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07 December 2023 | Story Leonie Bolleurs | Photo CHARL DEVENISH
Dr Marié Herbst
Dr Marié Herbst received her PhD with specialisation in Design, titled The (S)Pace of Images: establishing a practice of the conscious abstraction of motion. She hopes that the techniques and processes explored in her research will spark creativity in the way other designers approach their work.

“My research has unveiled the exquisite patterns generated by motion in nature and everyday objects – patterns that often evade our awareness as we encounter motion in a fleeting moment. Abstraction plays a pivotal role in unveiling these exquisite yet largely unnoticed patterns that surround us.”

This is the perspective of Dr Marié Herbst, who graduated at the University of the Free State (UFS) in December, receiving her PhD with specialisation in Design, titled The (S)Pace of Images: establishing a practice of the conscious abstraction of motion.

Abstraction, a key component of building design

Dr Herbst says that the abstract art movement has had a profound influence on how designers think about design. “Highly regarded architects such as Le Corbusier and Zaha Hadid identify their practice of creating abstract paintings as the driving force behind their ground-breaking building designs. Abstraction is therefore a key component of building design, although the process of how it is applied has historically not received adequate attention. My research explores the way abstraction enables designers to include design information that is only possible through the process of abstraction. One such aspect is motion. Through the process of tracing and superimposing still images extracted from films, I can integrate them into a single picture that shows the progression of time,” she explains.

She hopes that the techniques and processes explored in her research will ignite creativity in how other designers approach their work. “The concepts and techniques outlined in my research are intended to prompt other designers to reconsider the procedures they employ when crafting spaces,” she states.

In the future, Dr Herbst says, she would like to further explore the ideas sparked by her research, such as determining how design would be affected by recording movement in a three-dimensional environment. “New technologies such as LiDAR make the recording of three-dimensional information much simpler, and it will increasingly become a part of our everyday lives. This is a potentially useful information stream that could be applied to create novel designs,” she says.

‘Practice-based’ versus ‘design-led’ research

Prof Jonathan Noble, Head of the Department of Architecture, says this is the very first PhD from the new creative research programme in architecture that was launched in 2018, where the student has completed a ‘design-led’ enquiry. 

He explains that the new creative programme differentiates between ‘practice-based’ research, closely tied to real-world architecture, where candidates analyse and study their previous work, and ‘design-led’ research, which is led by an entirely new creative exploration that encourage speculation and experimentation. According to him, the latter leads to a creative enquiry, and this body of new work is analysed and written about.

Following Prof Noble, postgraduate research in architecture in South Africa has traditionally centred around architectural theory, cultural history, urban studies, and conservation. Creative research methods, however, have not been as prominent. The Department of Architecture is addressing this by introducing new postgraduate research modes supported by innovative research degrees, marking a departure from the traditional approach in South Africa.

“We believe the programme will have a lasting and significant effect upon our professional degrees, injecting professional creativity and new thinking into the life of the department, and serving as an opportunity to look deeply into design and pedagogic practices. Over time, the programme will strengthen ties with the profession and address the closed mentalities of the so-called ‘academic ivory tower’.”

“In addition to providing emerging young scholars with opportunities, the programme facilitates the documentation of the unique qualities of South African practice and makes an important contribution to future research publication and teaching pedagogy at the UFS and beyond,” he says.

News Archive

Research contributes to improving quality of life for cancer patients
2016-11-21

Description: Inorganic Chemistry supervisors  Tags: Inorganic Chemistry supervisors

Inorganic Chemistry supervisors in the Radiopharmacy
Laboratory during the preparation of a typical complex
mixture to see how fast it reacts. Here are, from the left,
front: Dr Marietjie Schutte-Smith, Dr Alice Brink
(both scholars from the UFS Prestige
Scholar Programme), and Dr Truidie Venter (all three
are Thuthuka-funded researchers).
Back: Prof André Roodt and Dr Johan Venter.
Photo: Supplied

Imagine that you have been diagnosed with bone cancer and only have six months to live. You are in a wheelchair because the pain in your legs is so immense that you can’t walk anymore – similar to a mechanism eating your bones from the inside.

You are lucky though, since you could be injected with a drug to control the pain so effective that you will be able to get out of the wheelchair within a day-and-a-half and be able to walk again. Real-life incidents like these provide intense job satisfaction to Prof André Roodt, Head of Inorganic Chemistry at the University of the Free State (UFS). The research, which is conducted by the Inorganic Group at the UFS, contributes greatly to the availability of pain therapy that does not involve drugs, but improves the quality of life for cancer patients.

The research conducted by the Inorganic Group under the leadership of Prof Roodt, plays a major role in the clever design of model medicines to better detect and treat cancer.

The Department of Chemistry is one of approximately 10 institutions worldwide that conducts research on chemical mechanisms to identify and control cancer. “The fact that we are able to cooperate with the Departments of Nuclear Medicine and Medical Physics at the UFS, the Animal Research Centre, and other collaborators in South Africa and abroad, but especially the methodology we utilise to conduct research (studying the chemical manner in which drugs are absorbed in cancer as well as the time involved), enhances the possibility of making a contribution to cancer research,” says Prof Roodt.

Technique to detect cancer spots on bone
According to the professor, there are various ways of detecting cancer in the body. Cancer can, inter alia, be identified by analysing blood, X-rays (external) or through an internal technique where the patient is injected with a radioactive isotope.

Prof Roodt explains: “The doctor suspects that the patient has bone cancer and injects the person with a drug consisting of an isotope (only emits X-rays and does no damage to tissue) that is connected to a phosphonate (similar to those used for osteoporosis). Once the drug is injected, the isotope (Technetium-99m) moves to the spot on the bone where the cancer is located. The gamma rays in the isotope illuminate the area and the doctor can see exactly where treatment should be applied. The Technetium-99m has the same intensity gamma rays as normal X-rays and therefore operates the same as an internal X-ray supply.” With this technique, the doctor can see where the cancer spots are within a few hours.

The same technique can be used to identify inactive parts of the brain in Alzheimer patients, as well as areas of the heart where there is no blood supply or where the heart muscle is dead.

Therapeutic irradiation of cancer
For the treatment of pain connected with cancer, the isotope Rhenium-186 is injected. Similar to the manner in which the Technetium-99m phosphonate compound is ingested into the body, the Rhenium-186 phosphonate travels to the cancer spots. Patients thus receive therapeutic irradiation – a technique known as palliative therapy, which is excellent for treating pain. A dosage of this therapy usually lasts for about two months.

The therapy is, however, patient specific. The dosages should correspond with the occurrence and size of cancer spots in the patient’s body. First, the location of the cancer will be determined by means of a technetium scan. After that, the size of the area where the cancer occurs has to be determined. The dosage for addressing total pain distribution will be calculated according to these results.

Technique to detect cancer spots on soft tissue
Another technique to detect cancer as spots on bone or in soft tissue and organs throughout the body is by utilising a different type of irradiation, a so-called PET isotope. The Fluor-18 isotope is currently used widely, and in Pretoria a machine called a cyclotron was produced by Dr Gerdus Kemp, who is a former PhD graduate from the Inorganic Research Group. The F-18 is then hidden within a glucose molecule and a patient will be injected with the drug after being tranquillised and after the metabolism has been lowered considerably. The glucose, which is the ‘food' that cancer needs to grow, will then travel directly to the cancer area and the specific area where the cancer is located will thus be traced and ‘illuminated’ by the Fluor-18, which emits its own 'X-rays'.

In the late 80s, Prof Roodt did his own postdoctoral study on this research in the US. He started collaborating with the Department of Nuclear Medicine at the UFS in the early 90s, when he initiated testing for this research.

Through their research of more than 15 years, the Inorganic Group in the Department of Chemistry has made a major contribution to cancer research. Research on mechanisms for the detection of cancer, by designing new clever chemical agents, and the chemical ways in which these agents are taken up in the body, especially contributes to the development in terms of cancer therapy and imaging, and has been used by a number of hospitals in South Africa.

The future holds great promise
Prof Roodt and his team are already working on a bilateral study between the UFS and Kenya. It involves the linking of radio isotopes, as mentioned above, to known natural products (such as rooibos tea), which possess anti-cancer qualities.

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