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28 February 2023 | Story Edzani Nephalela | Photo Edzani Nephalela
Dr Luyanda Marhaya
Dr Luyanda Marhaya, Director of Academic Planning and Quality Assurance at the UFS.

Dr Luyanda Marhaya, Director of Academic Planning and Quality Assurance at the University of the Free State (UFS), has been selected by the Department of Higher Education and Training (DHET) to join the Foundation Provision Reference Group (FPRG). His primary role in this position is to assist the Department in assessing applications for foundation programmes submitted by universities, ensuring compliance with the current Foundation Provision Guidelines. 

As the author of the book Does Extended Programme Provision Work in South Africa?, Dr Marhaya is a recognised expert in the field. 

The Department of Communication and Marketing (DCM) at the UFS recently interviewed Dr Marhaya to understand his responsibilities better:

Can you tell us more about your appointment as a member of the FPRG?

Over and above the supportive role, one of the major issues I will be involved in will be to provide input into the revision and finalisation of the Extended Curriculum Programme Policy Framework for the higher sector in South Africa.

What kind of projects or initiatives do you see being a priority?

One of the significant ongoing projects will be evaluating applications for foundation programmes of the different universities in South Africa, so one will have to allocate time, as many universities currently offer these programmes.

What do you hope to bring to the table as a group member?

Interestingly, I started as an academic about 15 years ago in the foundation programmes. I spent a good five years of my teaching at a university level dealing with students who gained entry through foundation programmes. I completely understand their purpose, intentions, and significance, especially concerning student access and success. 

How will the Foundation Provision Reference Group benefit students and the education system?

Student access is a serious issue in South Africa, especially regarding the preparedness of many university students. So, I believe if we develop guidelines that can assist universities in coordinating these programmes in a well-structured manner, there could be many benefits.

What challenges do you anticipate facing in this role, and how do you plan to address them?

I think the major issue will be time constraints. My role is very demanding, and I am already involved in several other external committees, such as the Council on Higher Education, so I think my time management has to be very good.

How do you plan to work with other group members to achieve the group’s goals?

I believe in lifelong learning. I will certainly contribute, but the value of these interactions comes from learning from others.

Can you discuss any past experiences that have prepared you for this role?

I also wrote a book, titled Does Extended Programme Provision Work in South Africa?, in which I explored all the intricacies around these programmes. As Director: Academic Planning at the UFS, I also oversee the quality and provision of foundation programmes, so you could say I bring some expertise.

What are your long-term goals for the foundation programmes, and your role as a reference group member?

I foresee this as a long-term service that will benefit the country as a whole, so I suppose the Department will keep up so that we can provide capacity development to all universities that offer foundation programmes.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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