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07 December 2023 | Story Leonie Bolleurs | Photo CHARL DEVENISH
Dr Marié Herbst
Dr Marié Herbst received her PhD with specialisation in Design, titled The (S)Pace of Images: establishing a practice of the conscious abstraction of motion. She hopes that the techniques and processes explored in her research will spark creativity in the way other designers approach their work.

“My research has unveiled the exquisite patterns generated by motion in nature and everyday objects – patterns that often evade our awareness as we encounter motion in a fleeting moment. Abstraction plays a pivotal role in unveiling these exquisite yet largely unnoticed patterns that surround us.”

This is the perspective of Dr Marié Herbst, who graduated at the University of the Free State (UFS) in December, receiving her PhD with specialisation in Design, titled The (S)Pace of Images: establishing a practice of the conscious abstraction of motion.

Abstraction, a key component of building design

Dr Herbst says that the abstract art movement has had a profound influence on how designers think about design. “Highly regarded architects such as Le Corbusier and Zaha Hadid identify their practice of creating abstract paintings as the driving force behind their ground-breaking building designs. Abstraction is therefore a key component of building design, although the process of how it is applied has historically not received adequate attention. My research explores the way abstraction enables designers to include design information that is only possible through the process of abstraction. One such aspect is motion. Through the process of tracing and superimposing still images extracted from films, I can integrate them into a single picture that shows the progression of time,” she explains.

She hopes that the techniques and processes explored in her research will ignite creativity in how other designers approach their work. “The concepts and techniques outlined in my research are intended to prompt other designers to reconsider the procedures they employ when crafting spaces,” she states.

In the future, Dr Herbst says, she would like to further explore the ideas sparked by her research, such as determining how design would be affected by recording movement in a three-dimensional environment. “New technologies such as LiDAR make the recording of three-dimensional information much simpler, and it will increasingly become a part of our everyday lives. This is a potentially useful information stream that could be applied to create novel designs,” she says.

‘Practice-based’ versus ‘design-led’ research

Prof Jonathan Noble, Head of the Department of Architecture, says this is the very first PhD from the new creative research programme in architecture that was launched in 2018, where the student has completed a ‘design-led’ enquiry. 

He explains that the new creative programme differentiates between ‘practice-based’ research, closely tied to real-world architecture, where candidates analyse and study their previous work, and ‘design-led’ research, which is led by an entirely new creative exploration that encourage speculation and experimentation. According to him, the latter leads to a creative enquiry, and this body of new work is analysed and written about.

Following Prof Noble, postgraduate research in architecture in South Africa has traditionally centred around architectural theory, cultural history, urban studies, and conservation. Creative research methods, however, have not been as prominent. The Department of Architecture is addressing this by introducing new postgraduate research modes supported by innovative research degrees, marking a departure from the traditional approach in South Africa.

“We believe the programme will have a lasting and significant effect upon our professional degrees, injecting professional creativity and new thinking into the life of the department, and serving as an opportunity to look deeply into design and pedagogic practices. Over time, the programme will strengthen ties with the profession and address the closed mentalities of the so-called ‘academic ivory tower’.”

“In addition to providing emerging young scholars with opportunities, the programme facilitates the documentation of the unique qualities of South African practice and makes an important contribution to future research publication and teaching pedagogy at the UFS and beyond,” he says.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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