubs Programme, which is run by the UFS Faculty of Education. Guided by veteran Expo facilitators Dr Angela Stott and Coretha van den Heever, they attended 30 sessions on the UFS South Campus, with a total of 140 hours of face-to-face contact time, coupled with many hours of individual work at home, to prepare for the competition.

Their hard work paid off handsomely, with all 23 learners (who worked on 21 projects) achieving medals: six bronze, seven silver, and eight gold. Additionally, five of the learners won best-in-category awards, three won SA Youth Water prizes, and three were shortlisted for the international EYS competition.

“As an introvert, I found it difficult to explain my project to people, but I’ve developed communication skills and confidence through Expo,” said 15-year-old Nicolas Hugo, from Kagisho Secondary School, whose project won a gold medal. Nicolas studied water pollution levels at two inflow sites in the Bloudam catchment area, as well as the dam itself and its outflow, showing the astounding cleaning effectiveness of water reeds.

In addition to his gold medal he won the prize for the best project in his category, a special award in the category of water projects, and for the Best Development Project.

The UFS has a strong commitment to community engagement, and has been working with township schools throughout the province via school-university partnerships for over a decade. The 2023 Bloemfontein EYS competition celebrated the legacy of these partnerships not only through the 23 learners who were directly involved in the UFS programme over the past year, but also through the participation of 14 learners from two schools (Senakangwedi and Setjhaba Se Maketse) in Botshabelo as a direct result of the UFS’s work in those schools in the past. Before UFS ended its partnership with these schools, learners who had been involved in Expo programmes conducted by Dr Stott established science clubs in their schools. These clubs have continued to operate years after UFS exited the schools and the founding learners matriculated. This year these clubs yielded the winning project, Solar Power Stand, by Simthembile Hlahliso and Kabelo Sekoere from Senakangwedi High School.

Many of the learners said they have learned important skills through this process. “I didn’t know how to use a computer, but now I’m so good,” said Sylvia Hlangabeza, who won a gold award.

“I’m so proud of her, I cried,” said Sylvia’s proud mother.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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