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25 August 2023 | Story Naledi Mokhasinyane | Photo Thandiswa Sihlezana
Tlotlisang Mhlambiso
Tlotlisang Mhlambiso with his new book, A Journey Worth the Ride.

Tlotlisang Mhlambiso, a University of the Free State (UFS) BEd student in his final year, wears multiple hats as an author, poet, and Teaching Assistant. And the 23-year-old’s literary prowess continues to grow: He launched his second book, a collection of short stories titled A Journey Worth the Ride, at the UFS Academy for Multilingualism recently. 

Hailing from Lugcadweni village in the Eastern Cape's Mount Fletcher (Tlokoeng), Mhlambiso self-published his debut poetry book, Ukuphuma Kwelanga, in 2020. His debut book received a public launch on 14 June 2023 at the UFS’s Sasol Library, and his second book was launched on 11 August.

Unveiling "A Journey Worth the Ride": iCAN Project hosts the remarkable launch

The launch of A Journey Worth the Ride was hosted by the iCAN Project, led by Mhlambiso's former lecturer Dr Peet van Aardt. Mhlambiso’s book delve into resilience, sorrow, and love. He was recognised by the National Youth Development Agency as 2023's Education Trailblazer. He says he hopes to battle illiteracy through his poetry and stories, which shone at the National Arts Festival and are preserved in the Amazwi South African Museum of Literature. He has also co-authored an international journal spanning continents.

Inspired by an English teacher's introduction to the poem ‘Africa My Africa’ by David Diop, Mhlambiso started writing in primary school. “We are created differently; some are vocal, and some are not,” he says. “Being part of some that are not has made me opt for writing instead of constantly being vocal about issues and situations that some people go through.” University life sparked his passion for short stories, commencing with his submission of ‘Uthando Lukamama’ to the iCAN Project. 

Empowering through words: Mhlambiso's multifaceted literary mission

Mhlambiso explains he also uses writing to address unspoken societal issues, improve literacy levels, and preserve African languages. He captures contemporary stories, aligning with the iCAN Project's aim of decolonising curricula. He envisions fostering a more literate society through reading. “Dr Peet Van Aardt once said the project is a response from the centre for the ever-increasing need for decolonised curricula, steeped in the local cultural perspective of ubuntu, which is the iCAN Project, and A Journey Worth the Ride has exactly tapped into that, as it is a multilingual book,” he added.

He believes balancing academics and writing involves limited socialising and intensive reading. Creative writing masterclasses and workshops by the Academy for Multilingualism under the iCAN Project, and the UFS African Languages Press nourish his creativity. 

From dreams to community transformation: Mhlambiso's literary odyssey

Mhlambiso hails from an environment without libraries, and now he aims to transform his community through writing. His goal is to donate his works to schools, libraries, and book clubs, promoting literacy in native languages. His poetry and stories encourage collective change and emphasise youth action. 

His works relate strongly to the UFS’s Vision 130 and one of its component values, Innovation and Impact. His aims align with this vision through his engagements with local schools, libraries, and book clubs to confront their challenges. This includes addressing issues like the scarcity of books in native languages and contributing authored works to bridge this gap. 

As Mhlambiso's oft-repeated resounding call goes: "Let's embark on this journey; it is worth the ride!” 

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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