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13 December 2023 | Story André Damons | Photo Charl Devenish
Dr Shezree Tiel
Top student: Dr Shezree Tiel graduated top of her class and summa cum laude during the Faculty of Health Sciences graduation ceremony on Friday.

As she achieved the goals she had set for herself, Dr Shezree Tiel, one of the latest graduates from the University of the Free State (UFS) Faculty of Health Sciences (FoHS), developed the courage to not only define her goals, but aim for even more. This is the reason she graduated not only summa cum laude, but as the top student in her year group.

Dr Tiel was one of 459 students who graduated on Friday (8 December 2023) during the FoHS’s December graduation ceremony. She graduated with a MBChB degree and is one of eight students to do so summa cum laude. During her five years of studies to become a medical doctor, she was the top student in each of her year groups.  

“I feel very excited and still in disbelief, because it has been my dream since first year to graduate cum laude, but there were moments I felt I may have to accept that it may not be possible. So, I am very delighted that despite all the challenges I faced, my dream was realised,” she said.

According to her, she decided to study at UFS as it is the only university in South Africa that offered a five-year medical degree.

Building healthier and happier communities

Talking about how she achieved this, Dr Tiel, who will be doing her community service year in her home province of Mpumalanga, said what was consistent throughout her years of study, was the need to avoid a uniform approach to studying. Instead, she continued, she embraced different ways to learn.

Said Dr Tiel: “I embraced different ways to acquire knowledge and used these to identify a method of study that would be best suited for each module, chapter and sometimes each day. Everyday courage, resilience, patience, and perseverance played a vital role in accomplishing all my achievements. In spite of all of this, I will always attribute my achievements to my trust in Christ.”

Her desire to make the best possible use of every opportunity she gets to gain knowledge and the hope to use that knowledge to be useful to people and communities, motivated her on her journey to become a doctor. She decided to study medicine because she aspired to work with people in the pursuit of building healthier and happier communities. She believed that medicine would provide a great foundation and platform to accomplish this.

Though she is yet to decide in which field she would like to specialise one day, she believes it would be in internal medicine because it has always been one of her favourite rotations. “I do hope whichever one I go into will provide me with an opportunity to teach because that is one of the things I delight in.”

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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