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07 December 2023 | Story Leonie Bolleurs | Photo Charl Devenish
Dr Michelle Goliath
Dr Michelle Goliath received her PhD, providing significantly useful insights into artisanal mining. She says it is the prospect of contributing to positive change and advancing understanding in the field that has been the most exciting and fulfilling aspect of completing this research.

Dr Michelle Goliath completed her PhD in the Department of Urban and Regional Planning at the University of the Free State (UFS) and received her qualification during the December graduations. 

The PhD, which she began in 2018 under supervision of Prof Malene Campbell, is titled Urban Pacification Strategies and Solutions: Towards a Contested Space Theory of Artisanal Mining.

The focus of her thesis was on finding strategies to address informal mining in urban areas. “It considers the formalisation of informal miners, adapted land use management, risk management solutions, and action research to solve complex problems. In addition, it also looks at the social, economic, and environmental dimensions of the challenge and proposes a unique practical methodology on how to solve similar complex problems and challenges that urban planners and policy makers face daily,” explains Dr Goliath. 

A foundation for informed decision making

She is of the opinion that her research provides a foundation for informed decision making by town planners who seek to proactively address and mitigate challenges around artisanal mining.

Dr Goliath’s thesis introduces innovative strategies for managing land use specifically designed for the challenges of artisanal mining. She believes that recognising the importance of flexible and innovative land-use policies demonstrates a deep understanding of the spatial aspects involved in effectively accommodating and regulating artisanal mining activities. As reported by Dr Goliath, this customised approach ensures that the rules fit the unique characteristics of artisanal mining, promoting sustainable urban development.

Moreover, by integrating action research methodologies into the thesis, a dynamic and collaborative element is introduced into the decision-making process. She says that engaging in practical, on-the-ground research in collaboration with practitioners – in this instance a community of women artisanal miners in Kimberley – advocates for evidence-based decision making in urban planning. “This approach not only enriches the theoretical foundation of the thesis, but also ensures that the proposed solutions are rooted in the practical realities of the South African context,” she states.

Furthermore, the thesis offers both theoretical insights and practical policy recommendations, ensuring that its research findings extend beyond academia. These insights are directly applicable to the challenges confronted by town planners in South Africa and policy planners in other SADEC countries who are still navigating the policy process for similar challenges. “The incorporation of global trends in artisanal mining allows for a comparative approach, enhancing the relevance and transferability of the recommendations both locally and internationally,” remarks Dr Goliath.

The impact of empowerment

She says it is fulfilling to witness the transformative impact of empowerment. “Engaging with and supporting women in the artisanal mining sector has not only enhanced their economic opportunities but has also contributed to broader social and community development. It is the empowerment of these women, their resilience, and the tangible positive shifts in their lives that stand out as the most rewarding and impactful outcomes of my work in Kimberley.”

Besides the opportunity to help this group of women, she was also excited about the chance to contribute new knowledge and insights to the field. “The process of delving into unexplored aspects of artisanal mining in Kimberley, conducting thorough investigations, and analysing longitudinal data has been intellectually stimulating,” she states.

“The prospect of offering novel perspectives, innovative solutions, and evidence-based recommendations through my research is particularly thrilling. Witnessing the potential for this work to make a meaningful impact on policies, practices, and the lives of individuals involved in artisanal mining adds a sense of purpose and excitement to the research journey,” concludes Dr Goliath.

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Cardiology Unit involved in evaluation of drug for rare genetic disease
2013-01-04

Front from the left, are: Marinda Karsten (study coordinator and registered nurse),
Laumarie de Wet (clinical technologist), Charmaine Krahenbuhl (study coordinator and radiographer),
Lorinda de Meyer (administrator), Andonia Page (study coordinator and enrolled nurse);
back Dr Gideon Visagie (sub investigator), Dr Derick Aucamp (sub investigagtor),
Prof. Hennie Theron, (principal investigator) and Dr Wilhelm Herbst (sub investigator).
Photo: Supplied
09 January 2013


The Cardiology Research Unit at the University of the Free State (UFS) contributed largely to the evaluation of the drug Juxtapid (lomitapide), which was developed by the Aegerion pharmaceutical company and approved by the FDA (Federal Drug Administration). Together with countries such as die USA, Canada and Italy, the UFS’ Unit recruited and evaluated the most patients (5 of 29) for the study since 2008.  

The drug was evaluated in persons with so-called familial homozygous hypercholesterolemia (HoFH).  

Following its approval by the FDA, Juxtapid is now a new treatment option for patients suffering from HoFH. The drug operates in a unique way which brings about dramatic improvements in cholesterol counts.  

According to Prof. Hennie Theron, Associate Professor in the Department of Cardiology at the UFS and Head of the Cardiology Contract Research Unit, HoFH is a serious, rare genetic disease which affects the function of the receptor responsible for the removal of low-density lipoprotein cholesterol (LDL-C) (“bad” cholesterol) from the body. Damage to the LDL receptor function leads to extremely high levels of blood cholesterol. HoFH patients often develop premature and progressive atherosclerosis, which is a narrowing or blockage of the arteries.  

“HoFH is a genetically transmitted disease and the most severe form of hypercholesterolemia. Patients often need a coronary artery bypass or/and aortic valve replacement before the age of 20. Mortality is extremely high and death often occurs before the third decade of life. Existing conventional cholesterol-lowering medication is unsuccessful in achieving normal target cholesterol values in this group of patients.  

“The only modality for treatment is plasmapheresis (similar to dialysis in patients with renal failure). Even with this type of therapy the results are relatively unsatisfactory because it is very expensive and the plasmapheresis has to be performed on a regular basis.  

“The drug Juxtapid, as currently evaluated, has led to a dramatic reduction in cholesterol values and normal values were achieved in several people. No existing drug is nearly as effective.  

“The drug represents a breakthrough in the treatment of familial homozygous hypercholesterolemia. The fact that it has been approved by the FDA, gives further impetus to the findings,” says Prof. Theron.  

In future further evaluation will be performed in other forms of hypocholesterolemia.  

According to Prof. Theron, the findings of the study, as well as the recent successful FDA evaluation, once again confirms the fact that the UFS’ Cardiology Contract Research Unit is doing outstanding work.  

Since its inception in 1992, the Unit has already been involved in more than 60 multi-centre, international phase 2 and 3 drug studies. Several of these studies, including the abovementioned study, really affected the way in which cardiology functions.  

The UFS’ Cardiology Contract Research Unit is being recognised nationally and internationally for its high quality of work and is constantly approached for their involvement in new studies.  

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