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13 December 2023 | Story André Damons | Photo Charl Devenish
Dr Shezree Tiel
Top student: Dr Shezree Tiel graduated top of her class and summa cum laude during the Faculty of Health Sciences graduation ceremony on Friday.

As she achieved the goals she had set for herself, Dr Shezree Tiel, one of the latest graduates from the University of the Free State (UFS) Faculty of Health Sciences (FoHS), developed the courage to not only define her goals, but aim for even more. This is the reason she graduated not only summa cum laude, but as the top student in her year group.

Dr Tiel was one of 459 students who graduated on Friday (8 December 2023) during the FoHS’s December graduation ceremony. She graduated with a MBChB degree and is one of eight students to do so summa cum laude. During her five years of studies to become a medical doctor, she was the top student in each of her year groups.  

“I feel very excited and still in disbelief, because it has been my dream since first year to graduate cum laude, but there were moments I felt I may have to accept that it may not be possible. So, I am very delighted that despite all the challenges I faced, my dream was realised,” she said.

According to her, she decided to study at UFS as it is the only university in South Africa that offered a five-year medical degree.

Building healthier and happier communities

Talking about how she achieved this, Dr Tiel, who will be doing her community service year in her home province of Mpumalanga, said what was consistent throughout her years of study, was the need to avoid a uniform approach to studying. Instead, she continued, she embraced different ways to learn.

Said Dr Tiel: “I embraced different ways to acquire knowledge and used these to identify a method of study that would be best suited for each module, chapter and sometimes each day. Everyday courage, resilience, patience, and perseverance played a vital role in accomplishing all my achievements. In spite of all of this, I will always attribute my achievements to my trust in Christ.”

Her desire to make the best possible use of every opportunity she gets to gain knowledge and the hope to use that knowledge to be useful to people and communities, motivated her on her journey to become a doctor. She decided to study medicine because she aspired to work with people in the pursuit of building healthier and happier communities. She believed that medicine would provide a great foundation and platform to accomplish this.

Though she is yet to decide in which field she would like to specialise one day, she believes it would be in internal medicine because it has always been one of her favourite rotations. “I do hope whichever one I go into will provide me with an opportunity to teach because that is one of the things I delight in.”

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Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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