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UFS PhD student’s team wins Durban leg of prestigious Students Reinventing Cities competition

15 August 2023 | Story Anthony Mthembu | Photo Supplied

Ndumiso Mbuthuma, a PhD student at the University of the Free State (UFS), was part of a team that won the Durban leg of the Students Reinventing Cities competition. “It was a beautiful experience and an opportunity to not only be a student again but to contribute to the greater good,” Mbuthuma said.

The Students Reinventing Cities competition is coordinated by C40, a global network of nearly 100 mayors of the world’s leading cities who are united in action to confront the climate crisis.

The Umgeni Interchange Team, which consisted of Mbuthuma, who is a student in the UFS Centre for Development Support, three students from the University of Cape Town, and one from an institution in France, participated in the Durban leg of the competition, which began in April 2023.

After deliberations by C40 and city representatives, the team was informed on 13 July 2023 that they had been selected as the winners of the regional Durban competition.

The Students Reinventing Cities competition provides a platform for students and academics to work with cities around the world to formulate plans to combat climate change. This year the competition took place in 12 cities, including Barcelona, Durban, Rome, Melbourne, and Milan, among others. “The aim of the competition is to find ways in which we can begin to build cities that are climate change-friendly,” Mbuthuma said.

The winning presentation

The Umgeni Interchange Team was allocated four hectares of land by the eThekwini municipality to come up with a development idea. The team members, who specialise in various fields, had to rely on each other to create a winning project. Their proposal entailed the development of a mixed-use, commercial, retail, and affordable-housing block.

“We wanted to ensure affordable housing not just for the rich but even for those who aren’t,” Mbuthuma explained. His PhD, which focuses on floods and disasters, provided guidance on ensuring that the housing block was resistant to floods and other disasters. The proposal also suggested sustainable resource use, including the use of solar panels to generate energy in order to reduce the impact of loadshedding.

Even though a victory in the competition is a great feeling, Mbuthuma is more appreciative of the opportunity to have been active in the battle for a more sustainable future. “To hear that policymakers are interested in hearing what I have to say is a big deal to me.”

Future endeavours

Although there has been a concerted effort globally to combat climate change, Mbuthuma believes that in countries such as South Africa there hasn’t been adequate discourse around how development will take place in a future defined by climate change and the resulting disasters expected. As such, he is committed to working towards normalising these conversations.

News Archive

UFS study on cell development in top international science journal

2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.

Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za
18 September 2008

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